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전체 선택해제
총 294건 검색
본문검색 결과만 보기
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Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress
Mi Na Lee, Sang Hun Lee, Min Young Lee, Yun Hee Kim, Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Yu Jin Lee, Mi Ok Kim, Kwangsun 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 3호 4 247-256 (10 pages)
Oxidative stresses induced by reactive oxygen species (ROS) have been shown to be involved in several physiological and pathophysiological processes, such as cell proliferation and differentiation. Steroid hormones can protect cells against apoptosis or induce cell proliferation by several mechanisms. Among androgenic hormones, dihydrotestosterone (DHT) is generated by a 5a- reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol, therefore DHT is considered a pure... -
Regulation of Vacuolar H+-ATPase c Gene Expression by Oxidative Stress
Whan-JongKwak, Seong-MookKim, Min-SungKim, Jung-HoonKang, Dong-JinKim, Ho-ShikKim, Oh-JooKown, In-KyungKim, Seong-WhanJeong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2005, Vol.9 No.5 4 275-282 (8 pages)
was lost in mutants of the GC box. We confirmed by electrophoretic mobility shift and supershift assays that Sp1 protein specifically binds to the GC box. The promoter activity was not changed by the H2O2 treatment and incubation in hypoxic chamber, however, H2O2 increased the stability of ATP6L mRNA. These data suggest that the expression of the ATP6L gene by oxidative stresses is regulated at posttranscriptional level, whereas the GC box is important in basal activities of the promoter. -
Effect of Bacillus mesonae H20-5 Treatment on Rhizospheric Bacterial Community of Tomato Plants under Salinity Stress
Shin Ae Lee, Hyeon Su Kim, Mee Kyung Sang, Jaekyeong Song, Hang-Yeon Weon 한국식물병리학회 The Plant Pathology Journal 10 Pages
한국식물병리학회 The Plant Pathology Journal 2021, 37권 6호 15 662-671 (10 pages)
Plant growth-promoting bacteria improve plant growth under abiotic stress conditions. However, their effects on microbial succession in the rhizosphere are poorly understood. In this study, the inoculants of Bacillus mesonae strain H20-5 were administered to tomato plants grown in soils with different salinity levels (EC of 2, 4, and 6 dS/m). The bacterial communities in the bulk and rhizosphere soils were examined 14 days after H20-5 treatment using Illumina MiSeq sequencing of the bacterial... -
Survival Factor Gene FgSvf1 Is Required for Normal Growth and Stress Resistance in Fusarium graminearum
Taiying Li, Boknam Jung, Sook-Young Park, Jungkwan Lee 한국식물병리학회 The Plant Pathology Journal 13 Pages
한국식물병리학회 The Plant Pathology Journal 2019, 35권 5호 1 393-405 (13 pages)
is required for the diauxic growth shift and survival under stress conditions. In this study, we characterized the role of FgSvf1, the Svf1 homolog in the homothallic ascomycete fungus Fusarium graminearum. In the FgSvf1 deletion mutant, conidial germination was delayed, vegetative growth was reduced, and pathogenicity was completely abolished. Although the FgSvf1 deletion mutant produced perithecia, the normal maturation of ascospore was dismissed in deletion mutant. The FgSvf1 deletion mutant... -
The Roles of Two hfq Genes in the Virulence and Stress Resistance of Burkholderia glumae
Jieun Kim, Mohamed Mannaa, Namgyu Kim, Chaeyeong Lee, Juyun Kim, Jungwook Park, Hyun-Hee Lee, Young-Su Seo 한국식물병리학회 The Plant Pathology Journal 14 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 5호 7 412-425 (14 pages)
B. glumae in rice plants. Other biochemical characteristics such as siderophore production and sensitivity to H2O2 induced oxidative stress were also found to be regulated by the hfq1 gene. However, lipase activity was shown to be unassociated with both tested genes. To the best of our knowledge, this is the first study to elucidate the functions of two hfq genes in B. glumae. Identification of virulence-related factors in B. glumae will facilitate the development of efficient control measures. -
Association of Grit and Body Composition with Fatigue and Burnout among Shift-work Nurses
Baek MinJung, Han Kihye 한국기초간호학회 Journal of Korean Biological Nursing Science 9 Pages
한국기초간호학회 Journal of Korean Biological Nursing Science 2022, Volume 24, No 3 1 141-149 (9 pages)
