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총 599건 검색
본문검색 결과만 보기
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탄화수소계 냉매 R-290을 사용하는 냉동.공조 장치의 사이클 특성에 관한 연구
박기원 한국마린엔지니어링학회 韓國舶用機關學會誌 6 Pages
한국마린엔지니어링학회 韓國舶用機關學會誌 1999, Vol.23 No.4 447-452 (6 pages)
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마이크로 휜 증발관내 냉매 R-290의 열전달 특성에 미치는 냉동유의 영향
박철민, 안영태, 이욱현, 김정훈, 김종수, Park. Cheol-Min, An. Young-Tae, Lee. Wook-Hyun, Kim. Jeung-Hoon, Kim. Jong-Soo 대한기계학회 大韓機械學會論文集. Transactions of the Korean society of mechanical engineers. B. B 7 Pages
대한기계학회 大韓機械學會論文集. Transactions of the Korean society of mechanical engineers. B. B 2000, Vol.24 No.7 938-944 (7 pages)
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자연냉매 (R-290)를 이용한 식품 냉동기
김내현, 박형채, Kim. Nae-Hyeon, Park. Hyeong-Chae 대한설비공학회 설비저널 6 Pages
대한설비공학회 설비저널 2007, Vol.36 No.7 20-25 (6 pages)
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프로판/이소부탄(R-290/R-600a) 혼합 냉매를 적용한 가정용 소형 멀티 냉동시스템의 성능특성에 관한 연구
김상욱, 이무연, Kim. Sanguk, Lee. MooYeon 대한기계학회 大韓機械學會論文集. Transactions of the Korean society of mechanical engineers. B. B 8 Pages
대한기계학회 大韓機械學會論文集. Transactions of the Korean society of mechanical engineers. B. B 2005, Vol.29 No.2 271-278 (8 pages)
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Nimodipine as a Potential Pharmacological Tool for Characterizing R-Type Calcium Currents
SeogBaeOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.6 8 511-519 (9 pages)
Nimopidine, one of dihydropyridine derivatives, has been widely used to pharmacologically identify L-type Ca currents. In this study, it was tested if nimodipine is a selective blocker for L-type Ca currents in sensory neurons and heterologous system. In mouse dorsal root ganglion neurons (DRG), low concentrations of nimodipine (＜10μM), mainly targeting L-type Ca currents, blocked high-voltage-activated calcium channel currents by ∼38%. Interestingly, high concentrations of nimodipine... -
R-러닝 유아 언어발달 평가도구 개발을 위한 기초연구
최연철, 서윤희 한국어린이미디어학회 어린이미디어연구 35 Pages
한국어린이미디어학회 어린이미디어연구 2014, 제 13권 제 1호 12 277-311 (35 pages)
본 연구의 목적은 R-러닝이 유아의 언어발달에 미치는 영향을 타당하게 평가할 수 있는 평가도구 개 발을 위한 탐색을 하는 것이다. 이를 위해 R-러닝 언어발달 영향평가와 관련된 선행연구를 통해 기존 의 연구에서 사용한 언어발달 평가도구들을 분석하였으며, R-러닝과 유아 언어발달과 관련된 질적 연 구 분석 및 교사 대상 개방형 설문을 통해 R-러닝과 유아 간 상호작용에서 나타나는 언어적 상호작용 의 특성을 분석하였다. 분석 결과, R-러닝 유아 언어발달 영향평가 도구를 개발하기 위해서는 첫째, R-러닝을 기반으로 유아의... -
R-러닝에 대한 부모의 인식 및 요구
이연승, 조재경 한국어린이미디어학회 어린이미디어연구 21 Pages
한국어린이미디어학회 어린이미디어연구 2013, 제 12권 제 2호 1 1-21 (21 pages)
본 연구는 R-러닝에 대한 부모의 인식 및 요구를 조사하여, R-러닝에 대한 부모의 다양한 요구에 부 합하는 보다 효율적인 R-러닝이 시행 될 수 있는 발전 방향을 제시하기 위하여, R-러닝을 시행하고 있는 유치원 어머니 327명을 대상으로 설문 조사를 실시하였다. 연구 결과 어머니들은 대체적으로 로 봇을 경험하였으며, R-러닝이 유아들에게 유용할 것이라고 생각한다고 나타났다. 또한 어머니들의 일 반적 배경에 따른 R-러닝의 인식과 요구에 유의미한 차이를 나타내었다. 본 연구결과를 토대로, 지속 적인 R-러닝의 확대를... -
Effects of relaxation approach with self-exercise on head posture, static postural stability, and headache in persons with tension-type headache
Sang-Yong Park, Su-jin Hwang 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 4호 3 178-184 (7 pages)
Objective: Tension-type headache is caused by hormones, foods, irritants, stress, obesity, fatigue, and neck and head trigger points-prolonged abnormal posture. The purpose of this study was to evaluate the effects of relaxation approach on head posture, static postural stability, and headache in persons with tension-type headache. Design: Randomized controlled trial. Methods: Thirty-five persons with tension-type headache participated in this study. This study was a pretest-posttest with a... -
Activation of autophagic flux induced by Epigallocatechin gallate (EGCG) mitigates TRAIL-induced tumor cell apoptosis via down-regulation of death receptors
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Multiplex reverse transcription loop-mediated isothermal amplification assay for the rapid detection of M and H5 gene of avian influenza viruses
Yu Ri Park, Da Rae Lim, Hye Ryung Kim, Min Ji Park, Sang Geon Yeo, Choi Kyu Park 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 149 290-291 (2 pages)
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Multiplex reverse-transcription loop-mediated isothermal amplification (mRT-LAMP) assay for differential detection of porcine reproductive and respiratory syndrome viruses
