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허혈성 뇌졸중 유발 백서에서 수중운동이 하지근 및 대뇌의 HSP 70 발현에 미치는 영향
김기도, 김은정, 천진성, 김경윤, 김계엽, 유영대, Kim. Gi-Do, Kim. Eun-Jung, Chun. Jin-Sung, Kim. Kyoung-Yoon, Kim. Gye-Yeop, Yoo. Young-Dae 한국전문물리치료학회 한국전문물리치료학회지 10 Pages
한국전문물리치료학회 한국전문물리치료학회지 2006, Vol.13 No.3 57-66 (10 pages)
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수온별 Red Sea Bream Iridovirus (RSIV) 인위감염에 따른 돌돔의 누적폐사 및 Heat Shock Protein (HSP) 70의 동정
김석렬, 정병문, 정성주, 키타무라 신이치, 김두운, 김도형, 오명주, Kim. Seok-Ryel, Jeong. Byeong-Mun, Jung. Sung-Ju, Kitamura. Shin-Ichi, Kim. Du-woon, Kim. Do-Hyung, O 한국어병학회 韓國魚病學會誌= Journal of fish pathology 8 Pages
한국어병학회 韓國魚病學會誌= Journal of fish pathology 2008, Vol.21 No.1 13-20 (8 pages)
RSIV의 수온에 따른 병원성을 규명하기 위한 연구의 일환으로 수온별로 RSIV를 인위적으로 감염시킨 돌돔의 누적폐사를 관찰하고, 다른 온도에서 사육된 돌돔의 온도 스트레스 단백질인 HSP이 관여하는지를 확인하고자, 돌돔의 HSP 유전자의 염기서열 일부를 밝혔다. 각온도별 감염실험에서 17°C와 20°C의 경우 폐사가 발생하지 않았으나, 25°C 및 27°C 수조에서는 각각 90%와 80%의 누적 폐사율을 보였다. 돌돔에서 확인된 HSP 유전자의 일부는 넙치에서 확인된 HSP70와 97%의 homology를 나타내 돌돔의 HSP70으로 판단되었다. -
흑마늘 투여와 운동이 고강도 운동 후 TBARS, HSP 70 및 COX-2 발현에 미치는 영향
백영호, 이상호, 한민호, 최영현, 김승현, 곽이섭, Baek. Yeong-Ho, Lee. Sang-Ho, Han. Min-Ho, Choi. Yung-Hyun, Kim. Seung-Hyun, Kwak. Yi-Sub 한국생명과학회 생명과학회지 6 Pages
한국생명과학회 생명과학회지 2012, Vol.22 No.6 772-777 (6 pages)
총 4주간 트레드밀로 실시하였으며, 시료 채취 하기 바로 직전에 고강도 운동을 실시하였다. 흑마늘 섭취는 흑마늘진액을 구강 투여시켰으며, 연구결과 다음과 같다. 4주간의 흑마늘 투여와 유산소운동 후 고강도 운동을 실시하였을 때 TBARS 농도는 흑마늘운동군이 흑마늘군, 운동군과 대조군에 비해 유의하게 낮았다. 흑마늘군과 운동군은 대조군에 비해 유의하게 낮았다. HSP 70 발현은 흑마늘섭취군이 다른군에 비해 상대적으로 낮게 나타났다. COX-2 발현은 모든군에서 비슷한 발현을 보이고 있으며 규칙적인 운동과 흑마늘 섭취는... -
벼 엽록체 small HSP의 과발현에 의한 형질전환 식물체의 내열성 증가
원성혜, 조진기, 이병헌 한국생명과학회 생명과학회지 7 Pages
한국생명과학회 생명과학회지 2003, Vol.13 No.1 83-89 (7 pages)
HSP의 기능을 조사하기 위하여 벼로부터 분리한 엽록체 small HSP를 구성적으로 발현하는 형질전환 식물체를 제작하였다. 먼저 고온 스트레스 조건하에서의 형질전환 식물체의 내열성을 chlorophyll 형광으로 측정하여 분석하였다. Leaf disc를 고온 스트레스 조건에서 5분간 처리한 후, 광화학계 II의 불활성화를 나타내는 Fo 값과 증가치를 조사하였다. 형질전환 식물체는 고온 스트레스 하에서의 Fo 값의 증가가 현저하게 감소하였다. 또한 무균적으로 Petri dish에서 재배한 유식물체를 치사온도인 $52^{circ}C$에서 45분간 처리한... -
Expression of Cu/Zn SOD Protein Is Suppressed in hsp 70.1 Knockout Mice
Choi. S-Mi, Park. Kyung-Ae, Lee. Hee-Joo, Park. Myoung-Sook, Lee. Joung-Hee, Park. Kyoung-Chan, Kim. Man-Ho, Lee. Seung-Hoon, Seo. Jeong 생화학분자생물학회 Journal of biochemistry and molecular biology 4 Pages
생화학분자생물학회 Journal of biochemistry and molecular biology 2005, Vol.38 No.1 111-114 (4 pages)
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Protection of Metal Stress in Saccharomyces cerevisiae: Cadmium Tolerance Requies the Presence if Two ATP-Binding Domains of Hsp 104 Protein