aimed to investigate the effects of grit and body composition on fatigue and burnout in shift-working nurses. Methods: A descriptive cross-sectional design using self-report questionnaires was employed. Data were collected between February and April 2021 from 192 shift-working nurses in 22 units of C tertiary hospitals. Of the 192, 175 nurses returned their completed questionnaires (return rate: 91.1%). The participants objectively measured their body composition for three consecutive days using... -
Effects of Cognition, Daily-living Stress, and Health-promotion Behavior on Subjective Memory Complaints by Community-dwelling Elders
Hwang Eun Hee, Kim Kon Hee 한국노인간호학회 노인간호학회지 9 Pages
한국노인간호학회 노인간호학회지 2019, 제 21권 제 3호 1 135-143 (9 pages)
a structured questionnaire composed of SMC, cognition, daily-living stress (DS), and health-promotion behavior (HB). Data were analyzed using the SPSS 25.0 program for descriptive statistics, Pearson correlations, and multiple regression. Results: The average age of participants was 73.7±6.71 years, and SMC was 5.82±2.87. SMC was significantly different according to education (F=8.33, p<.001), presence of a spouse (t=4.99, p<.001); economic status (F=10.10, p<.001); type of living arrangements... -
The effects of an additional weight aquatic exercise program on balance and lower extremity strength in persons with stroke
Jae-ho Park, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2018, 제 7권 제 1호 2 6-12 (7 pages)
Objective: The purpose of this study was to investigate the effects of an additional weight aquatic exercise program on the balance and lower extremity strength on aquatic environment in persons with stroke. Design: Randomized controlled trial. Methods: All subjects were randomly divided into three groups where thirteen subjects were in the additional weight aquatic exercise group, twelve subjects in the aquatic exercise group, and fifteen subjects in the control group. Subjects received a... -
The immediate effects of patellar taping on balance and gait ability in individuals with chronic stroke
Jin Shin, Mee-Hyang Mun, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 9 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 2호 8 125-133 (9 pages)
Objective: The aim of this study is to investigate the effect of patellar taping on balance and gait abilities in chronic stroke patients. Design: Randomized placebo-controlled trial. Methods: Thirty chronic stroke patients who have been diagnosed at least six months or before were recruited from R hospital. These study subjects were randomized to the experimental group (n=15) or placebo group (n=15). In the experimental group, patellar taping was applied while for the placebo group, placebo... -
Molecular mechanism of aging process in various aging models
Hae Young Chung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 13 95-95 (1 pages)
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Integrated analysis of microRNA and mRNA expressions in peripheral blood leukocytes of Warmblood horses before and after exercise
Hang-Ah Kim, Myung-Chul Kim, Na-Yon Kim, Doug-Young Ryu, Hong-Seok Lee, Yongbaek Kim 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 13 99-106 (8 pages)
Exercise capacity is a valuable trait in horses, and it has been used as a horse selection criterion. Although exercise affects molecular homeostasis and adaptation in horses, the mechanisms underlying these effects are not fully described. This study was carried out to identify changes in the blood profiles of microRNAs (miRNAs) and mRNAs induced by exercise in horse leukocytes. Total RNAs isolated from the peripheral blood leukocytes of four Warmblood horses before and after exercise were... -
Evaluation of the ureteral jet in dogs by using color Doppler ultrasonography
Hyunjung Oh, Seongsoo Kim, Suyeon Kim, Jeosoon Lee, Sookyung Yun, Junghee Yoon, Joohyun Jung, Mincheol Choi 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 17 399-406 (8 pages)
Ureteral jets are the result of a forceful ejection of urine from the vesicoureteral junction into the urinary bladder. By using color Doppler ultrasonography (US), we aimed to identify distinct ureteral jets in dogs, provide insight into ureteral obstruction, and facilitate study of urodynamics and vesicoureteric sphincter function via pulsed Doppler US. Color Doppler US was applied to detect urinary flow from the right ureteral orifices in eight healthy beagles. Under anesthesia, 0.9% saline... -
Calcium homeostasis in diabetes mellitus
Changhwan Ahn, Ji-Houn Kang, Eui-Bae Jeung 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 3호 1 261-266 (6 pages)
