자료유형
발행기관
- 대한신경정신의학회(21)
- 대한생리학회-대한약리학회(12)
- 한국식품영양과학회(3)
- 대한수의학회(2)
- 대한한의학회(2)
- 한국노년학연구회(2)
- 한국생명과학회(2)
- 한국식품과학회(2)
- 한국웰니스학회(2)
- 경희한의학연구센터(1)
- 고령자치매작업치료학회(1)
- 대한생물정신의학회(1)
- 대한소아신장학회(1)
- 생화학분자생물학회(1)
- 우리말학회(1)
- 한국노인간호학회(1)
- 한국미술치료학회(1)
- 한방비만학회(1)
간행물
- 신경정신의학(17)
- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(12)
- PSYCHIATRY INVESTIGATION(4)
- FOOD SCIENCE AND BIOTECHNOLOGY(2)
- 대한한의학회지(2)
- 생명과학회지(2)
- 한국노년학연구(2)
- 한국식품영양과학회지(2)
- 한국웰니스학회지(2)
- JOURNAL OF MEDICINAL FOOD(1)
- JOURNAL OF VETERINARY SCIENCE(1)
- KOREAN JOURNAL OF VETERINARY RESEARCH(구 대한수의학회지)(1)
- ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE : OPEM(1)
- 고령자-치매작업치료학회지(1)
- 노인간호학회지(1)
- 대한소아신장학회지(1)
- 대한한방비만학회지(1)
- 미술치료연구(1)
- 생물정신의학(1)
- 우리말연구(1)
- 한국생화학회지(1)
전체 선택해제
총 57건 검색
본문검색 결과만 보기
-
뇌영상기법과 ApoE 유전자형 분석을 통한 경도인지저하환자에서 치매 전환으로의 구조학적, 유전학적 변이 연구
김지현, 김연하, 김희진 고령자치매작업치료학회 고령자·치매작업치료학회지 7 Pages
고령자치매작업치료학회 고령자·치매작업치료학회지 2019, 제 13권 제 2호 1 1-7 (7 pages)
2.4였고, 1년의 종적인 뇌구조의 변화를 관찰할 때 뇌의 위축은 ApoE ε4 allele형을 가진 치매전환군에서 왼쪽 측두엽과 양측 두정엽에서 저명하였다. 결론 : 경도인지장애군을 치매로 전환시키는 교정인자는 운동여부과 흡연력과 독거 등의 위험요소가 위험 인자였고, 생물학적인 인자는 나이와 ApoE ε4 allele와 환자가 가지고 있는 내과적 질환은 기존의 보고와는 다르게 치매 전환에 대한 영향은 유의하지 않았다. 따라서 이번 연구를 통하여 고위험군의 색출과 함께 사회통합적인 교정인자의 조기 개입이 중요함을 알 수 있었다. -
고콜레스테롤혈증 ApoE Knockout 마우스에서 기능성 수정과의 지질과산화 및 산화적 DNA 손상 억제 효과
박은주, 백아란, 김미정, 이선우, 이은지, 최미주, 이지현, 송영옥, Park. Eunju, Baek. Aran, Kim. Mijeong, Lee. Seon Woo, Lee. Eunji, Choi. Mi-Joo, Lee. Jeehyun, Song. Yeo 한국식품영양과학회 한국식품영양과학회지 8 Pages
한국식품영양과학회 한국식품영양과학회지 2014, Vol.43 No.11 1627-1634 (8 pages)
음료의 항산화 및 산화적 DNA 손상억제 효능을 살펴보고자 하였다. 고콜레스테롤식이 공급으로 고콜레스테롤혈증이 유발된 10주령의 ApoE KO 마우스를 대조군인 설탕물 섭취군(Control), 설탕 첨가 수정과 음료 섭취군(Sucrose), 스티비아 첨가 수정과 음료 섭취군(Stevia), scFOS 첨가 수정과 음료 섭취군(scSFO), 그리고 양성대조군으로 시판 수정과를 섭취시킨 군(Positive control)으로 나누어 실험 식이를 6주간 공급한 후, 혈장 TRAP, 혈장 및 간의 TBARS, 백혈구, 간세포 및 비장세포의 내재적 또는 산화적 스트레스로 인한 DNA... -
동맥경화증이 유발된 $ApoE^{(-/-)}$ mouse에서 혈부축어탕(血府逐瘀湯)과 Aspirin의 병용투여 효과에 대한 연구
이범준, 윤승연, 박현우, 박지혁, 조인영, 이정숙, 류재환, Lee. Beom-Joon, Yun. Seung-Yeon, Park. Hyun-Woo, Park. Ji-Hyuk, Jo. In-Young, Lee. Jeong-Sook, Lew. Jae-Hw 대한한의학회 大韓韓醫學會誌 11 Pages
대한한의학회 大韓韓醫學會誌 2011, Vol.32 No.1 164-174 (11 pages)
-
동맥경화증이 유발된 $ApoE^{(-/-)}$ mouse에서 소풍활혈탕(疎風活血湯)과 Clopidogrel의 병용투여 효과에 대한 연구
이범준, 오세춘, 김영찬, 이정숙, 강덕희, 이우경, 이영일, 류재환, Lee. Beom-Joon, Oh. Sae-Choon, Kim. Young-Chan, Lee. Jeong-Sook, Kang. Deok-Hee, Lee. Woo-Kyoung, Lee. 대한한의학회 大韓韓醫學會誌 12 Pages
대한한의학회 大韓韓醫學會誌 2010, Vol.31 No.5 124-135 (12 pages)
-
Effect of Citrus Pectin Oligosaccharide Prepared by Irradiation on High Cholesterol Diet B6.KOR-ApoE Mice
Kang. Ho-Jin, Kwon. Joong-Ho, Ahn. Dong-Uk, Lee. Ju-Woon, Lee. Wan-Kyu, Jo. Cheo-Run 한국식품과학회 Food science and biotechnology 5 Pages
한국식품과학회 Food science and biotechnology 2009, Vol.18 No.4 884-888 (5 pages)
-
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
비만 유전자 단일 염기 다형성 문헌 고찰
송희옥(Hee Ok Song), 김성수(Sung Soo Kim) 한방비만학회 대한한방비만학회지 22 Pages
한방비만학회 대한한방비만학회지 2004, 제 4권 제 1호 12 139-160 (22 pages)
-
Morroniside on anti-inflammation activities in rats following acute myocardial infarction
BangxingYu, GuoxingZhang, YiAn, WenWang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 2 17-21 (5 pages)
Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and... -
Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice
MinhCongNguyen, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 10 83-90 (8 pages)
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the activity of endothelial nitric oxide synthase (eNOS) and limits NO generation. Hence, arginase inhibition is suggested to be vasoprotective in aging. In this study, we examined the effects of intravenous injection of Piceatannol, an arginase inhibitor, on aged mice. Our results show that Piceatannol... -
Regulation of vascular smooth muscle phenotype by cross-regulation of krüppel-like factors
JungMinHa, SungJiYun, SeoYeonJin, HyeSunLee, SunJaKim, HwaKyoungShin, SunSikBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 5 37-44 (8 pages)
Regulation of vascular smooth muscle cell (VSMC) phenotype plays an essential role in many cardiovascular diseases. In the present study, we provide evidence that krüppel-like factor 8 (KLF8) is essential for tumor necrosis factor α (TNFα)-induced phenotypic conversion of VSMC obtained from thoracic aorta from 4-week-old SD rats. Stimulation of the contractile phenotype of VSMCs with TNFα significantly reduced the VSMC marker gene expression and KLF8. The gene expression of KLF8 was... -
Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells
XiaoliRan, WenwenZhao, WenpingLi, JingshanShi, XiupingChen 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 4 347-355 (9 pages)
Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor alpha (TNF-α) induced lectin-like receptor for oxidized low density lipoprotein (LOX-1) were investigated. Human umbilical vein endothelial cells (HUVECs) were cultured and the effect of TNF-α on LOX-1 expression at mRNA and protein levels was determined by Real-time PCR and... -
Role of Nucleotide-binding and Oligomerization Domain 2 Protein (NOD2) in the Development of Atherosclerosis
Ha-JeongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 1 479-484 (6 pages)
NOD2 (nucleotide-binding and oligomerization domain 2) was initially reported as a susceptibility gene for Crohn’s disease, with several studies focused on elucidating its molecular mechanism in the progression of Crohn’s disease. We now know that NOD2 is an intracellular bacterial sensing receptor, and that MDP-mediated NOD2 activation drives inflammatory signaling. Various mutations in NOD2 have been reported, with NOD2 loss of function being associated with the development of Crohn’s... -
Role of Cerebrospinal Fluid Biomarkers in Clinical Trials for Alzheimer’s Disease Modifying Therapies
Ju-HeeKang, Na-YoungRyoo, DongWunShin, JohnQTrojanowski, LeslieM.Shaw 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 1 447-456 (10 pages)
Until now, a disease-modifying therapy (DMT) that has an ability to slow or arrest Alzheimer’s disease (AD) progression has not been developed, and all clinical trials involving AD patients enrolled by clinical assessment alone also have not been successful. Given the growing consensus that the DMT is likely to require treatment initiation well before full-blown dementia emerges, the early detection of AD will provide opportunities to successfully identify new drugs that slow the course of AD... -
