자료유형
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Efficacy of horse chestnut leaf extract ALH-L1005 as a matrix metalloproteinase inhibitor in ligature-induced periodontitis in canine model
Se Eun Kim, Tae Hyun Kim, Shin Ae Park, Won Tae Kim, Young Woo Park, Jae Sang Ahn, Manbok Jeong, Min-Young Kim, Kangmoon Seo 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 15 245-251 (7 pages)
Matrix metalloproteinases (MMPs) are the main proteinases associated with periodontal tissue destruction and remodeling. Therefore, inhibition of host-derived MMPs has a key role in the prevention and reduction of periodontitis progression. Horse chestnut (Aesculus hippocastanum L.) extracts have been used as treatments for inflammatory disease, traditionally. This study assessed the clinical effect as a MMP inhibitor of horse chestnut leaf extract ALH-L1005 on periodontitis. ALH-L1005 was... -
Establishment of hydrochloric acid/lipopolysaccharide-induced pelvic inflammatory disease model
Yeonsu Oh, Jaehun Lee, Hyeon-Cheol Kim, Tae-Wook Hahn, Byung-Il Yoon, Jeong-Hee Han, Yong-Soo Kwon, Joung Jun Park, Deog-Bon Koo 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 3호 20 413-419 (7 pages)
Pelvic inflammatory disease (PID), which is one of the most problematic complications experienced by women with sexually transmitted diseases, frequently causes secondary infections after reproductive abnormalities in veterinary animals. Although the uterus is self-protective, it becomes fragile during periods or pregnancy. To investigate PID, bacteria or lipopolysaccharide (LPS) extracted from gram negative bacteria has been used to induce the disease in several animal models. However, when LPS... -
Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes
In-Jeoung Baek, Jung-Min Yon, Se-Ra Lee, Yan Jin, Mi-Ra Kim, Byeongwoo Ahn, Jin Tae Hong, Young-Kug Choo, Beom Jun Lee, Young Wo 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 3호 2 213-218 (6 pages)
Phospholipid hydroperoxide glutathione peroxidase (PHGPx), an antioxidative selenoprotein, is modulated by estrogen in the testis and oviduct. To examine whether potential endocrine disrupting chemicals (EDCs) affect the microenvironment of the testes, the expression patterns of PHGPx mRNA and histological changes were analyzed in 5-week-old Sprague-Dawley male rats exposed to several EDCs such as an androgenic compound [testosterone (50, 200, and 1,000 ?g/kg)], anti-androgenic compounds... -
Salt treatment for recovery of the mud loach, Misgurnus mizolepis from transport stress
Jin-ha Yu , Dae-hyun Kim , Jung-jo Han , Sung-woo Park , 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2016, 제 56권 제 4호 3 215-221 (7 pages)
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The anti-tumor effect of combined treatment with arsenic trioxide and interferone-α on transplanted murine Lewis Lung carcinoma
DeugLogSeo, JeHoonYang, ChungKilWon, MyeongOkKim, JongHwanLee, SooDongKwark, PhilOkKoh 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 1호 3 17-23 (7 pages)
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어머니와 교사가 보고한 유아기 외현화 문제행동의 발달경로에 미치는 기질의 영향
한국교육치료학회 교육치료연구 2016, Vol.8 No.2 9 291-310 (20 pages)
본 연구에서는 어머니와 교사의 반복 평가를 통해 유아기 외현화 문제행동 발달경로의 형태를 확인 하고, 이에 영향을 주는 유아 기질의 영향력을 검증하고자 하였다. 연구대상은 경기도에 거주하는 유아 165명이었다. 동시대집단 시계열설계를 적용하여 잠재성장곡선분석을 실시한 결과 첫째, 어머 니와 교사 모두 외현화 문제행동에 대해서는 선형적으로 감소하는 발달경로를 보고하였으나, 변화 율의 개인차는 어머니 보고 자료에서만 유의미하였다. 둘째, 외현화 문제행동 발달경로의 초기치에 영향을 주는 요인에 대해서 어머니 보고... -
The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain
MinJoonKim, JiHwanLee, JoUngJang, FuShiQuan, SunKwangKim, WoojinKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 11 657-666 (10 pages)
