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전체 선택해제
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본문검색 결과만 보기
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Cyclophilin A as a New Therapeutic Target for Hepatitis C Virus- induced Hepatocellular Carcinoma
JinhwaLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 1 375-383 (9 pages)
a good target for molecular cancer therapy. Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection. This review describes CypA inhibitors as a potential HCC... good target for molecular cancer therapy. Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection. This review describes CypA inhibitors as a potential HCC treatment tool that is contrived by their obstructing chronic HCV infection and summarizes roles of CypA... -
Stress and language recovery in individuals with aphasia
Brian Sharp, Paige Shaughnessy, Lee Berk, Noha Daher 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 2호 6 92-98 (7 pages)
a total of 20 dif- ferent pictures. There was one pair of cards for each target item/stimulus. This activity was also conducted with two-to- three participants in each group. In this activity the partic- ipants were instructed to request a card that they had in their hand from another person in the group. The request had to be made verbally without the use of any non-verbal communi- cation. A... Objective: Constraint induced aphasia therapy (CIAT) is a more intensive form of language treatment for aphasia as compared to traditional treatments. This study examined whether there are differences in cortisol stress levels between the two methods of aphasia treatment as well as effects on language skills. Design: Randomized controlled trial. Methods: A total of 20 participants with expressive aphasia were randomly placed into one of the two treatment groups. The CIAT group received 10 days... -
Framework of Characterizing Scientific Claims of Elementary Pre-service Teachers in Their Science Journals
Shin Myeong-Kyeong 경인교육대학교 교육연구원 The Journal of Education 10 Pages
경인교육대학교 교육연구원 The Journal of Education 2019, Vol.2 No.1 2 15-24 (10 pages)
in elementary school as well. Keywords: science journal, science claims, elementary science inquiry Ⅰ. Introduction One of the target purpose of 2015 revision of Korean science curriculum is the critical thinking in science. It might be achieved by argument practice in school science. The core * First Author: Shin, Myeong-Kyeong (mkshin@ginue.ac.kr) ..PAGE:2 Shin, Myeong-Kyeong - 16 - of... This study aims to explore elementary pre-service teachers’ understanding of science practice in terms of claims in their science journals. Pre-service teachers took a science inquiry course and worked with self-directed inquiry by using Korean science elementary textbook. After inquiry activities, they provided science journals including their test question, data and claims on their inquiry. In order to characterize scientific claims, quality of question, data representation mode, claims were... -
“I’m Not Happy, But I Don’t Care”: Help-Seeking Behavior, Academic Difficulties, and Happiness
Hong Im Shin, Woo Taek Jeon 한국의학교육학회 Korean Journal of Medical Education 8 Pages
한국의학교육학회 Korean Journal of Medical Education 2011, 제 23권 제 1호 3 7-14 (8 pages)
the target population, 205 students (56.9%) returned the questionnaires. Of the 205 students who r e s p o n d e d , 1 3 0 s t u d e n t s ( 6 3 . 4 % ) w e r e m e n a n d 7 5 (36.5%) were women. The age ranged from 19 to 30 (M=22.9, SD=1.93) years. They were first-year to third- year medical students (M1, n=80; M2, n=71; M3, n=54). We constructed our questionnaire to identify types of d i... -
Cloning and characterization of a selenium-independent glutathione peroxidase (HC29) from adult Haemonchus contortus
Wei Sun, Xiaokai Song, Ruofeng Yan, Lixin Xu, Xiangrui Li* 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 8 49-58 (10 pages)
under reducing conditions (Fig. 6, Lanes 4∼8). Both the E. coli transformed with pET-28a and the cells transformed with recombinant plasmid before induction did not produce expressive target bands (Fig. 6, Lanes 1∼3). Western blot assay Native protein extracts of H. contortus probed with rat anti-recombinant HC29 serum displayed a single band with a size nearly the same as that of the... The complete coding sequence of Haemonchus (H.) contortus HC29 cDNA was generated by rapid amplification of cDNA ends in combination with PCR using primers targeting the 5´- and 3´-ends of the partial mRNA sequence. The cloned HC29 cDNA was shown to be 1,113 bp in size with an open reading frame of 507 bp, encoding a protein of 168 amino acid with a calculated molecular mass of 18.9 kDa. Amino acid sequence analysis revealed that the cloned HC29 cDNA contained the conserved catalytic triad and... -
Virulence factors and genetic variability of uropathogenic Escherichia coli isolated from dogs and cats in Italy
Clara Tramuta, Daniele Nucera, Patrizia Robino, Sara Salvarani, Patrizia Nebbia* 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 8 49-55 (7 pages)