Korean Red Ginseng Water Extract Restores Impaired Endothelial Function by Inhibiting Arginase Activity in Aged Mice
KwanhoonChoi, JeongyeonYoon, HyunKyoLim, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.2 2 95-102 (8 pages)
Cardiovascular disease is the prime cause of morbidity and mortality and the population ages that may contribute to increase in the occurrence of cardiovascular disease. Arginase upregulation is associated with impaired endothelial function in aged vascular system and thus may contribute to cardiovascular disease. According to recent research, Korean Red Ginseng water extract (KRGE) may reduce cardiovascular disease risk by improving vascular system health. The purpose of this study was to... -
Ginsenoside Rg2 Inhibits Lipopolysaccharide-Induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cell
Young-SukCho, ChanHyungKim, Tae-SunHa, SangJinLee, HeeYulAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 4 133-137 (5 pages)
Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has been used for prevention of illness in Korea. In this study, we investigated the mechanism(s) by which ginsenoside Rg2 may inhibit VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS) in human umbilical vein endothelial cell... -
Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase
WoosungShin, ToDaoCuong, JeongHyungLee, ByungsunMin, ByeongHwaJeon, HyunKyoLim, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.3 1 123-128 (6 pages)
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of C. sappan (CLE) showed inhibitory activity on arginase which has recently been reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. CLE inhibited arginase II activity prepared from kidney lysate in a dose-dependent manner. In HUVECs,... -
HO-1 Induced by Cilostazol Protects Against TNF-α-associated Cytotoxicity via a PPAR-γ-dependent Pathway in Human Endothelial Cells
SoYounPark, JinUngBae, KiWhanHong, ChiDaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 2 83-88 (6 pages)
A large body of evidence has indicated that induction of endogenous antioxidative proteins seems to be a reasonable strategy for delaying the progression of cell injury. In our previous study, cilostazol was found to increase the expression of the antioxidant enzyme heme oxygenase-1 (HO-1) in synovial cells. Thus, the present study was undertaken to examine whether cilostazol is able to counteract tumor necrosis factor-Ձ (TNF-Ձ)-induced cell death in endothelial cells via the... -
Neurovascular Mechanisms in Stroke, Neurodegeneration and Recovery
EngH.Lo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 1 223-230 (8 pages)
The emerging concept of the“neurovascular unit”may enable a powerful paradigm shift for neuroscience. Instead of a pure focus on the“neurobiology”of disease, an opportunity now exists to return to a more integrative approach. The neurovascular unit emphasizes that signaling between vascular and neuronal compartments comprise the basis for both function and dysfunction in brain. Hence, brain disorders are not just due to death of neurons, but instead manifested as cell signaling perturbations...
