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Changes of colonic endocrine cells in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis
Young Doo Back , Hyeung Sik Lee , In Kwon Chung , Woo Hyun Cheon , Sae Kwang Ku 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 9 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2011, 제 51권 제 2호 1 83-91 (9 pages)
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GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition
HwaOkLee, YuJeongByun, Kyung-OkCho, SeongYunKim, Seong-BeomLee, Ho-ShikKim, Oh-JooKwon, Seong-WhanJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 5 149-156 (8 pages)
Golgi SNAP receptor complex 1 (GS28) has been implicated in vesicular transport between intra-Golgi networks and between endoplasmic reticulum (ER) and Golgi. Additional role(s) of GS28 within cells have not been well characterized. We observed decreased expression of GS28 in rat ischemic hippocampus. In this study, we examined the role of GS28 and its molecular mechanisms in neuronal (SK-N-SH) cell death induced by hydrogen peroxide (H2O2). GS28 siRNA-transfected cells treated with H2O2 showed... -
YKP1447, A Novel Potential Atypical Antipsychotic Agent
SeonMinDong, YongGilKim, JoonHeo, MiKyungJi, JeongWooCho, ByongSungKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 1 71-78 (8 pages)
(S)-Carbamic acid 2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-1-phenyl-ethyl ester hydrochloride (YKP1447) is a novel "atypical" antipsychotic drug which selectively binds to serotonin (5-HT2A, Ki=0.61 nM, 5-HT2C, Ki=20.7 nM) and dopamine (D2, Ki=45.9 nM, D3, Ki=42.1 nM) receptors with over 10∼100-fold selectivity over the various receptors which exist in the brain. In the behavioral studies using mice, YKP1447 antagonized the apomorphine-induced cage climbing (ED50=0.93 mg/kg) and DOI-induced head... -
Assessment of Flavin-containing Monooxygenase (FMO) Activity by Determining Urinary Ratio of Theobromine and Caffeine in a Korean Population after Drinking a Cup of Coffee
Woon-GyeChung, , Ju-HeeKang, Hyung-KeunRoh, Kyung-HoonLee, Chang-ShinPark, Young-NamCha, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 11 207-213 (7 pages)
To examine individual variation in drug metabolism catalyzed by flavin-containing monooxygenase (FMO), 179 Korean volunteers' urinary molar concentration ratio of theobromine (TB) and caffeine (CA) was determined. Their urine was collected for 1 hr (between 4 and 5 hrs) after they drank a cup of coffee containing 115 mg CA and analyzed by an HPLC system. The lowest TB/CA ratio obtained was 0.40, the highest ratio was 15.17 (38-fold difference), and the median ratio for all subjects was 1.87.... -
Chlorpromazine의 유전적 안전성에 관한 연구
김한규, 손윤희, 이광헌, 윤태호, 남경수 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 3호 14 629-637 (9 pages)
연구목적： 항 정신성약물로 사용빈도가 높은 chlorpromazine을 사용하여 이 약물의 돌연변이원성과 유전독성을 알 아보았다. 방 법： Bacillus subtilis을 사용한 DNA손상성검토(rec assay), Salmonella typhimurium을 이용한 돌연변이원 성실험(Ames test 및 SOS umu test) 그리고 생쥐에 chlorpromazine를 직접 주입하여 대사 후에 돌연변이 원성을 확인하는 host-mediated assay법을 각각 사용하였다. 결 과： Rec assay에서 chlorpromazine은 Bacillus subtilis의 DNA에는 별다른 영향을 미치지 않았으며, Salmonella typhomurium TA... -
새로운 Platinum (II) Complex [Pt (II)(trans-d-dach)(DPPE)] (NO3)2의 항암효과 및 신독성에 관한 연구
정지창(Jee-Chang Jung), 이문호(Moon-Ho Lee), 장성구(Sung-Goo Chang), 노영수(Young-Soo Rho) 대한약리학회 대한약리학잡지 12 Pages
대한약리학회 대한약리학잡지 1995, 제 31권 제 1호 11 103-114 (12 pages)
일부 malignant tumor에 Pt-complex의 일상 응용 과정에서 신장독성등의 심한 부작용이 문제점으로 지적되고 있다. 이 연구에서는 기존의 cisplatin보다 항암효과는 우수하면서, 부작용을 감소시킨 새로운 Pt-complex의 개발에 역점을 두었다. 본 연구에서 합성한 Pt(Ⅱ) complex는 carrier ligand로서 1,2-diaminocyclohexane(dach)을 사용하였고, leaving group으로는 diophosphine류인 1,2-bisdiphenylphosphinoethane(DPPE)을 도입하였으며, 물에 대한 용해도를 높이기 위해 dinitrate로 만들었다. 새로이 합성한... -
Neuroendocrine Control of Gonadotropin Secretion during the Menstrual Cycle
Ryu Kyung-Za 대한약리학회 대한약리학잡지 20 Pages
대한약리학회 대한약리학잡지 1987, 제 23권 제 2호 1 57-76 (20 pages)
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Effect of Salicylic Acid Formulations on Induced Plant Defense against Cassava Anthracnose Disease
Rungthip Sangpueak, Piyaporn Phansak, Kanjana Thumanu, Supatcharee Siriwong, Sopone Wongkaew, Natthiya Buensanteai 한국식물병리학회 The Plant Pathology Journal 9 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 4호 5 356-364 (9 pages)
This study was to investigate defense mechanisms on cassava induced by salicylic acid formulation (SA) against anthracnose disease. Our results indicated that the SA could reduce anthracnose severity in cassava plants up to 33.3% under the greenhouse condition. The β-1,3-glucanase and chitinase enzyme activities were significantly increased at 24 hours after inocula- tion (HAI) and decrease at 48 HAI after Colletotrichum gloeosporioides challenge inoculation, respectively, for cassava treated... -
Identification of Plant Viruses Infecting Pear Using RNA Sequencing
Nam-Yeon Kim, Hyo-Jeong Lee, Hong-Sup Kim, Su-Heon Lee, Jae-Sun Moon, Rae-Dong Jeong 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 3호 5 258-267 (10 pages)
to ex- amine and provide a comprehensive overview of virus populations infecting a major pear cultivar (‘Singo’) in Korea. From June 2017 to October 2019, leaf samples (n = 110) of pear trees from 35 orchards in five major pear-producing regions were collected and subjected to RNA sequencing. Most virus-associated contigs matched the sequences of known viruses, including apple stem grooving virus (ASGV) and apple stem pit- ting virus (ASPV). However, some contigs matched the sequences of apple... -
Research Notes : The RpoS Sigma Factor Negatively Regulates Production of IAA and Siderophore in a Biocontrol Rhizobacterium, Pseudomonas chlororaphis O6
한국식물병리학회 The Plant Pathology Journal 7 Pages
한국식물병리학회 The Plant Pathology Journal 2013, 29권 3호 11 323-329 (7 pages)
The stationary-phase sigma factor, RpoS, influences the expression of factors important in survival of Pseudomonas chlororaphis O6 in the rhizosphere. A partial proteomic profile of a rpoS mutant in P. chlororaphis O6 was conducted to identify proteins under RpoS regulation. Five of 14 differentially regulated proteins had unknown roles. Changes in levels of proteins in P. chlororaphis O6 rpoS mutant were associated with iron metabolism, and protection against oxidative stress. The P....