이경희, 엄정훈, Lee. Gyeong Hui, Eom. Jeong Hun 대한화학회 Bulletin of the Korean Chemical Society 5 Pages
대한화학회 Bulletin of the Korean Chemical Society 2001, Vol.22 No.5 514-518 (5 pages)
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A study on the patterns of expression of the DAZ and HSP genes in the testicular tissue of men with azoospermia
Lee. Ho-Joon, Lee. Hyoung-Song, Song. Gyun-Jee, Byun. Hye-Kyung, Cho. Youl-Hee, Kim. Jong-Hyun, Seo. Ju-Tae, Lee. Yoo-Sik 대한의학유전학회 Journal of genetic medicine 6 Pages
대한의학유전학회 Journal of genetic medicine 1997, Vol.1 No.1 51-56 (6 pages)
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단백뇨를 동반한 IgA 신병증 및 HSP 신염을 가진 소아에서 메틸프레드니솔론 충격요법과 경구 스테로이드 요법의 비교
안지영, 문정은, 황영주, 최봉석, 고철우, 조민현, Ahn. Ji Young, Moon. Jung Eun, Hwang. Young Ju, Choi. Bong Seok, Ko. Cheol Woo, Cho. Min Hyun 대한소아신장학회 대한소아신장학회지 5 Pages
대한소아신장학회 대한소아신장학회지 2014, Vol.18 No.1 24-28 (5 pages)
7명(IgA 신병증 5명, HSP 신염 2명; Group 1)에 대해서는 2개월 간격으로 모두 3회의 메틸프레드니솔론 충격요법이 시행되었으며 나머지 14명(IgA 신병 증 10명, HSP 신염 4명; Group 2)에 대해서는 경구 스테로이드요법이 시행되었다. 결과: Group 1의 평균 진단 당시 연령과 조직검사 당시 연령은 Group 2에 비해 어린 경향을 보였으나 통계적인 차이는 없었다. 내원 당시 두 군의 모든 환자는 혈뇨를 동반하였으며 Group 1의 5명(71.4%)과 Group 2의 14명 (100%)은 단백뇨를 동반하였다. 수축기 평균 혈압은 두 군간에 유의한 차이가... -
신증후군을 동반한 HSP 신염에서 Azathioprine의 치료 효과
손진태, 김지홍, 김병길, 정현주, Son. Jin-Tae, Kim. Ji-Hong, Kim. Pyung-Kil, Chung. Hyeun-Joo 대한소아신장학회 대한소아신장학회지 9 Pages
대한소아신장학회 대한소아신장학회지 1998, Vol.2 No.1 41-49 (9 pages)
효과적인 치료 방법에 대해서는 알려져 있지 않다. 이에 저자들은 신증후군을 동반한 HSP신염에서의 azathioprine(AZA)의 치료 효과를 살펴보고자 본 연구를 시작 하였다. 방법 : 신증을 동반한 HSP 신염으로 진단 받은 15명을 대상으로 prednisolone과 AZA를 8개월간 투여하여 치료 효과를 관찰하였다. AZA는 초기용량으로 2 mg/kg/day을 매일 2회 분복하였으며, 같은 기간동안 prednisolone을 0.5-1.0 mg/kg씩 격일로 투여하였다. 치료 전후에 신조직검사를 시행하여 조직 변화를 관찰하였고 AZA의 부작용의 여부를 관찰하였다. 결과 :... -
비소세포폐암에서 Survivin, HSP 및 Bcl-2 발현에 관한 면역조직화학적 분석
홍현주, 홍석균, 이계영, 김우호, 이춘택, 유철규, 한성구, 심영수, 김영환, Hong. Hyun-Ju, Hong. Seok-Gyun, Lee. Kye-Young, Kim. Woo-Ho, Lee. Choon-Taek, Yoo. Chul-Gyu, Han. 대한결핵및호흡기학회 결핵 및 호흡기 질환 12 Pages
대한결핵및호흡기학회 결핵 및 호흡기 질환 2002, Vol.52 No.5 441-452 (12 pages)
단백질이고 최근에 survivin이라 하는 IAP군과 HSP 등이 새롭게 밝혀졌고 이들은 많은 암종에서 발견되었다. 이에 저자들은 비소세포폐암을 대상으로 survivin, HSP70, 그리고 bcl-2의 발현에 대해서 면역조직화학적 분석을 시행함으로써 임상적 특성과의 관련성을 알아보고자 하였다. 방 법 : 99예의 비소세포폐암 조직으로 변역조직화학적 염색을 시행하였으며 일차 항체로 anti-survivin rabbit polyclonal antibody, anti-HSP70 mouse monoclonal antibody, anti-Bcl-2 mouse monoclonal antibody를 이용하였다. 각각의 단백질 발현과... -
벼 Small HSP의 발현에 의한 대장균의 고온 stress 하에서의 내성의 증가
이벙현, 이효신, 원성혜, 조진기, Lee. Byung-Hyun, Lee. Hyo-Shin, Won. Sung-Hye, Jo. Jin-Ki 경북대학교 농업생명과학대학 慶北大農學誌 5 Pages
경북대학교 농업생명과학대학 慶北大農學誌 1999, Vol.17 No.4 59-63 (5 pages)
