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전체 선택해제
총 284건 검색
본문검색 결과만 보기
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Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins
SeungHeeHa, HyoungKyuKim, NguyenThiTuyetAnh, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 16 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 8 531-546 (16 pages)
Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and genomic alterations in human chondrocytes during lipopolysaccharide (LPS)-induced inflammation to elucidate the underlying mechanisms and consequences of TLR-4 activation. Human chondrocytes were cultured with LPS for 12, 24,and 36 h to induce TLR-4 activation. The... -
A study of the involvement of Japanese early childhood teachers in Clean-up Time
Fuminori Nakatsubo, Junko Minowa, Kiyomi Akita, Fumiko Sunaga 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 17 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2009, Vol.3 No.1 4 69-85 (17 pages)
The purpose of this study is to examine actual individual situations involving Japanese early childhood teachers during Clean-up Time. In this study, we utilized the method of video analysis. This is a useful study method as it can examine the interaction between teachers and children in detail and allows in depth discussion using videos as cues for arriving at discourse. The research findings were as follows: (1) The teachers adopt strategies appropriate to the children’s different ages and... -
Pandemic Screen Time: An Analysis of Parenting Practices Connected with Children’s Use of Media in South Korea and the United States during the COVID-19 Pandemic
Amie Kim, Hyeon-Seon Jeong, Rebekah Willett, Ju Lim, Mi Yoon, Gwanghee Kim 경인교육대학교 교육연구원 교육논총 16 Pages
경인교육대학교 교육연구원 교육논총 2022, 제 42권 제 3호 6 81-96 (16 pages)
This article reports on a study investigating the experiences of family media practices during the pandemic. The article is based on questionnaires and semi-structured interviews with 39 parents in South Korea and the United States who have children aged between 4 and 11. The article employs a framework developed by Livingstone and Blum-Ross to consider different “genres for ‘digital parenting’” (2020: 11). The article argues that although children’s screen time increased dramatically,... -
Implementation of the submarine diving simulation in a distributed environment
Ha. Sol, Cha. Ju-Hwan, Roh. Myung-Il, Lee. Kyu-Yeul 대한조선학회 International journal of naval architecture and ocean engineering 17 Pages
대한조선학회 International journal of naval architecture and ocean engineering 2012, Vol.4 No.3 211-227 (17 pages)
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Writing Strategies as Mediated Actions: A Case Study of L2 Research Paper Writing in an Electronic Environment
Choi Yeon Hee 이화여자대학교 교과교육연구소 교과교육학연구 17 Pages
이화여자대학교 교과교육연구소 교과교육학연구 2017, 제 21권 5호 1 471-487 (17 pages)
This study aims to analyze Korean EFL graduate students’ writing strategies as mediated actions in their semester- long process of L2 research paper writing using multiple resources including the Internet. Though the study was based on the sociocultural approach, it analyzed mediated writing strategies quantitatively and qualitatively. The participants’ writing processes were video-recorded; their use of the computer was recorded through a keystroke logging program; their writing strategies... -
Doing Inquiry like Scientists: Elementary Students’ Scientific Inquiry in an Untact Online Science Learning Environment
Jang Shinho 경인교육대학교 교육연구원 교육논총 13 Pages
경인교육대학교 교육연구원 교육논총 제 42권 특별호 7 79-91 (13 pages)
In this study, a scientific inquiry program was developed to allow elementary school students to practice self-directed inquiry, as scientists do, in untact online exploration. This study examined the main characteristics of student exploration that appeared in online scientific inquiry and investigated how students perceived it. For this study, 167 elementary school students from all over Korea participated in an untact online scientific inquiry program. The students explored a total of seven... -
Tibial dyschondroplasia is closely related to suppression of expression of hypoxia-inducible factors 1α, 2α, and 3α in chickens
Shucheng Huang, Mujeeb U. Rehman, Gang Qiu, Houqiang Luo, Muhammad K. Iqbal, Hui Zhang, Khalid Mehmood, Jiakui Li 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 14 107-115 (9 pages)
