자료유형
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- 대한생리학회-대한약리학회(58)
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- THE KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY(58)
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전체 선택해제
총 107건 검색
본문검색 결과만 보기
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Extracts of Aster species Inhibit Invasive Phenotype and Motility of H-ras MCF10A Human Breast Epithelial Cells Possibly via Downregulation of MMP-2 and MMP-9
Ahn. Seong-Min, Lee. Kang-Ro, Moon. A-Ree 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 6 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 2002, Vol.10 No.4 240-245 (6 pages)
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Lack of Mutation in p53 and H-ras Genes in Phenytoin Induced Gingival Overgrowth Suggests its Non Cancerous Nature
Jayaraman. Bhaskar, Valiathan. Gopalakrishnan Mohan, Jayakumar. Keerthivasan, Palaniyandi. Arunmozhi, Thenumgal. Siji Jacob, Ramanath 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 4 Pages
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP 2012, Vol.13 No.11 5535-5538 (4 pages)
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Type I Collagen-induced Pro-MMP-2 Activation is Differentially Regulated by H-Ras and N-Ras in Human Breast Epithelial Cells
Kim. In-Young, Jeong. Seo-Jin, Kim. Eun-Sook, Kim. Seung-Hee, Moon. A-Ree 생화학분자생물학회 Journal of biochemistry and molecular biology 7 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2007, Vol.40 No.5 825-831 (7 pages)
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Rapid Detection of H-RAS Point Mutation Using Two-Step Polymerase Chain Reaction-Restriction Fragment Length Polymorphism
Park. Young-Suk, Lee. Kyung-Ok, Chai. Young-Gyu 생화학분자생물학회 Journal of biochemistry and molecular biology 6 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 1996, Vol.29 No.5 442-447 (6 pages)
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DMBA 매식과 방사선 조사로 유도된 백서 타액선 종양에서 H-ras 암유전자의 활성화
허기수, 최종환, 최순철, 박태원, 유동수, Hu. Key-Soon, Choi. Jong-Whan, Choi. Soon-Chul, Park. Tae-Won, You. Dong-Soo 대한구강악안면방사선학회 齒科放射線 15 Pages
대한구강악안면방사선학회 齒科放射線 1998, Vol.28 No.1 245-259 (15 pages)
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Capsaicin-Induced Apoptosis of H-Ras-Transformed Human Breast Epithelial Cells is Rac-Dependent via ROS Generation
Kim. Seon-Hoe, Moon. Aree 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 5 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2004, Vol.27 No.8 845-849 (5 pages)
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Inhibition of Invasion and Induction of Apoptosis by Curcumin in H-ras-Transformed MCF10A Human Breast Epithelial Cells
Kim. Mi-Sung, Kang. Hye-Jung, Moon. Aree 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2001, Vol.24 No.4 349-354 (6 pages)
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Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy
HyunjuKim, NariKim, HyunJoo, JaeBoumYoum, WonSunPark, MohamedWarda, SunghyunKang, VuThiThu, TranMinhKhoa, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 7 299-304 (6 pages)
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we examined the molecular mechanism of isoproterenol (ISO)-evoked activation of Ras/Raf/MAPK pathways as well as PKA activity in cerebral artery of rabbits, and we also studied whether the activations of these signaling pathways were altered in cerebral artery,... -
인체 상피세포에서 ras-종양유전자의 발암화가 신호 전달 기작에 미치는 영향
장도근, 변기정, 김진수, Jang. Do-Geun, Byeon. Ki-Jeong, Kim. Chin-Soo 대한구강악안면외과학회 大韓口腔顎顔面外科學會誌 8 Pages
대한구강악안면외과학회 大韓口腔顎顔面外科學會誌 2000, Vol.26 No.3 254-261 (8 pages)
신호전달기작의 down-regulation이 관여하고 있음을 보여주고 있다. 성장조절인자의 mRNA 발현을 평가한 결과 $TGF-{eta}_1$ 및 PAI-2의 발현은 발암세포에서 낮게 나타난 반면 fibronectin의 경우는 발암세포의 발현이 높게 나타났다. 이러한 결과는 H-ras 종양유전자에 의한 발암화 과정에 성장조절인자의 변화가 관여하고 있으며 이러한 성장조절인자의 확인은 암발생의 생물학적 지표를 선별하는 데 기여할 것으로 사료된다. 본 연구는 H-ras 종양유전자에 의한 인체세포 발암화의 확인과 발암화 과정에 관여하는 신호전달기작의 변화 및... -
CB6F1-Tg rasH2 Mouse Carrying Human Prototype c-Ha-ras Gene As an Alternative Model For Carcinogenicity Testing For Pharmaceuticals
Usui. T., Urano. K., Suzuki. S., Hioki. K., Maruyama. Ch., Tomisawa. M., Ohnishi. Y., Suemizu. H., Yamamoto. S. 한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 5 Pages
한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 2001, Vol.17 293-297 (5 pages)
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Merlin Represses Ras-Induced Cyclin D1 Transcription through the Cyclic AMP-Responsive Element
Noh-JinKwak, HongtaeKim, ByungHyuneChoi, YoungHoonKim, HyoungKyunRha, Kweon-HaengLee, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.5 8 289-293 (5 pages)