벼의 엽록체 small HSP의 고온 스트레스 하에서의 기능을 밝히기 위하여 Oshsp21 cDNA를 pET 발현 vector에 도입하였다. 형질전환된 대장균 배양액에 IPTG를 첨가하여 단백질 발현을 유도시킨 다음 고온 stress 하에서의 생존율을 대조구와 비교하였다. 그 결과 대조균주의 경우 $50^{circ}C$에서의 생존율이 크게 감소하였으나 Oshsp21이 발현된 대장균의 경우 70% 이상의 생존율을 나타내었다. 또한 대장균 단백질을 $55^{circ}C$에서 30분간 열처리한 후, 대장균 단백질을 가용성과 비가용성 단백질로 분획한 다음, 각각의 비율을... -
소아와 성인 $Henoch-Sch"{o}nlein$ Purpura(HSP) 신염의 임상적 비교
김기은, 신윤호, 신재일, 박지민, 정현주, 이재승, Kim. Ki-Eun, Shin. Youn-Ho, Shin. Jae-Il, Park. Jee-Min, Jeong. Hyeon-Joo, Lee. Jae-Seung 대한소아신장학회 대한소아신장학회지 9 Pages
대한소아신장학회 대한소아신장학회지 2003, Vol.7 No.2 157-165 (9 pages)
여러 장기를 침범하는 전신성 혈관염으로 신장손상이 예후를 좌우하는 중요한 원인이 된다. 성인 HSP 신염은 빈도가 낮고 임상 경과에 대한 연구가 부족한 편이다. 소아와 성인 HSP 신염의 임상 및 경과를 전반적으로 비교함으로서 각각의 예후에 영향을 주는 인자를 알아보고자 하였다. 방법 : 1986년 1월부터 2003년 5월까지 17년 4개월간 연세대학교 세브란스병원에 내원한 15세 미만의 소아 81명과 15세 이상의 성인 25례를 대상으로 후향적으로 고찰하였다. 결과 : 남녀비는 소아 1.5:1, 성인 1.3:1이었고, 발병 계절은 두 군 모두... -
지구성 운동이 STZ-당뇨 유발 쥐의 허혈/재 관류 손상 후 심근의 당대사 관련 표현형 단백질과 HSP-60 단백질 발현에 미치는 영향
배희숙, 엄현섭, 강은범, 양춘열, 이용로, 이창국, 천우호, 전혜자, 조인호, 조준용, Bae. Hee-Suk, Um. Hyun-Seob, Kang. Eun-Bum, Yang. Chum-Yeol, Lee. Yong-Ro, Lee. Chang-Guk, Che 한국생명과학회 생명과학회지 8 Pages
한국생명과학회 생명과학회지 2009, Vol.19 No.5 644-651 (8 pages)
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Antimicrobial Resistance and Virulence Profiles of Enterococcus spp. isolated from Horses in Korea
Dae Ho Kim, Yeon Soo Chung, Jae Won Song, Sook Shin, Young Kyung Park, Soo Jin Yang, Suk Kyung Lim, Kun Taek Park, Yong Ho Park 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 63 357-357 (1 pages)
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Angiogenic Effects of Spheroid Formation from Mesenchymal Stem Cells
Mi Jeong Park, Jeong Su Byeon, Na Yeon Gu, Jienny Lee, In Soo Cho, Sang Ho Cha 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 321 367-368 (2 pages)
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Effects of Vegetable Peptide on Stem Cell Proliferation
Jienny Lee, Jeong Su Byeon, Mi Jeong Park, Na Yeon Gu, In Soo Cho, Sang Ho Cha 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 317 364-365 (2 pages)
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Identification of determinants that mediate binding between Tembusu virus and the cellular receptor heat shock protein A9
Dongmin Zhao, Qingtao Liu, Xinmei Huang, Huili Wang, Kaikai Han, Jing Yang, Keran Bi, Yuzhuo Liu, Lijiao Zhang, Yin Li 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 8 528-535 (8 pages)
