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Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
KyungEunKim, HwajinKim, RokWonHeo, HyunJooShin, Chin-okYi, DongHoonLee, HyunJoonKim, SangSooKang, GyeongJaeCho, WanSungChoi, GuSeobRoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 8 451-460 (10 pages)
Sirtuin 1 (SIRT1) is a mammalian NAD＋-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflam-mation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation con-tributes to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO)... -
The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice
Yun-BeomSim, Soo-HyunPark, Sung-SuKim, Chea-HaKim, Su-JinKim, Su-MinLim, Jun-SubJung, Ohk-HyunRyu, Moon-GiChoi, Hong-WonSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 5 41-46 (6 pages)
in D-glucose-fed model. In addition, α-methylhistamine, but not carcinine, slightly but sig-nificantly enhanced the blood glucose level D-glucose-fed model. Finally, i.t. pretreatment with JNJ 7777120, but not VUF 8430, slightly but significantly increased the blood glucose level. Although histamine receptors themselves located at the spinal cord do not exert any effect on the regulation of the blood glucose level, our results suggest that the activation of spinal histamine H2 receptors and the... -
Induction of Heat Shock Proteins and Antioxidant Enzymes in 2,3,7,8-TCDD-Induced Hepatotoxicity in Rats
Hyun-SookKim, So-YoungPark, Ki-YeolYoo, SeungKwanLee, Woon-WonJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 14 469-476 (8 pages)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) is an environmental toxicant with a polyhalogenated aromatic hydrocarbon structure and is one of the most toxic man-made chemicals. Exposure to 2,3,7,8-TCDD induces reproductive toxicity, immunotoxicity, and hepatotoxicity. In this study, we evaluated how 2,3,7,8-TCDD-induced hepatotoxicity affect the expression of heat shock proteins and antioxidant enzymes using the real-time polymerase chain reaction (PCR) in rat. 2,3,7,8-TCDD increased heat... -
Disappearance of Hypoxic Pulmonary Vasoconstriction and O2-Sen-sitive Nonselective Cationic Current in Arterial Myocytes of Rats Under Ambient Hypoxia
HaeYoungYoo, SungJoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 13 463-468 (6 pages)
Acute hypoxia induces contraction of pulmonary artery (PA) to protect ventilation/perfusion mismatch in lungs. As for the cellular mechanism of hypoxic pulmonary vasoconstriction (HPV), hypoxic inhibition of voltage-gated K+ channel (Kv) in PA smooth muscle cell (PASMC) has been suggested. In addition, our recent study showed that thromboxane A2 (TXA2) and hypoxia-activated nonselective cation channel (INSC) is also essential for HPV. However, it is not well understood whether HPV is maintained... -
Curcumin Attenuates Radiation-Induced Inflammation and Fibrosis in Rat Lungs
YuJiCho, ChinOkYi, ByeongTakJeon, YiYeongJeong, GiMunKang, JungEunLee, GuSeobRoh, JongDeogLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 3 267-274 (8 pages)
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage... -
Dexamethasone Induces FcgRIIb Expression in RBL-2H3 Cells
PrashantaSilwal, Mi-NamLee, Choong-JaeLee, Jang-HeeHong, UkNamgung, Zee-WonLee, JinhyunKim, KyuLim, GiRyangKweon, JongILPark, SeungKielPar 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 4 393-398 (6 pages)
Mast cells are involved in allergic responses, protection against pathogens and autoimmune diseases. Dexamethasone (Dex) and other glucocorticoids suppress FcՅRI-mediated release of inflammatory mediators from mast cells. The inhibition mechanisms were mainly investigated on the downstream signaling of Fc receptor activations. Here, we addressed the effects of Dex on Fc receptor expressions in rat mast cell line RBL-2H3. We measured mRNA levels of Fc receptors by real-time PCR. As... -
Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines
InseokJang, ByeongTakJeon, EunAeJeong, Eun-JinKim, DawonKang, JongSilLee, BaekGeunJeong, JinHyunKim6, BongHoiChoi6, JungEunLee, JongWooKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.3 2 159-165 (7 pages)
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the precise mechanisms underlying their migration and invasion are not yet known. Here, we address the involvement in NSCLC of the p21-associated kinase1 (Pak1)/LIM kinase1 (LIMK1)/cofilin pathway, which recently has been reported to play a critical role in tumor migration and invasion.... -
하구폐색저감을 위한 도류제 제원에 관한 연구
최창진, 추연문, 김성범, 지홍기 한국습지학회 한국습지학회지 13 Pages
한국습지학회 한국습지학회지 2014, Vol.16 No.1 14 139-151 (13 pages)
본 연구에서는 완경사 하천에 유입하는 지류 하구부 하도폐색현상을 규명하기 위하여 본류하도로 유입하는 합류각이 30°, 45°, 60°, 75° 형태의 가상하도 합류부의 구조를 설정한 후, 수제의 길이가 본류하도 하폭의 4%, 6%, 8%, 10%에 해당하는 도류제에 대해서 각각의 수리학적 특성을 SMS의 RMA-2와 SED2D 모형을 이용하여 수치해석을 실시하였다. 수치해석 결 과에서 설정된 적정 도류제를 낙동강 본류에 유입하는 합류각이 큰 감천 합류부와 합류각이 작은 위천 합류부에 적용하 여 유속, 수위, 하상변동 등 수리학적 특성... -
댐 건설이 하류하천 하상에 미치는 영향 분석
추태호, 채수권 한국습지학회 한국습지학회지 9 Pages
한국습지학회 한국습지학회지 2012, Vol.14 No.4 24 715-723 (9 pages)
영향을 1차원 및 2차원 모형을 사용하여 분석하였다. 유량-유사량은 댐의 유지유량과 지류에서 들어오는 유사량의 유역면적비에 의 해서 산정된 값을 입력 자료로 활용 하였다. 1차원 모형은 HEC-6 모형을 사용하였고 2차원 모형은 SMS의 SED2D 모형을 사용하여 분석하였다. HEC-6 모형은 10년 전 하상에 데이터를 넣어 현재 하상과 가장 일치하는 공식인 Yang공식을 선정하여 현재 하상으로부터 20년 후를 모의하였다. SED-2D 모형은 현재 하상을 기준으로 20년 후를 모의하였고 두 모형 분석 결과 회룡포 구간에서는 동일한 양상이... -
저수지내 수리구조물에 의한 퇴사량 제어 효과
조홍제, 강호선, Cho. Hong Je, Kang. Ho Seon 한국수자원학회 韓國水資源學會論文集 11 Pages
한국수자원학회 韓國水資源學會論文集 2013, Vol.46 No.12 1157-1167 (11 pages)
본 연구에서는 사연댐 퇴사량 실측자료를 이용하여 SED-2D 모형의 적용성을 검토하고, 야산을 이용하여 취수탑이 있는 댐 주변의 저수지 입구에 도수제와 유사한 소규모 수리구조물을 설치할 때 퇴사의 유입억제와 취수에 필요한 수심확보 가능성을 검토하였다. 이를 위해 야산이 있는 현상태를 기준으로, 야산을 철거할 때와 추가로 구조물을 더 높게 설치할때 등을 고려하여 수리학적 효과와 그에 따른 퇴사량 감소 등을 모의 하였다. 그 결과 장기유출에 의한 50년 후 저수지내 퇴사 깊이는 평균 2.335~5.847m 발생하는 것으로...