Tibial dyschondroplasia (TD) cases has not been reported in Tibetan chickens (TBCs), but it is commonly seen in commercial broilers characterized by lameness. The underlying mechanism remains unclear. Hypoxia-inducible factors (HIFs) are important regulators of cellular adaptation to hypoxic conditions. In this study, we investigated the role of HIF-1α, -2α, and -3α in hypoxia and thiram-induced TD and their effect on tibial growth plate development in Arbor Acres chickens (AACs) and TBCs.... -
Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers
Claudia Concha, María Daniella Carretta, Pablo Alarcón, Ivan Conejeros, Diego Gallardo, Alejandra Isabel H 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 7 217-224 (8 pages)
Reactive oxygen species (ROS) production is one of the main mechanisms used to kill microbes during innate immune response. D-lactic acid, which is augmented during acute ruminal acidosis, reduces platelet activating factor (PAF)-induced ROS production and L-selectin shedding in bovine neutrophils in vitro. This study was conducted to investigate whether acute ruminal acidosis induced by acute oligofructose overload in heifers interferes with ROS production and L-selectin shedding in blood... -
Analysis of antibiotic residues in milk from healthy dairy cows treated with bovine mastitis ointment using ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry
Eun-kee Park , Yong-jae Ryu , Chun-nam Cha , Chang-yeul Yoo , Suk Kim , Hu-jang Lee 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2016, 제 56권 제 4호 6 233-239 (7 pages)
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A quantitative modeling approach to estimate the risks posed by the smuggled animal products contaminated with Foot-and-Mouth Disease (FMD) virus
KiOkHong, GilHongLee, SonIlPak 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 9 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 2호 12 223-231 (9 pages)
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Non-Formal Arts Education - New Relational Structures to Facilitate Access to Resources
Janet Pillai 한국음악교육공학회 음악교육공학 9 Pages
한국음악교육공학회 음악교육공학 2004, 제 4호 7 125-133 (9 pages)
70년대 산업화의 도래 이래로, 말레이시아의 교육 체계는 예술에 대한 관심이 점점 감소하고 있음을 보여주고 있다. 음악, 춤, 드라마 또한 더 이상 초등학교 교과목에 포함되지 않는다. 예술은 교수-학습의 향상이나 경기 또는 학교 행사에 도움을 주기 위한 서비스 과목으로 취급될 뿐이다. 이 논문에서는 이와 같은 학교에서의 열악한 예술 교육 환경과 예술의 본질을 왜곡하는 예술 교육 형태에 대해 문제제기를 한다. 그리고 예술 교육이 예술의 본질에 접근하는 것이어야 함을 강조하며, 이에대한 대안으로 학교 밖과 지역... -
What Matters the Most for a Child's Development? Examining the relationships between Different parenting styles and the overall development of the children using Big-5-personality factors
SukMin Hong 한국교육치료학회 교육치료연구 12 Pages
한국교육치료학회 교육치료연구 2012, Vol.4 No.1 3 39-50 (12 pages)
The aim of the study was to see if it was the parents or the peers of the children that have the most impacts on the overall development of the children. Is it the parents that matters the most? Or is it the peers that matter the most to the overall development of the children? Children's the- Big-5 personality factors scores were examined in relation to the mothers and fathers Child Rearing Practices Questionnaires. Openness to new experiences and neuroticism only had noticeable significance,... -
4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts
Geum-HwaLee, Hyo-WonOh, Hyun-DaeLim, WanLee, Han-JungChae, Hyung-RyongKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 5 345-352 (8 pages)
High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were increased when the cells were exposed to high concentrations of glucose. We examined endoplasmic reticulum (ER) stress response because glucose metabolism is related to ER functional status. An ER stress response including the expression of glucose regulated protein 78... -
c-fos mRNA Expression in the Vestibular System following Hypergravity Stimulation in Rats
GuangShiJin, JaeHyoLee, JaeHeeLee, MoonYoungLee, MinSunKim, YuanZheJin, JeongHoonSong, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 1 1-7 (7 pages)
Altered environmental gravity, including both hypo- and hypergravity, may result in space adaptation syndrome. To explore the characteristics of this adaptive plasticity, the expression of immediate early gene c-fos mRNA in the vestibular related tissues following an exposure to hypergravity stimulus was determined in rats. The animals were subjected to a force of 2 g (twice earth's gravity) for 1, 3, or 12 h, and were examined poststimulus at 0, 2, 6, 12, and 24 h. RT-PCR (reverse transcription... -
PKA-Mediated Regulation of B/K Gene Transcription in PC12 Cells
Mi-HyunChoi, Ho-ShikKim, Sung-HoChoi, Mi-YoungKim, Yoon-SeongJang, Young-MinJang, Jeong-HwaLee, Seong-WhanJeong, In-KyungKim, Oh-JooKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.6 4 333-340 (8 pages)