the 8 target genes and was present in 34 isolates whose hosts included 25 dogs and 9 cats. The sfa gene was detected in 23 isolates from 16 dogs and 7 cats. The cnf1 gene was found in 21 isolates collected from 16 dogs and 5 cats, while the papC and iutA genes were found in 15 animals (11 dogs and 4 cats). The hlyA gene, detected in 11 isolates from 7 dogs and 4 cats, was always found in... In this study, the association between virulence genotypes and phylogenetic groups among Escherichia (E.) coli isolates obtained from pet dogs and cats with cystitis was detected, and fingerprinting methods were used to explore the relationship among strains. Forty uropathogenic E. coli (UPEC) isolated from dogs (n = 30) and cats (n = 10) in Italy were analysed by polymerase chain reaction (PCR) for the presence of virulence factors and their classification into phylogenetic groups. The same... -
Diagnosis of Helicobacter spp. infection in canine stomach
W. Prachasilpchai, S. Nuanualsuwan, T. Chatsuwan, S. Techangamsuwan, S. Wangnaitham, A. Sailasuta 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 2호 6 139-145 (7 pages)
as sampling location, specimen preparation, the choice of primers and target DNA, bacterial density and technical error, the DNA extraction step, or inhibitors of gastric juice and tissue may affect PCR detection [4]. In this study, canine gastric tissues were randomly collected from each part of the stomach with and without lesions. Primers and target DNA were selected based on an earlier study.... A total of 75 biopsied samples of cardia, fundus, body, and pyloric antrum from necropsied dogs that were submitted to the Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University from April 2003 to June 2004 were investigated. The objectives of this study were to determine the prevalence of Helicobacter spp. in canine stomach by polymerase chain reaction (PCR) in comparison to histochemistry versus immunohistochemistry (IHC), and to correlate these diagnostic methods... -
Isolation and identification of Escherichia coli O157:H7 using different detection methods and molecular determination by multiplex PCR and RAPD
Ji-Yeon Kim, So-Hyun Kim, Nam-Hoon Kwon, Won-Ki Bae, Ji-Youn Lim, Hye-Cheong Koo, Jun-Man Kim, Kyoung-Min Noh, Woo-Kyung Jung, K 대한수의학회 Journal of Veterinary Science 13 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 1호 2 7-19 (13 pages)
of the samples including non-target bacteria and other organic particles. The beads are then released by withdrawing the magnet. This simple step of IMS procedure can help us to isolate STEC from samples easily. Recently, immunomagnetic particles for the separation of E. coli O26 and O111 have become commercially available. With the use of IMS, the isolation rate of E. coli O157 has been markedly... Escherichia coli O157:H7 is recognized as a significant food-borne pathogen, so rapid identification is important for food hygiene management and prompt epidemiological investigations. The limited prevalence data on Shiga toxin-producing E. coli (STEC) and E. coli O157:H7 in foods and animals in Korea made an assessment of the risks difficult, and the options for management and control unclear. The prevalence of the organisms was examined by newly developed kit-E. coli O157:H7 Rapid kit. For the... -
Application and Effects of Music Appreciation Model for Emotional Development
Su-Young Bae 한국음악교육학회 음악교육연구 20 Pages
한국음악교육학회 음악교육연구 2021, 제 50권 제 2호 4 69-88 (20 pages)
a target and that there is no target in music except the music itself” (as cited in Hunter & Schellenberg, 2010, p. 131). Therefore, listeners simply feel whether they like or dislike the music, and the reason for them to say a music is happy or sad is not because that music makes them happy or sad, but because it expresses happiness or sadness. In contrast, most emotivist theories argue that... The purpose of this study was to find out the effects of applying the Music Appreciation Model for Emotional Development (MAMED). A qualitative case study approach was employed and data were collected through two self-reported emotion charts, two music appreciation reports, and one final reflection paper from each student. The results are first, 83.78% of the students answered that their emotional experiences were different in emotivist and cognitivist music listening conditions. Second, the... -
Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins
SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 8 531-546 (16 pages)
recent study suggested that TLRs mediate LPS signaling in target cells [23]. Although TLR-2 was reported to be involved in LPS signaling [24], the most essential receptor for LPS signaling is TLR-4 [25]. In arthritis mediated by the immune complex, TLR-4 modulates the early onset of immunity and cartilage destruction by increasing cytokine production and IL-10-mediated expression of Fc-gamma... Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24,and 36 h to induce TLR-4 activation. The...