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced... -
Evaluation of fish oil-rich in MUFAs for anti-diabetic and anti-inflammation potential in experimental type 2 diabetic rats
WaranyaKeapai, SopidaApichai, DoungpornAmornlerdpison, NarissaraLailerd 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 13 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 4 581-593 (13 pages)
The advantages of monounsaturated fatty acids (MUFAs) on insulin resistance and type 2 diabetes mellitus (T2DM) have been well established. However, the molecular mechanisms of the anti-diabetic action of MUFAs remain unclear. This study examined the anti-hyperglycemic effect and explored the molecular mechanisms involved in the actions of fish oil- rich in MUFAs that had been acquired from hybrid catfish (Pangasius larnaudii×Pangasianodon hypophthalmus ) among experimental type 2 diabetic... -
Ameliorative Effect of a Selective Endothelin ETA Receptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia
GautamjeetSMangat, AmteshwarSJaggi, NirmalSingh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.3 2 201-209 (9 pages)
The present study was designed to investigate the efficacy of selective ETA receptor antagonist, ambrisentan on hyperhomocysteinemia-induced experimental vascular dementia. L-methionine was administered for 8 weeks to induce hyperhomocysteinemia and associated vascular dementia in male rats. Ambrisentan was administered to L-methionine-treated effect rats for 4 weeks (starting from 5th to 8th week of L-methionine treatment). On 52nd day onward, the animals were exposed to the Morris water maze... -
Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms
JoungHoonAhn, MinHyeKim, HyungJooKwon, SooYoungChoi, HyeokYilKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 7 43-50 (8 pages)
Palmitic acid (PAM), one of the most common saturated fatty acid (SFA) in animals and plants, has been shown to induce apoptosis in exocrine pancreatic AR42J cells. In this study, we investigated cellular mechanisms underlying protective effects of oleic acid (OLA) against the lipotoxic actions of PAM in AR42J cells. Exposure of cells to long-chain SFA induced apoptotic cell death determined by MTT cell viability assay and Hoechst staining. Co-treatment of OLA with PAM markedly protected cells... -
Oxygen/Glucose Deprivation and Reperfusion Cause Modifications of Postsynaptic Morphology and Activity in the CA3 Area of Organotypic Hippocampal Slice Cultures
YeonJooJung, EunChengSuh, KyungEunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 8 423-429 (7 pages)
Brain ischemia leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors, referred as excitotoxicity, which mediates neuronal cell death. However, less attention has been paid to changes in synaptic activity and morphology that could have an important impact on cell function and survival following ischemic insult. In this study, we investigated the effects of reperfusion after oxygen/glucose deprivation (OGD) not only upon neuronal cell death, but also on ultrastructural and biochemical... -
Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats
Ji-YoungJung, MootaekRoh, Kyung-KyunKo, Hwan-SooJang, , Seong-RyongLee, Jeoung-HeeHa, Il-SungJang, , Ho-WonLee, Maan-GeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 2 231-236 (6 pages)
determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not... -
Effects of Isoflurane Anesthesia on Post-Anesthetic Sleep-Wake Architectures in Rats
Hwan-SooJang, Ji-YoungJung, Kwang-HoJang, Maan-GeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 7 291-297 (7 pages)