B/K protein is a novel protein containing double C2-like domains. We examined the specific signaling pathway that regulates the transcription of B/K in PC12 cells. When the cells were treated with forskolin (50μM), B/K mRNA and protein levels were time-dependently decreased, reaching the lowest level at 3 or 4 hr, and thereafter returning to the control level. Chemicals such as dibutyryl-cAMP, cell- permeable cyclic AMP (cAMP) analogue and CGS21680, adenosine receptor A2A agonist, also... -
Effects of Interleukin-1β and Tumor Necrosis Factor-α on the Release of Collagenase and Gelatinase from Osteoblasts
Jong-GabEun, Dong-HeonBaek, Se-WonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 6 269-274 (6 pages)
A large number of factors such as osteotropic hormones, cytokines, or growth factors are related to the bone remodeling which is characterized by the coupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Recent investigations have indicated that cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) play a potential role in the bone resorption associated with a variety of pathological conditions such as inflammatory osteolytic disease.... -
Effects of Insulin and IGFS on Growth and Functional Differentiation in Primary Cultured Rabbit Kidney Proximal Tubule Cells -Growth and membrane transport-
Han, Ho-Jae, Park, Kwon-Moo, 대한생리학회 대한생리학회지 12 Pages
대한생리학회 대한생리학회지 1995, 제 29권 제 2호 1 191-202 (12 pages)
the culture environment. 4. The uptake of α-MG, Pi and Na was significantly increased in cells incubated with insulin or IGF-I, IGF-II had no effect on the uptake of these substrates. 5. Na-pump activity, as assayed by Rb uptake, was significantly increased in cells treated with insulin or IGFs. In conclusion, insulin and IGF-I exert stimulatory effects on growth and membrane transporter(glucose, Na, Pi, and Na-pump) activities in primary cultured rabbit kidney proximal tubule cells. IGF-II had... -
Voltage-Dependent Ionic Currents and Their Regulation by GTP and Phorbol Ester in the Unfertilized Eggs of Mouse and Hamster
Kim, Ik-Hyun, Kim, Yang-Mi, Haan, Jae-Hee, Park, Choon-Ok, Hong, Seong-Geun 대한생리학회 대한생리학회지 14 Pages
대한생리학회 대한생리학회지 1993, 제 27권 제 1호 9 93-106 (14 pages)
The present study was performed to investigate the properties of ionic currents elicited by voltage pulses in the unfertilized eggs of mouse and hamster by using the whole cell voltage clamp techniques and to find out if there are any differences in properties between eggs of the two rodents. In addition, the modulatory effect of G proteins and protein kinase C (PKC) on the ionic channels were observed. The inward current in hamster eggs was shown to be due to Ca2+ current (ica)). The current... -
Long-term Care in Norway: Organization, Provision and Recent Trends in Developing the Sector
Kristin Løkke 한국노년학연구회 한국노년학연구 11 Pages
한국노년학연구회 한국노년학연구 2010, 제 19권 1 3-13 (11 pages)
I will introduce you a brief overview of the health care system in Norway (population 4.9 millions; life expectancy at birth 82 years for women and 78 years for men) and I will give you an introduction to the organization and financing of the primary health care with main focus on long term care. I will point out the future challenge sin long term care in Norway. Last, but not least I will give you an introduction to how we plan and prepare for meeting the future challenges through what we... -
Melting Characteristics of Simulated Non-combustible Radioactive Wastes in a Plasma Torch Melter System
Seung-Chul Park, Hyun-Je Cho, Cheon-Woo Kim 한국열환경공학회 열환경공학 7 Pages
한국열환경공학회 열환경공학 2011, 제 8권 3호 7 53-59 (7 pages)
To reduce the volume of the low- and intermediate-level radioactive wastes and to improve the radionuclide confinement after disposal of the slag product, a 500kW-grade DC plasma torch melter system was developed by the KHNP-CRI(Korea Hydro & Nuclear Power Co., LTD Central Research Institute). Main equipment of the system consists of a dual mode plasma torch, a water cooling refractory melter, an waste feeder, a slag tapping equipment, etc. Especially, the high-technology of a dual mode... -
A STUDY OF TRANSCENDENCE OF YOUNG CHILDREN DURING PLAY UNDER TEACHER-CHILD RELATIONSHIP
Dr.Anyamanee Boonsue 환태평양유아교육연구학회 Pacific Early Childhood Education Research Association Annual Conference 17 Pages
환태평양유아교육연구학회 Pacific Early Childhood Education Research Association Annual Conference 14th 11 432-448 (17 pages)
by the subjects. The environment was in a school context involving both outdoor and indoor play using Gordon Wells’ Modes of Meaning as a research methodology. Another goal was to find out what kinds of play patterns lead children to transcend. Furthermore, this research includes the study of the performance indicators of the key informant teachers using Robert Kegan’s Subject-Object Interview (SOI) to find out how differences in the teachers’ orders of mind affected ways of transcendence in... -