Min Ji Park, Yu Ri Park, Da Rae Lim, Hye Ryung Kim, Seong Hee Kim, Kyoung Ki Lee, Choi Kyu Park, Ji Young Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 148 290-290 (1 pages)
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A two-component signal transduction system contributes to the virulence of Riemerella anatipestifer
Qing Wang, Mianmian Chen, Wei Zhang 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 2호 12 260-270 (11 pages)
Similar to other studies of bacterial pathogens, current studies of the pathogenesis of Riemerella anatipestifer (RA) are focused mainly on in vitro culture conditions. To elucidate further the pathogenesis of RA in vivo, bacterial RNA was extracted from overnight tryptic soy broth cultures (in vitro) and from the blood of infected ducks (in vivo) for comparative RNA sequencing analysis. In total, 682 upregulated genes were identified in vivo. Among the upregulated genes, a signal transduction... -
Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
Ihsan Ali, Syed Zahid Ali Shah, Yi Jin, Zhong-Shu Li, Obaid Ullah, Nan-Zhu Fang 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 1 1-9 (9 pages)
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic development with the increase in protein requirements for cell survival and growth. The ER is a multifunctional cellular organelle responsible for protein folding, modification, and cellular homeostasis. ER stress is activated by a variety of factors including... -
Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model
Joongsun Kim, Sunhoo Park, Byung-Suk Jeon, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Kyung-Jin Rhim, Soong In Lee, Seung-Sook L 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 4호 1 435-444 (10 pages)
Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study, the effects of topical curcumin treatment on radiation burns were evaluated in a mini-pig model. Histological and clinical changes were observed five weeks after radiation exposure to the back (Co gamma-radiation, 50 Gy). Curcumin was applied topically to irradiated skin... -
Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats
Hyo-jin Chung, Wook-hun Chung, Jae-Hoon Lee, Dai-Jung Chung, Wo-Jong Yang, A-Jin Lee, Chi-Bong Choi, Hwa-Seok Chang, Dae-Hyun Ki 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 12 97-102 (6 pages)
We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI... -
Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
Bratislav Dejanovic, Ivana Stevanovic, Milica Ninkovic, Ivana Stojanovic, Irena Lavrnja, Tatjana Radicevic, Milos Pavlovic 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 7 53-61 (9 pages)
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of antioxidant protection in the brain homogenates of forebrain cortexes prepared 48 h after treatment were investigated. Chlorpromazine was applied intraperitoneally (i.p.) in single dose of 38.7 mg/kg body weight (BW) The second group was treated with both CPZ... -
Influence of category−heifers, primiparous and multiparous lactating cows−in a large-scale resynchronization fixed-time artificial insemination program
Márcio de Oliveira Marques, Fábio Morotti, Camila Bizarro da Silva, Mario Ribeiro Júnior, Rubens C&am 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 15 367-371 (5 pages)
This study was conducted to evaluate the influence of category (heifers, primiparous or multiparous cows) on pregnancy rates in a large scale resynchronization ovulation program. Nelore heifers (n = 903), primiparous lactating cows (n = 338) and multiparous lactating cows (n = 1,223) were synchronized using a conventional protocol of estradiol/P4-based fixed-time artificial insemination (FTAI). Thirty days after ultrasonography, females who failed the first FTAI were resynchronized with the same... -
Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways
Hongyan Zhao, Wei Liu, Yi Wang, Nannan Dai, Jianhong Gu, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zong-Ping Liu 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 3호 7 297-306 (10 pages)