Mutations in the NF2 tumor suppressor gene cause neurofibromatosis type 2, an autosomal dominant inherited syndrome predisposed to the multiple tumors of the nervous system. Merlin, the NF2 gene product was reported to block Ras-mediated cell transformation and represses Ras-induced expression of cyclin D1. However, the potential mechanism underlying the anti-Ras function of merlin on the cyclin D1 is still unclear. In this study, we investigated whether merlin decreases Ha-ras-induced... -
Chronic Treatment of Ethanol Inhibits Proliferation of Normal Fibroblasts, but Not Oncogenic ras-Transformed Cells
Gu. Young-Hwa, Park. Mi-Sun, Jhun. Byung-H. 한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 6 Pages
한국응용약물학회 The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmaco 1998, Vol.6 No.4 345-350 (6 pages)
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Role of Caveolin-1 in Indomethacin-induced Death of Human Hepatoadenocarcinoma SK-Hep1 Cells
Kyung-NamKim, Ju-HeeKang, Sung-VinYim, Chang-ShinPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 3 143-148 (6 pages)
Caveolin-1 (CAV1) is an integral membrane protein that may function as a scaffold for plasma membrane proteins and acts as a tumor suppressor protein. One causative factor of chemotherapy- resistant cancers is P-plycoprotein (P-gp), the product of the multidrug resistance-1 gene (MDR1), which is localized in the caveolar structure. Currently, the interactive roles of CAV1 and MDR1 expression in the death of cancer cells remain controversial. In this study, we investigated the effects of... -
Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
Hongyan Zhao, Wei Liu, Yi Wang, Nannan Dai, Jianhong Gu, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zong-Ping Liu 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 7 297-306 (10 pages)
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell viability, damaged cell membranes and induced apoptosis in OBs. We observed decreased mitochondrial transmembrane potentials, ultrastructure collapse, enhanced caspase-3 activity, and increased concentrations of cleaved PARP, cleaved caspase-9 and cleaved caspase-3 following Cd treatment.... -
식이 Capsaicin이 마우스의 주요 장기조직에서의 Proto-oncogenes Expression에 미치는 영향
김정미, 한인섭, 김병삼, 유리나 한국식품영양과학회 한국식품영양과학회지 7 Pages
한국식품영양과학회 한국식품영양과학회지 1996, Vol.25 No.6 1024-1030 (7 pages)
20, 100ppm이 되도록 조제한 먹이로 4주 동안 사육하였다. 사육기간 종료 후 동물들의 중요장기를 적출하여 total RNA를 분리하고, proto-oncogene(c-jun, c-myc, H-ras, erbB, p53)의 발현 수준을 slot blot hybridization assay를 통해 살펴 보았다. 이때, control probe로는 18SrRNA를 사용하였다. 그 결과, c-jun proto-oncogene의 발현은 각 주요 장기조직에 따라 다른 양상을 나타내었는데, 식이CAP 투여량이 증가함에 따라 간과 신장에서 그 발현이 증가하며, 위에서는 CAP 20ppm까지는 c-jun의 발현이 증가하다. 100ppm 투여시에... -
Farnesyl transferase 억제제인 YH3938 및 YH3945에 의한 Ras 발암원성 억제
오명주, 김농연, 임수은, 정영화, 전병학, Oh. Myung-Ju, Kim. Nong-Yeon, Lim. Su-Eun, Chung. Young-Hwa, Jhun. Byung-H. 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2010, Vol.20 No.2 202-207 (6 pages)
변화를 억제하였으나 K-Ras에 대해서는 효과가 없었다. N-Ras에 대해서는 약한 영향이 있었다. H-Ras와 N-Ras에 의한 SRE promoter 활성화는 YH3938과 YH3945에 의해 억제되었으나, K-Ras에는 영향이 없었다. Ras 단백질의 bandshift 분석을 통해 YH3938은 H-Ras와 N-Ras의 번역 후 변환을 억제하였으나, K-Ras에는 영향이 없었다. YH3945는 H-Ras의 변환에만 영향이 있었다. 결론적으로 YH3938과 YH3945는 H-Ras의 farnesylation을 억제하여 그 발암원성을 억제하며, YH3938은 N-Ras 작용을 농도의존적으로 억제하며, K-ras에 대해서는... -
Whole-genome sequence of Mycobacterium bovis strain B-3222 isolated from Korean beef cattle in bTB-infected herd
Na-rae Kim, Mi Hye Hwang, Yun-ho Jang, So-yoon Ryoo, Shin Seok Kang, Hyeon Seop Byeon, Hee Soo Lee, Young Hee Lim, Jae Myung Kim 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 49 109-110 (2 pages)
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Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells
Hyun Sun Cho, Seung Hee Chang, Youn Sun Chung, Ji Young Shin, Sung Jin Park, Eun Sun Lee, Soon Kyung Hwang, Jung Taek Kwon, Aras 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 4 23-28 (6 pages)
Tetrandrine (TET), a bis-benzylisoquinoline alkaloid from the root of Stephania tetrandra, is known to have anti-tumor activity in various malignant neoplasms. However, the precise mechanism by which TET inhibits tumor cell growth remains to be elucidated. The present studies were performed to characterize the potential effects of TET on phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase (ERK) pathways since these signaling pathways are known to be responsible for cell... -
Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats
Jia Hao, Chan-Hyung Kim, Tae-Sun Ha, Hee-Yul Ahn 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 2호 4 121-129 (9 pages)