Preschool Parents’ Ratings of Parent-teacher Relationships. A look at the Impact of Family Demographics
Keengwe Grace, Onchwari Ariri J. 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 27 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2022, Vol.16 No.2 12 247-273 (27 pages)
Relationships between families and teachers are important quality indicators of an effective early childhood program and a child’s development indicators. Assessment of these relationships provides program administrators and policy makers insights into the effectiveness of their programs in impacting children’s and family outcomes. In this study, using the newly developed FPTRQ Measure, parents’ perceptions of parent-teacher relationships in preschool programs were assessed. The effects of... -
What Knowledge and Skills Do Chinese Kindergarten Teachers Need in a Time of Reform: Director’s Perspectives
Xin Fan, Berenice Nyland, Chris Nyland 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 22 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2016, Vol.10 No.3 2 27-48 (22 pages)
This paper reports on a research program that investigates policy and practice relating to the building of a Chinese early childhood workforce in a context of changed government policy, improved standards regarding teacher qualifications and curriculum content, and changing parental expectations. The evolving context reflects the fact that recent economic development in China has witnessed enhanced need for a workforce that is suitable for jobs that require advanced skills and a high capacity to... -
Children’s Understanding of Racial Diversity through Role-Play: A Case Study of Kindergarteners in South Korea
Su-Jeong Wee, So Jung Kim, Kyoung Jin Kim 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 25 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2016, Vol.10 No.2 7 125-149 (25 pages)
In spite of the emphases on multicultural education and role-playing activities in early childhood classrooms in South Korea, there has been a startling paucity of studies examining the effectiveness of role-play in teaching kindergarteners multiracial and ethnic awareness. This qualitative case study examines how South Korean kindergarteners develop their perception and understanding of racial and cultural diversity through role-plays. 25 five year-old children and their parents and teacher... -
Risk-Taking in the New Zealand Bush: Issues of Resilience and Wellbeing
Amanda Bateman, Jane Waters 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 23 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2018, Vol.12 No.2 2 7-29 (23 pages)
of the outdoor environment in a way that encourages risk-taking and builds resilience through problem solving. The collaborative achievement of the activities between the pre- school teacher and the fouryear- old children are discussed as an important and necessary aspect of the interactions, which we suggest may represent physical sustained shared thinking, for supporting wellbeing whilst building resilience and risk-taking. Implications for future practice are considered with regard to... -
A Cultural-Historical Reading of the Emotional Development of Young Children
Marilyn Fleer, Marie Hammer, Sue March 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 21 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2014, Vol.8 No.2 4 47-67 (21 pages)
The telling of fairytales has been a longstanding practice within the field of early childhood education in many communities across the Asia Pacific region. But what do we know about how educators use fairytales for the development of emotions for preschool aged children? In drawing upon culturalhistorical theory (Vygotsky, 1971, 1987, 1999), this paper presents the findings of a study into how fairytales were introduced to preschool aged children (n=30; from 3.3 to 5.3 years with mean age 4.2... -
International Collaborative Faculty Development Program on Simulation-Based Healthcare Education: A Report on Its Successes and Challenges
Hyun Soo Chung, S. Barry Issenberg, Paul Phrampus, Geoff Miller, Sang Mo Je, Tae Ho Lim, Young Min Kim 한국의학교육학회 Korean Journal of Medical Education 9 Pages
한국의학교육학회 Korean Journal of Medical Education 2012, 제 24권 제 4호 6 319-327 (9 pages)
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Comparative Analysis of Defense Responses in Chocolate Spot-Resistant and -Susceptible Faba Bean (Vicia faba) Cultivars Following Infection by the Necrotrophic Fungus Botrytis fabae