Exposure to cadmium (Cd) induces apoptosis in osteoblasts (OBs); however, little information is available regarding the specific mechanisms of Cd-induced primary rat OB apoptosis. In this study, Cd reduced cell viability, damaged cell membranes and induced apoptosis in OBs. We observed decreased mitochondrial transmembrane potentials, ultrastructure collapse, enhanced caspase-3 activity, and increased concentrations of cleaved PARP, cleaved caspase-9 and cleaved caspase-3 following Cd treatment.... -
Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers
Claudia Concha, María Daniella Carretta, Pablo Alarcón, Ivan Conejeros, Diego Gallardo, Alejandra Isabel H 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 7 217-224 (8 pages)
Reactive oxygen species (ROS) production is one of the main mechanisms used to kill microbes during innate immune response. D-lactic acid, which is augmented during acute ruminal acidosis, reduces platelet activating factor (PAF)-induced ROS production and L-selectin shedding in bovine neutrophils in vitro. This study was conducted to investigate whether acute ruminal acidosis induced by acute oligofructose overload in heifers interferes with ROS production and L-selectin shedding in blood... -
Effects of alprazolam on capture stress-related serum cortisol responses in Korean raccoon dogs (Nyctereutes procyonoides koreensis)
Sun-A Kim, So-Yeong Lee, Junpei Kimura, Nam-Shik Shin* 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 16 103-105 (3 pages)
The purpose of this study was to evaluate the effect of alprazolam on the stress that Korean raccoon dogs (Nyctereutes procyonoides koreensis) may experience while caught in a live trap by measuring their serum cortisol response. The animals were placed in a live trap with or without being pretreated with oral doses of alprazolam. In both groups, pre-trap blood samples were initially collected without anesthesia before the animals were positioned in the live trap; then post-trap blood samples... -
Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex
Ivana D. Stevanović*, Marina D. Jovanović, Ankica Jelenković, Miodrag Čolić, Ivana Stojanović, Mil 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 3 15-22 (8 pages)
The present experiments were done to determine the effectiveness of a non-specific nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on oxidative stress parameters induced by aluminium chloride (AlCl3) intrahippocampal injections in Wistar rats. Animals were sacrificed 3 h and 30 d after treatments, heads were immediately frozen in liquid nitrogen and forebrain cortices were removed. Crude mitochondrial fraction preparations of forebrain cortices were used for the... -
Microbial pathogens in ticks, rodents and a shrew in northern Gyeonggi-do near the DMZ, Korea
Joon-Seok Chae, Do-Hyeon Yu, Smriti Shringi, Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, In-Yong Lee, Janet Foley 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 3호 9 285-294 (10 pages)
A total of 1,618 ticks [420 individual (adults) and pooled (larvae and nymphs) samples], 369 rodents (Apodemus agrarius, Rattus norvegicus, Tscherskia triton, Mus musculus, and Myodes regulus), and 34 shrews (Crocidura lasiura) that were collected in northern Gyeonggi-do near the Demilitarized Zone (DMZ) of Korea during 2004-2005, were assayed by PCR for selected zoonotic pathogens. From a total of 420 individual and pooled tick DNA samples, Anaplasma (A.)phagocytophilum (16), A. platys (16),... -
Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry
Meejung Ahn, Heechul Kim, Jeong Tae Kim, Jeeyoung Lee, Jin Won Hyun, Jae Woo Park, Taekyun Shin 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 4호 1 309-314 (6 pages)
We studied the expression of caveolin-1 in the spinal cords of rats using 60Co γ-ray irradiation (single dose of 8 Gray (Gy)) in order to determine the possible involvement of caveolin-1 in the tissues of the central nervous system after irradiation. Spinal cords sampled at days 1, 4, and 9 post-irradiation (PI) (n = 5 per each time point) were analyzed by Western blot and immunohistochemistry. Western blot analysis showed that the expression of caveolin-1 was significantly increased at day 1... -
Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet
Beom Jun Lee, Jong-Koo Kang, Eun-Yong Jung, Young Won Yun, In-Jeoung Baek, Jung-Min Yon, Yoon-Bok Lee, Heon-Soo Sohn, Jae-Yong L 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 3호 7 227-234 (8 pages)
Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of male reproductive system. Five-week-old ICR mice were purchased and fed with a soybean-based Purina Chow diet until 6 months of age. The animals were exposed by gavage to genistein (2.5 mg/kg/day) or 17β-estradiol (7.5μg/kg/day) for five weeks. Corn oil was used for the negative control. The animals were fed the... -
The Antinociceptive and Anti-inflammatory Effect of Ethylacetate Extracts from Bang-Poong (Radix ledebouriellae) on the Freund’s Adjuvant-Induced Arthritis in Rats
Hyun-Woo Kim, Young-Bae Kwon, Tae-Won Ham, Dae-Hyun Roh, Seo-Yeon Yoon, Ho-Jae Han, Sung-Keel Kang, Hye-Jung Lee, Woung-Chon Mar 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 13 343-349 (7 pages)
In this study, we aimed to determine the antinociceptive and/or anti-inflammatory effect of Bang-Poong (BP, Radix Ledebouriellae) on Freund's adjuvant-induced arthritis in rats. Traditionally, BP has been used to treat several inflammatory diseases such as arthritis. Whole BP is extracted into two fractions that were ethylacetate and hexane-soluble fractions. Adult Sprague-Dawley rats (n=30, 130-150 g) were subcutaneously administered by the Freund's complete adjuvant (FCA) into the plantar... -
Topology of Scavenger Receptor Class B Type I (SR-BI) on Brush Border Membrane
Chang-Hoon Han and Mun-Han Lee 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 3 265-272 (8 pages)
Both hydropathy plot and in vitro translation results predict the topology of SR-BI; the receptor is an integral membrane protein of 509 amino acids, consisting of a short cytoplasmic N-terminus of 9 amino acids followed by a first transmembrane domain of 22 amino acids, the extracellular domain of 408 amino acids, the second transmembrane domain of 22 amino acids, and the cytoplasmic C-terminus of 47 amino acids. The immunoblot of rBBMV in the presence or absence of pAb589 peptide antigen (the... -
Expression of Recombinant Porcine Interleukin-2 and Application of Its Antibody to Immunoassays
In-Soo Choi and Han-Sang Yoo 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 3호 10 207-212 (6 pages)
Interleukin-2 plays an important role in T lymphocyte proliferation and immune response regulations. In this study, porcine IL-2 cDNA was cloned from peripheral blood mononuclear cells, and recombinant porcine IL-2 (rpIL-2) was expressed in Escherichia coli. The size of rpIL-2 without signal peptides was about 15 kDa when determined by SDS-PAGE and Western blotting analysis. Anti-rpIL-2 antibody was produced from mice immunized with the purified rpIL-2, and its specificity was examined by... -
Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis
Kwon Hur, Jung-Rae Kim, Byung-Il Yoon, Jung-Keun Lee, Jae-Hoon Choi, Goo-Taeg Oh, Dae-Yong Kim 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2000, 제 1권 제 2호 9 121-126 (6 pages)
Deregulation of G1 cyclins has been reported in several human and rodent tumors including colon cancer. To investigate the expression pattern of G1 cyclins in 1,2- dimethyl-hydrazine dihydrochloride (DMH)-induced rat colon carcinogenesis, we studied the expression of cyclin D1 and cyclin E by quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry (IHC). The mRNA level of cyclin D1 was increased 1.2-fold in adenocarcinomas but not significantly in... -
Prognostic factors and efficacy of human intravenous immunoglobulin G in dogs with idiopathic immune-mediated hemolytic anemia: a retrospective study
So-young Park , Hakhyun Kim , Byeong-taek Kang , Ji-houn Kang , Mhan-pyo Yang 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2016, 제 56권 제 3호 2 139-145 (7 pages)
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Effects of 5-HT4 selective receptor agonist, mosapride citrate on electrocardiogram in dogs
Ji Sang Chae , Jin Ok Ahn , Ye Rin Coh , Chong Woo Park , Hwa Young Youn 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 5 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 3호 3 163-167 (5 pages)
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EFFECTS OF SEVERAL CYTOKINES ON THE FUNCTIONS OF FETAL RAT OSTEOBLAST-LIKE CELLS IN VITRO