Pressure overload diseases, such as valvular stenosis and systemic hypertension, manifest morphologically in patients as cardiac concentric hypertrophy. Prevention of cardiac remodeling due to increased pressure overload is important to reduce morbidity and mortality. Epigallocatechin-3 gallate (EGCG) is a major bioactive polyphenol present in green tea which has been found to be a nitric oxide-mediated vasorelaxant and to be cardioprotective in myocardial ischemia-reperfusion injury. Therefore,... -
Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells
Seo-Hyun Moon, Hyun-Woo Kim, Jun-Sung Kim, Jin-Hong Park, Hwa Kim, Gook-Jong Eu, Hyun-Sun Cho, Ga-Mi Kang, Kee-Ho Lee, Myung-Hai 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 13 369-378 (10 pages)
Evidences show that eukaryotic mRNAs can perform protein translation through internal ribosome entry sites (IRES). 5'-Untranslated region of the mRNA encoding apoptotic protease-activating factor 1 (Apaf-1) contains IRES, and, thus, can be translated in a cap-independent manner. Effects of changes in protein translation pattern through rapamycin pretreatment on 4-(methylnitrosamino)-1-(3-pyridyl)-butanone(NNK, tobacco-specific lung carcinogen)-induced apoptosis in human bronchial epithelial... -
Expression of caveolin-3 as positive intracellular signaling regulator on the development of hypertrophy in cardiac tissues
JooHeonKim, JinHan, YongKwonKim, YoungAeYang, YongGeunHong 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 4호 12 537-544 (8 pages)
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NecroX-5 protects mitochondrial oxidative phosphorylation capacity and preserves PGC1α expression levels during hypoxia/ reoxygenation injury
VuThiThu, HyoungKyuKim, LeThanhLong, BayalagmaaNyamaa, In-SungSong, ToThanhThuy, NguyenQuangHuy, JubertMarquez, SoonHaKim, NariKim, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 9 201-211 (11 pages)
Although the antioxidant and cardioprotective effects of NecroX-5 on various in vitro and in vivo models have been demonstrated, the action of this compound on the mitochondrial oxidative phosphorylation system remains unclear. Here we verify the role of NecroX-5 in protecting mitochondrial oxidative phosphorylation capacity during hypoxia-reoxygenation (HR). Necrox-5 treatment (10 μM) and non-treatment were employed on isolated rat hearts during hypoxia/ reoxygenation treatment using an ex... -
Brief low [Mg2+]o-induced Ca2+ spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons
HeeJungKim, JiSeonYang, ShinHeeYoon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 13 101-109 (9 pages)
Reducing [Mg2+]o to 0.1 mM can evoke repetitive [Ca2+]i spikes and seizure activity, which induces neuronal cell death in a process called excitotoxicity. We examined the issue of whether cultured rat hippocampal neurons preconditioned by a brief exposure to 0.1 mM [Mg2+]o are rendered resistant to excitotoxicity induced by a subsequent prolonged exposure and whether Ca2+ spikes are involved in this process. Preconditioning by an exposure to 0.1 mM [Mg2+]o for 5 min inhibited significantly... -
Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells
Ji-HongLim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.5 6 391-396 (6 pages)
Although interleukin-11 (IL-11) has been reported to be elevated in hypoxic tumors and has been associated with a poor prognosis in various cancers, little is known about its precise role in promoting metastasis in hypoxic tumors. In the present study, the molecular mechanism underlying the effects of IL-11 on MDA-MB-231 breast cancer cells migration and invasion in relation to metastasis under hypoxic conditions has been defined. Inhibition of IL-11 expression or function using small... -
High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2
YuMiHa, DongHyupLee, MinaKim, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 8 307-314 (8 pages)
Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator in the fibrotic action of transforming growth factor Ղ (TGFՂ) and is potentially induced by hyperglycemia in human vascular smooth muscle cells (VSMCs). Therefore, the goal of this study is to identify the signaling pathways of CTGF effects on ECM... -
Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation
DongHyupLee, JungEunKim, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.2 7 157-162 (6 pages)
Insulin-like growth factor binding proteins (IGFBPs) are important components of insulin growth factor (IGF) signaling pathways. One of the binding proteins, IGFBP-5, enhances the actions of IGF-1, which include the enhanced proliferation of smooth muscle cells. In the present study, we examined the expression and the biological effects of IGFBP-5 in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). The levels of IGFBP-5 mRNA and protein...
