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Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation
GyoungWanLee, JaeHyoKim, MinSunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 8 423-428 (6 pages)
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer’s collateral commissural fibers were... -
Lamotrigine, an antiepileptic drug, inhibits 5-HT3 receptor currents in NCB-20 neuroblastoma cells
KiJungKim, SeungHyunJeun, Ki-WugSung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 4 169-177 (9 pages)
Hill coefficient of 1.2±0.1. These peak amplitude decreases were accompanied by the rise slope reduction. In addition, 5-HT3-mediated currents evoked by 1 mM dopamine, a partial 5-HT3 receptor agonist, were inhibited by lamotrigine co-application. The EC50 of 5-HT for 5-HT3 receptor currents were shifted to the right by co-application of lamotrigine without a significant change of maximal effect. Currents activated by 5-HT and lamotrigine co-application in the presence of 1 min pretreatment of... -
Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week
JiWoongAhn, ShinWookKang, SeungCheolAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.4 11 383-388 (6 pages)
K+ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) mice of the same age (postnatal day (P) 0 −P6) were used as controls. Similar slow rising K+ currents were observed in both genotypes, but their biophysical and pharmacological properties were quite different. The values of Vhalf for activation were... -
Open Channel Block of Kv3.1 Currents by Genistein, a Tyrosine Kinase Inhibitor
BokHeeChoi, JiHyunPark, SangJuneHahn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.2 3 71-78 (8 pages)
The goal of this study was to analyze the effects of genistein, a widely used tyrosine kinase inhibitor, on cloned Shaw-type K currents, Kv3.1 which were stably expressed in Chinese hamster ovary (CHO) cells, using the whole-cell configuration of patch-clamp techniques. In whole-cell recordings, genistein at external concentrations from 10 to 100μM accelerated the rate of inactivation of Kv3.1 currents, thereby concentration-dependently reducing the current at the end of depolarizing... -
Direct Block of Cloned K+ Channels, Kv1.5 and Kv1.3, by Cyclosporin A, Independent of Calcineurin Inhibition
BokHeeChoi, SangJuneHahn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 7 353-362 (10 pages)
The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at 50 mV in a reversible concentration- dependent manner with an apparent IC50 of 1.0μM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA.... -
The Alteration of Ca2+-activated K+ Channels in Coronary Arterial Smooth Muscle Cells Isolated from Isoproterenol-induced Cardiac Hypertrophy in Rabbit
NariKim, JinHan, EuiyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.2 5 147-156 (10 pages)
patch clamp technique. The main findings of the present study are as follows: (1) the unitary current amplitudes and the slope conductance of coronary KCa channels were decreased without changes of the channel kinetics in isoproterenol-induced cardiac hypertrophy; (2) the sensitivity of coronary KCa channels to the changes of intracellular concentration of Ca2 was reduced in isoproterenol-induced cardiac hypertrophy. From above results, we suggest for the first time that the alteration of... -
Two Types of Voltage-dependent Outward Potassium Currents in Smooth Muscle Cells of Rabbit Basilar Atery
TongMookKang, InsukSo, DaeYongUhm, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 15 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 7 169-183 (15 pages)
We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current (IK(V)) and 'A-like' transient outward K current (Ito) with patch-clamp technique in single smooth muscle cells (SMCs) isolated from rabbit basilar artery, and investigated the characteristics of them. The time-courses of activation were well fitted by exponential function raised to second power (n2) in IK(v) and fourth power (n4) in Ito. The activation, inactivation and... -
남녀 음성신호의 포만트 형태 비교를 통한 음주여부판단 관한 연구
이원희(Won-Hee Lee), 배명진(Myung-Jin Bae) 인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 9 Pages
인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 2018, 제 8권 제 9호 85 863-871 (9 pages)
본 논문에서는 남녀 음성 분석을 이용하여 음주 전후의 음성특징을 비교하면서 음주여부를 판단할 수 있는 파라미터를 연구하였다. 기존에 제안된 방법은 변화하는 있는 운율, 발성상태 같은 특징을 정확하게 추출하고 분류하여 음주판단여부을 진행하였다. 또 다른 방법으로 음주 전후 포만트의 기울기 값을 이용하여 음주 여부를 판단할 수 있다. 포만트 기울기를 통한 음주판단방법은 대표적은 주파수 스펙트럼 형태를 근본으로한 음주판단방법이며 음주를 하기되면 음성신호의 주파수 스펙트럼 형태가 비음화 현상으로 인해 고주파... -
체계적 문헌고찰을 통한 폐경기 여성의 고혈압 관리를 위한 운동 중재 비교 연구
문혜경, 이은영 인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 10 Pages
인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 2018, 제 8권 제 2호 82 839-848 (10 pages)
본 연구의 목적은 폐경기 여성의 고혈압 조절을 위한 용량 반응 운동 프로그램과 효과에 대해 평 가하고 체계적으로 분석하는 것이다. 검색 데이터베이스는 CINAHL, Pubmed, Cochrane Library, and Ovid-Medline를 이용하였으며, 검색어로는 “postmenopausal women”, “hypertension”, “dose response”, “exercise”를 이용하여 검색된 총 15편의 논문을 대상으로 분석을 실시하였다. 분석의 대상 은 2001년 1월부터 2017년 5월까지 폐경기 여성의 고혈압과 관련된 운동 프로그램으로 국외에서 출판 된 연구이다. 포함 된 모든... -
승강기 EDLC 비상전원 전력변환장치 제어 알고리즘 연구
이상민, 김일송, 김남 인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 10 Pages
인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 2017, 제 7권 제 6호 66 709-718 (10 pages)
최근 정전시에 엘리베이터에 탑승한 승객들을 안전하게 대피시킬 수 있는 비상전원장치가 법제화 됨에 따라서 이 시스템에 대한 관심이 증대되고 있다. 본 연구에서는 대용량 커패시터에 필요 전력을 직류로 저장한 상태에서 정전시 교류 380V를 발생시켜 엘리베이터가 일정시간 동안 동작할 수 있는 비상전원장치(PCS : Power Conditioning System) 설계에 대한 내용을 다룬다. PCS에 사용되는 전력 변환장치의 제어시스템은 원하는 응답 특성을 얻기 위한 전류제어기로 구성되어져 있다. 전류제어기 의 설계 방법에는 일반적으로 빠른...