Diabetes mellitus (DM) is becoming a lifestyle-related pandemic disease. Diabetic patients frequently develop electrolyte disorders, especially diabetic ketoacidosis or nonketotic hyperglycemic hyperosmolar syndrome. Such patients show characteristic potassium, magnesium, phosphate, and calcium depletion. In this review, we discuss a homeostatic mechanism that links calcium and DM. We also provide a synthesis of the evidence in favor or against this linking mechanism by presenting recent... -
Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
Ihsan Ali, Syed Zahid Ali Shah, Yi Jin, Zhong-Shu Li, Obaid Ullah, Nan-Zhu Fang 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 1 1-9 (9 pages)
for protein folding, modification, and cellular homeostasis. ER stress is activated by a variety of factors including ROS. Such stress leads to activation of the adaptive unfolded protein response (UPR), which restores homeostasis. However, chronic stress can exceed the toleration level of the ER, resulting in cellular apoptosis. In this review, we briefly describe the generation and impact of ROS in preimplantation embryo development, the ROS-mediated activation mechanism of the UPR via the ER,... -
The current epidemiological status of infectious coryza and efficacy of PoulShot Coryza in specific pathogen-free chickens
Moo-Sung Han, Jong-Nyeo Kim, Eun-Ok Jeon, Hae-Rim Lee, Bon-Sang Koo, Kyeong-Cheol Min, Seung-Baek Lee, Yeon-Ji Bae, Jong-Suk Mo, 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 3호 8 323-330 (8 pages)
Infectious coryza (IC) is an infectious disease caused by Avibacterium (Av.) paragallinarum. IC is known to cause economic losses in the poultry industry via decreased egg production in layers. Between 2012 and 2013, Av. paragallinarum was isolated from seven chicken farms by Chungbuk National University. We identified Av. paragallinarum, the causative pathogen of IC by polymerase chain reaction (PCR) and serovar serotype A, by multiplex PCR. Antibiotic sensitivity tests indicated that a few... -
Laparoscopic ovariectomy in dogs: comparison between laparoendoscopic single-site and three-portal access
Angelo E. Tapia-Araya, Idoia D?az-G?emes Martin-Portugu?s, Laura Fresno Bermejo, Francisco Miguel S?nchez-Margallo 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 4호 17 525-530 (6 pages)
This study was conducted to evaluate the feasibility and therapeutic safety of laparoendoscopic single-site ovariectomy (LESS-OVE) and 3-portal laparoscopic ovariectomy (Lap-OVE) in dogs. Ten female mixed breed dogs were included in the study. Dogs were divided into group 1 (LESS-OVE; n = 5) and group 2 (Lap-OVE; n = 5). All procedures were performed by laparoscopic-skilled surgeons, and the anesthetic protocol was the same for all patients. In both groups, the ovarian vascular pedicle and... -
β-irradiation (Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin
Joong-Sun Kim, Kyung-Jin Rhim, Won-Seok Jang, Sun-Joo Lee, Yeonghoon Son, Seung-Sook Lee, Sunhoo Park, Sang Moo Lim 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 1 1-9 (9 pages)
In the present study, the detrimental effect of β-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of β-emission delivered by Ho patches. Clinicopathological and immunohistochemical changes in exposed skin were monitored for 18 weeks after β-irradiation. Radiation induced desquamation at 2∼4 weeks and gradual repair of this damage was evident 6 weeks after irradiation. Changes in basal cell density... -
Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1
Woochul Chang, Chang Youn Lee, Jun-Hee Park, Moon-Seo Park, Lee-So Maeng, Chee Soon Yoon, Min Young Lee, Ki-Chul Hwang*, Yong-An 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 1호 10 69-76 (8 pages)
The use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. The expression of microRNA-210 (miR-210) is induced by hypoxia and is important for cell survival under hypoxic conditions. Hypoxia increases the levels of hypoxia inducible factor-1 (HIF-1) protein and miR-210 in human MSCs (hMSCs). miR-210 positively regulates HIF-1a activity.... -
Low dietary inorganic phosphate affects the lung growth of developing mice
Cheng-Xiong Xu, Hua Jin, Youn-Sun Chung, Ji-Young Shin, Soon-Kyung Hwang, Jung-Taek Kwon, Sung-Jin Park, Eun-Sun Lee, Arash Mina 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 2호 3 105-113 (9 pages)
