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Increase of NADPH-diaphorase Expression in Hypothalamus of Stat4 Knockout Mice
MeeSookHong, JeongYoonSong, DongHwanYun, Jeong-JeCho, Joo-HoChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 1 337-341 (5 pages)
Signal transducer and activator of transcription 4 (STAT4), a STAT family member, mediates interleukin 12 (IL12) signal transduction. IL12 is known to be related to calorie-restricted status. In the central nervous system, IL12 also enhances the production of nitric oxide (NO), which regulates food intake. In this study, the expression of neuronal NO synthase (Nos1), which is also related to food intake, was investigated in the hypothalamic areas of Stat4 knockout (KO) mice using nicotinamide... -
Alpha-Calcitonin Gene-Related Peptide-Null Mice Shows Normal Responses to Various Noxious Stimuli
JonghoLee, RonaldB.Emeson 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.6 5 323-328 (6 pages)
Despite the wealth of data concerning the roles of α-CGRP in nociceptive behaviors, α-CGRP-null mice showed no obvious phenotypic differences in nociceptive behaviors from wild type. The present studies specifically demonstrate that α-CGRP null mice showed no CGRP immunoreactivity from the spinal cord, implying that CGRPs in the mice spinal cord are mainly a-isoforms. However, the nociceptive behaviors of the null mice are not significantly different from the wild type mice in thermal...