한국식물병리학회 The Plant Pathology Journal 12 Pages
한국식물병리학회 The Plant Pathology Journal 2014, 30권 4호 3 355-366 (12 pages)
In this study, resistance responses were investigated during the interaction of Botrytis fabae with two faba bean cultivars expressing different levels of resistance against this pathogen, Nubaria (resistant) and Giza 40 (susceptible). Disease severity was assessed on leaves using a rating scale from 1 to 9. Accumulation levels of reactive oxygen species (ROS), lipid peroxidation and antioxidant enzymes (superoxide dismutase, catalase and ascorbate peroxidase) were measured in leaf tissues at... -
Introduction and Re-writing of Aristotle’s De Anima by Early Jesuits in China
Vincent Shen 서강대학교 철학연구소 철학논집 44 Pages
서강대학교 철학연구소 철학논집 2009, 제 17집 2 51-94 (44 pages)
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Students’ attitudes toward online learning during the pandemic era -focusing on practice courses at a university of education
Lee Yun-Jung 경인교육대학교 교육연구원 The Journal of Education 18 Pages
경인교육대학교 교육연구원 The Journal of Education 2020, Vol.3 No.2 4 59-76 (18 pages)
Through a survey conducted among 64 students at a Gyeongin university of education during the COVID-19 pandemic, this research explores students’ attitude toward online learning, compares them with previous research outcomes, invites student suggestions for better learning, and analyzes their responses to find any intrinsic structure of learning performance. In a similar way to previous research, this study produces the pros (strength) and cons (weakness) of online education as follows. First,... -
Inflammation affects the viability and plasticity of equine mesenchymal stem cells: possible implications in intra-articular treatments
Laura Barrachina, Ana Rosa Remacha, Antonio Romero, Francisco Jos? V?zquez, Jorge Albareda, Marta Prades, Beatriz Ranera, Pilar 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 6 39-49 (11 pages)
primed-eBM-MSCs was significantly impaired. Tri-lineage differentiation assay revealed that exposure to inflammatory synovial fluid did not alter eBM-MSCs differentiation potential; however, eBM-MSCs primed with cytokines did not display osteogenic, adipogenic or chondrogenic phenotype. The inflammatory synovial environment is well tolerated by eBM-MSCs, whereas cytokine priming negatively affects the viability and differentiation abilities of eBM-MSCs, which might limit their in vivo efficacy. -
Molecular analysis of hprt mutation in B6C3F1 mice exposed to ozone alone and combined treatment of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate for 32 and 52 weeks
Min Young Kim, Hyun Woo Kim, Jin Hong Park, Jun Sung Kim, Hwa Jin, Seo Hyun Moon, Kook Jong Eu, Hyun Sun Cho, Gami Kang, Yoon Sh 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 14 379-385 (7 pages)
Potential toxicological interactions of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and/or dibuthyl phthalate (DBP) on ozone were investigated after 32- and 52-wk exposures using hprt mutation assay. Male and female B6C3F1 mice exposed to ozone (0.5 ppm), NNK (1.0 mg/kg), DBP (5,000 ppm), and two or three combinations of these toxicants 6 h per day for 32- and 52-wk showed increases in the frequencies of TG rlymphocytes compared to the control groups. Additive interactions were... -
Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
Ran Hong, Song Iy Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 5 513-523 (11 pages)
an acidic environment altered the expression of atg5, HSPA1B, collagen XIII , collagen XXAI , slug, snail , and zeb1 genes which are related to regulation of cell resistance to cytotoxicity and malignancy, and as expected, resulted in increased resistance of cells to multiple chemotherapeutic drugs including etoposide, doxorubicin, daunorubicin, cisplatin, oxaliplatin and 5-FU. Interestingly, however, acidic environment dramatically sensitized GC cells to apoptosis induced by tumor necrosis... -
YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity
WonSeogChong, SunYoungKang, YoungJinKang, MinKyuPark, YoungSooLee, HyeJungKim, HanGeukSeo, JaeHeunLee, HyeSookYun-Choi, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 5 283-290 (8 pages)
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced cellular and tissue injuries. In the present study, we investigated the effects of YS 49 against oxidant [tert-butylhydroperoxide (TBH)]-induced injury using cultured sheep pulmonary artery endothelial cells (SPAECs). The viability of SPAECs was determined by...