Hee-Sung Han, Jung-Keun Kim, Young-Il Chang 대한치과교정학회 The Korean Journal of Orthodontics 8 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 4 689-696 (8 pages)
Effects of several cytokines(IL -1β, TNFα, and IFNγ) have been examined on fetal rat osteoblast-like cells. To investigate whether cytokines play direct causal roles in production of lysosomal enzyme, fetal rat osteoblast-like cells were treated with IL-1β, TNFα, and IFNγ, respectively or combined. And acid phosphatase was determined by biochemical method. Alkaline phosphatase was assayed to determine the effects of IL-1β, TNFα, and IFNγ on the... -
Carbon monoxide releasing molecule-2 protects mice against acute kidney injury through inhibition of ER stress
Md Jamal Uddin, Eun Seon Pak, Hunjoo Ha 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 10 567-575 (9 pages)
Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for AKI is largely supportive, and endoplasmic reticulum (ER) stress has emerged as a novel mediator of AKI. Since carbon monoxide attenuates ER stress, the objective of the present study aimed to determine the protective effect of carbon monoxide releasing molecule-2 (CORM2) on AKI associated with ER... -
Functional identification of protein phosphatase 1-binding consensus residues in NBCe1-B
KyuPilLee, HyunJinKim, DongkiYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 10 91-99 (9 pages)
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B. Consequently, we focused on identifying the function of the PP1-binding consensus residue, 922FMDRLK927, in NBCe1-B. Using site-directed mutagenesis and co-immunoprecipitation assays, we revealed that in cases where the residues were substituted (F922A, R925A, and K927A) or... -
Epigenetic modification of α-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer
Ye-NaHa, HyeYounSung, San-DukYang, YunJuChae, WoongJu, Jung-HyuckAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 5 43-51 (9 pages)
Although cisplatin is one of the most effective antitumor drugs for ovarian cancer, the emergence of chemoresistance to cisplatin in over 80% of initially responsive patients is a major barrier to successful therapy. The precise mechanisms underlying the development of cisplatin resistance are not fully understood, but alteration of DNA methylation associated with aberrant gene silencing may play a role. To identify epigenetically regulated genes directly associated with ovarian cancer cisplatin... -
Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
HanSolKim, HongliangLi, HyeWonKim, SungEunShin, MiSeonSeo, JinRyeolAn, Kwon-SooHa, Eun-TaekHan, Seok-HoHong, Il-WhanChoi, GraceChoi, Dae-su 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 7 415-421 (7 pages)
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K+ (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC50 value and... -
Effect of subcutaneous treatment with human umbilical cord blood-derived multipotent stem cells on peripheral neuropathic pain in rats
MinJuLee, TaeGyoonYoon, MoonkyuKang, HyunJeongKim, KyungSunKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 2 153-160 (8 pages)
In this study, we aim to determine the in vivo effect of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) on neuropathic pain, using three, principal peripheral neuropathic pain models. Four weeks after hUCBMSC transplantation, we observed significant antinociceptive effect in hUCB-MSC– transplanted rats compared to that in the vehicle-treated control. Spinal cord cells positive for c-fos, CGRP, p-ERK, p-p 38, MMP-9 and MMP 2 were significantly decreased in only CCI... -
Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s
JuyeonKo, JongyunMyeong, DongkiYang, InsukSo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 16 133-140 (8 pages)
Conflicting evidence has been obtained regarding whether transient receptor potential cation channels (TRPC) are store-operated channels (SOCs) or receptor-operated channels (ROCs). Moreover, the Ca/Na permeability ratio differs depending on whether the current-voltage (I-V) curve has a doubly rectifying shape or inward rectifying shape. To investigate the calcium permeability of TRPC4 channels, we attached GCaMP6s to TRPC4 and simultaneously measured the current and calcium signals. A TRPC4...