Inorganic phosphate (Pi) plays a critical role in diverse cellular functions, and regulating the Pi balance is accomplished by sodium-dependent Pi co-transporter (NPT). Pulmonary NPT has recently been identified in mammalian lungs. However, to date, many of the studies that have involved Pi have mainly focused on its effect on bone and kidney. Therefore, current study was performed to discover the potential effects of low Pi on the lung of developing transgenic mice expressing the... -
Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice
Amira M. K. Abouelella, Yasser E. Shahein*, Sameh S. Tawfik, Ahmed M. Zahran 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2007, 제 8권 제 4호 5 341-352 (12 pages)
Echinacea (E.) purpurea herb is commonly known as the purple coneflower, red sunflower and rudbeckia. In this paper, we report the curative efficacy of an Echinacea extract in ■-irradiated mice. E. purpurea was given to male mice that were divided into five groups (control, treated, irradiated, treated before irradiation & treated after irradiation) at a dose of 30 mg/kg body weight for 2 weeks before and after irradiation with 3 Gy of ■-rays. The results reflected the detrimental... -
Excitability scores of goats administered ascorbic acid and transported during hot-dry conditions
J. O. Ayo, N. S. Minka, M. Mamman1 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 2호 6 127-131 (5 pages)
and highly significant (p < 0.001), in both experimental and control goats. Our results indicate that road transportation induces considerable stress (depression) in goats as evidenced by a lower excitability score posttransportation. Moreover, the administration of AA pretransportation facilitated the transition from a state of depression to excitation. In conclusion, AA administration to animals prior to transportation may ameliorate the depression often encountered after road transportation. -
B6C3F1 mice exposed to ozone with 4-(N-methyl-Nnitrosamino)-1-(3-pyridyl)-1-butanone and/or dibutyl phthalate showed toxicities through alterations of NF-κB, AP-1, Nrf2, and osteopontin
Min Young Kim, Kyung Suk Song, Gun Ho Park, Seung Hee Chang, Hyun Woo Kim, Jin Hong Park, Hwa Jin, Kook Jong Eu, Hyun Sun Cho, G 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 2호 7 131-137 (7 pages)
of B6C3F1 mice. Electrophoretic mobility shift assay (EMSA) indicated that mice treated with combination of toxicants induced high NF-kB activities. Expression levels of p105, p65, and p50 proteins increased in all treated mice, whereas IkB activity was inhibited in NNK-, DBP-, and combination-treated ones. All treated mice except ozone-treated one showed high AP-1 binding activities. Expression levels of c-fos, c-jun, junB, jun D, Nrf2, and OPN proteins increased in all treated mice. Additive... -
Application of pulsed Doppler ultrasound for the evaluation of small intestinal motility in dogs
Yong-joo An, Heechun Lee, Dongwoo Chang, Youngwon Lee, Jai-ki Sung, Mincheol Choi, Junghee Yoon 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2001, 제 2권 제 1호 12 71-74 (4 pages)
The purpose of this study was to verify whether small intestinal peristalsis could be observed and quantitatively assessed using pulsed-Doppler ultrasound. Pulsed-Doppler ultrasound was used to evaluate small intestinal peristalsis after a meal in ten normal dogs and ten sedated dogs. The small intestinal peristalses were measured 0, 1, 3, 6, 9, 12, and 24 hours after a 24-hour fast and after feeding. The number of small intestinal peristalsis were 0.133/min, 0.100/min, 0.033/min, 0.167/min,... -
Dietary zinc inhibits the formation of colonic preneoplastic lesion induced by azoxymethane and dextran sodium sulfate in mice
Hyun Ji Park , Dang Young Kim , Bong Su Kang , Ja Seon Yoon , Jae Hwang Sang Yoon Nam , Young Won Yun , Jong Soo Kim , B 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 10 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2012, 제 52권 제 2호 8 115-124 (10 pages)
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Protective effect of ethyl acetate extract of Ishige okamurae against carbon tetrachloride-induced acute liver injury in rats
So Hi Kang , Won Jun Yang , Han Seul Oh , Yeon Ji Bae , Mee Jung Ahn , Min Chul Kang , Ryeo Kyeong Ko , Gi Ok Kim , Jun 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 7 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2011, 제 51권 제 4호 2 259-265 (7 pages)
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The development of an arts curriculum: some personal reflections.