The sleep homeostatic response significantly affects the state of anesthesia. In addition, sleep recovery may occur during anesthesia, either via a natural sleep-like process to occur or via a direct restorative effect. Little is known about the effects of isoflurane anesthesia on sleep homeostasis. We investigated whether 1) isoflurane anesthesia could provide a sleep-like process, and 2) the depth of anesthesia could differently affect the post-anesthesia sleep response. Nine rats were treated... -
Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates
Yuk-JaeChang, Won-KiLee, Hyung-GunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 8 129-133 (5 pages)
There are growing evidences suggesting a pivotal role of oxidative stress in the pathophysiology of preeclampsia. We investigated oxidative stress in the rat model of preeclampsia, and in clinical cases. Pregnant female rats were injected intraperitoneally with deoxycorticosterone acetate (DOCA) and given 0.9% saline as drinking water during their pregnancy. We assessed plasma F2-isoprostane (8-iso-PGF2α) and malondialdehyde (MDA) in a rat model, and the same markers in the plasma of maternal... -
Fragile Self and Malevolent Others
Hye Yoon Park, Minji Bang, Kyung Ran Kim, Eun Lee, Suk Kyoon An 대한신경정신의학회 Psychiatry Investigation 9 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 8 796-804 (9 pages)
Objective_Biased attribution styles of assigning hostile intention to innocent others and placing the blame were found in schizophrenia. Attribution styles in individuals at ultra-high risk (UHR) for psychosis, however, have been less studied especially for its association with various psychological factors. We investigated whether UHR individuals show increased hostility perception and blaming bias and explored the associations of these biased styles of attribution with the factor structure of... -
Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia
Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Kim, Seok Woo Moon, Jae Young 대한신경정신의학회 Psychiatry Investigation 8 Pages
대한신경정신의학회 Psychiatry Investigation 2018, 제 15권 제 8호 4 767-774 (8 pages)
Objective_Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from the Korean Health Industry Development Institute to investigate the epidemiology, biopsychosocial risk factors, and outcomes of dementia and dementia-related conditions. Methods_The KLOSCAD is the first nationwide multi-center population-based prospective cohort study.... -
정신분열병 환자에서 감정관리훈련의 효과
조현상, 이만홍, 최문종, 손석한, 최의헌, 이은철, 최태규, 김태용, 안혜리, 백민정, 유계준 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 6호 3 1223-1233 (11 pages)
연구목적： 인지와 정서의 기능장애로 정의되는 정신분열병은 정보처리와 관련되어 특히 긴장된 배경자극하에서 감정 적인(특히 부정적인) 자극이나 큐를 정확하게 인식하는데 어려움이 있으며, 감정이 심하게 부하된 상황에의 노 출이 재발의 원인이 된다. 이러한 정신분열병에 있어 정서 자체의 중요성에도 불구하고 사회적임성을 증진시 키는 기존의 기술훈련은 감정처리가 주 치료목표가 되지 못하고 감정부하 상황만이 주어졌다. 따라서 본 연구는 정서처리를 직접, 간접적으로 다루는 감정관리훈련(Emotional Management... -
정신의료서비스 제공량에 영향을 미치는 요인
김윤, 박종익, 강위창, 홍진표 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 5호 6 860-869 (10 pages)
연구목적： 정신병원에서 의료보호 환자의 장기 입원으로 인한 입원 진료비의 급격한 증가와 환자의 만성화를 억제하 기 위하여 새로운 일당진료비 지불제도를 시행할 예정이다. 이를 위하여 정신과 입원환자에 대한 서비스 제 공량에 영향을 미치는 요인을 규명하고자 하였다. 방 법： 조사대상 기관은 종합병원급 3개 병원과 정신병원급 3개 병원으로 6개 기관에서 총 575명을 무작위 층화 표본추출(stratified random sampling)하여 조사하였다. 조사 대상병원에서 재원기간별, 의료보장 유형별로 약 15∼20명 씩 조사대상을 정했다.... -
치매환자 부양자의 부양부담 결정인자
김재민, 신일선, 윤진상 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 6호 9 1106-1113 (8 pages)
연구목적： 연구는 국내 치매환자 부양자의 부양부담 결정인자를 조사하고자 하였다. 방 법： 79명의 치매환자 및 그 부양자에 대해, 부양부담척도와 부양부담에 영향을 미칠 수 있는 환자 및 부양자 관련 인자를 조사하였다. 각 인자와 부양부담과의 관련성을 uni- 또는 bi-variate analyses로 검증한 다음, 부양 부담의 결정인자를 알아보기 위해 stepwise multiple linear regression analyses를 시행하였다. 결 과： ‘환자의 심한 우울증상’과‘부양자의 낮은 자발적 부양동기’가 부양부담의 결정인자로 확인되었다. 결정인 자는...