Madonna Stinson 한국음악교육공학회 음악교육공학 9 Pages
한국음악교육공학회 음악교육공학 2004, 제 4호 6 115-123 (9 pages)
이 연구에서는 오스트레일리아 퀸스랜드의 예술교과 요목 개발 과정에 대해 설명하고 있다. 교육과정 개발 프로젝트는 1998년부터 2001년까지 4년에 걸쳐 이루어졌다. 그 결과 각각의 예술 요소에 대한 연구를 위한 기준을 포함하는 교사 지원 자료들의 범위와 모든 교사들을 위한 CD-Rom의 개발 뿐만 아니라 교과 요목의 개발이 이루어졌다. 이 논문에서는 퀸스랜드에서 채택된 협의적 교육과정(consultative curriculum)의 개발 과정에 대한 몇 가지 의견들을 제안한다. 또한 연구자는 싱가폴의 학교에서 연극에 대한 관심이 증가하는... -
그래미 음악교육가상이 미국 음악교육에 미친 영향
한국음악교육학회 음악교육연구 2020, 제 49권 제 4호 10 231-250 (20 pages)
본 연구는 미국 ‘그래미 음악교육가상’이 미국 음악교육의 사회적 인식 변화와 발전에 미친 영향을 탐구 하는데 목적이 있다. 미국 교육가상의 특징을 살펴보기 위해 미국 주요 교육가상의 종류, 선발기준, 선발방법 등을 조사하고, 그래미 음악교육가상의 제정 과정, 선정 참여 주체, 선정 방법 등을 조사하였다. 연구결과 미국 그래미 음악교육가상은 미국 그래미상의 사회적, 문화적, 경제적 영향력에 힘입어 미국 사회에 음악교육의 중요성과 음악교사의 가치를 널리 알리는데 주요한 역할을 했으며, 미국 음악 교육가들과 함께... -
마음챙김의 심리적 단계와 인성교육
한국교육치료학회 교육치료연구 2015, Vol.7 No.3 4 393-413 (21 pages)
한다. 한편 인성교육은 부정적 감정과 행동을 치유하고 예방하는 협의의 인성교 육과, 긍정적 감정과 행동도 계발하고 도덕적 덕목까지를 포함하는 광의의 인성교육으로 구분될 수 있다. 이 양자는 마음챙김의 심리과정과 직·간접으로 연계된다. 특히 뇌영상과 심리척도 결과에 의 하면, 마음챙김기반 스트레스감소(Mindfulness-Based Stress Reduction: MBSR) 프로그램의 명상훈련은 뇌 신경 구조와 기능에 영향을 주어, 주의, 감정, 관점은 물론 행동까지 변화시키고 있다. 따라서 마음 챙김 명상훈련은 의도확립, 주의 조절, 감정... -
Patterns of Psychosocial Adaptation to Chronic Illness and Disability
Jeong Han Kim, Norman L. Berven Yves, Ambroise Summer, Ibarra Tae Sun Kim 한국교육치료학회 교육치료연구 22 Pages
한국교육치료학회 교육치료연구 2010, Vol.2 No.2 1 1-22 (22 pages)
This study examined the patterns of psychosocial adaptation to chronic illness and disability(CID), defined in terms of subjective well-being and coping strategies in a sample of 100 individuals with various CID conditions. Cluster analysis revealed four distinct clusters of respondents, suggesting a varying degree of psychosocial adaptation. These clusters were labeled succumbing(n=9), surviving(n=40), resilient(n=41), and thriving(n=10). Our findings indicate that resilient and succumbing... -
Inhibitory effects of 2,6-di-tert-butyl-4-hydroxymethylphenol on asthmatic responses to ovalbumin challenge in conscious guinea pigs
Seul-YongJeong, Ji-YunLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 9 81-89 (9 pages)
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical... -
Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing’s syndrome
MinaKim, Hae-AhmLee, Hyun-MinCho, Seol-HeeKang, EunjoLee, InKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.1 3 23-33 (11 pages)
Cushing’s syndrome (CS) is a collection of symptoms caused by prolonged exposure to excess cortisol. Chronically elevated glucocorticoid (GC) levels contribute to hepatic steatosis. We hypothesized that histone deacetylase inhibitors (HDACi) could attenuate hepatic steatosis through glucocorticoid receptor (GR) acetylation in experimental CS. To induce CS, we administered adrenocorticotropic hormone (ACTH; 40 ng/kg/day) to Sprague-Dawley rats by subcutaneous infusion with osmotic mini-pumps. We... -
Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
Jun-WonHeo, Mi-HyunNo, Dong-HoPark, Ju-HeeKang, DaeYunSeo, JinHan, P.DarrellNeufer, Hyo-BumKwak 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.6 1 567-577 (11 pages)
in oxidative stress) in skeletal muscle. The balance between mitochondrial fusion and fission is critical to maintain mitochondrial homeostasis in skeletal muscle. Obesity impairs mitochondrial dynamics, leading to an unbalance between fusion and fission by favorably shifting fission or reducing fusion proteins. Mitophagy is the catabolic process of damaged or unnecessary mitochondria.Obesity reduces mitochondrial biogenesis in skeletal muscle and increases accumulation of dysfunctional cellular... -
Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation
GyoungWanLee, JaeHyoKim, MinSunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 8 423-428 (6 pages)
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer’s collateral commissural fibers were... -
Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries
RanyVorn, HaeYoungYoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 11 91-97 (7 pages)
Hyperglycemia is associated with an increased risk of cardiovascular diseases. It has been demonstrated that chronic exposure to high glucose impaired endothelial functions. However, specific effects of short-term exposure to high glucose on vascular reactivity are controversial. Moreover, the combined effects of other metabolic substrates such as free fatty acids (FFA) on vascular reactivity remain poorly understood. Here we investigate the effects of short-term exposure to high glucose with or...