Heat shock protein A9 (HSPA9), a member of the heat shock protein family, is a putative receptor for Tembusu virus (TMUV). By using Western blot and co-immunoprecipitation assays, E protein domains I and II were identified as the functional domains that facilitate HSPA9 binding. Twenty-five overlapping peptides covering domain I and domain II sequences were synthesized and analyzed by using an HSPA9 binding assay. Two peptides showed the capability of binding to HSPA9. Dot blot assay of... -
Chicken RNA-binding protein T-cell internal antigen-1 contributes to stress granule formation in chicken cells and tissues
Yingjie Sun, Pin Zhang, Hang Zheng, Luna Dong, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Chunchun Meng, Shengqing Yu, Chan 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 2 3-12 (10 pages)
T-cell internal antigen-1 (TIA-1) has roles in regulating alternative pre-mRNA splicing, mRNA translation, and stress granule (SG) formation in human cells. As an evolutionarily conserved response to environmental stress, SGs have been reported in various species. However, SG formation in chicken cells and the role of chicken TIA-1 (cTIA-1) in SG assembly has not been elucidated. In the present study, we cloned cTIA-1 and showed that it facilitates the assembly of canonical SGs in both human and... -
Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro
Xiao-Hui Zhang, Hong Wu, Shu Tang, Qiao-Ning Li, Jiao Xu, Miao Zhang, Ya-Nan Su, Bin Yin, Qi-Ling Zhao, Nicole Kemper, Joerg Har 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 2호 2 129-140 (12 pages)
(Akt), the signal transducer and activator of transcription (STAT)-3 and p-IKKα/β and the colocalization of Akt and STAT-3 with Hsp90 during heat stress, which was accompanied by improved viability and low apoptosis. GA significantly inhibited Akt expression and p-IKKα/β level, but not STAT-3 quantity, while the colocalization of Akt and STAT-3 with Hsp90 was weakened, followed by lower cell viability and higher apoptosis. Aspirin after GA treatment partially improved the stress response and... -
The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells
Xiao-hui Zhang, Huai-sen Zhu, Zhuang Qian, Shu Tang, Di Wu, Nicole Kemper, Joerg Hartung, En-dong Bao 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 1호 5 35-44 (10 pages)
of Hsp90 protein and hsp90 mRNA expression in chicken heart tissues after oral administration of aspirin following exposure to high temperature for varying times. Heat stress induced increases in plasma aspartate aminotransferase, creatine kinase and lactate dehydrogenase activities while causing severe heart damage, which was characterized by granular and vacuolar degeneration, nuclear shrinkage and even myocardium fragmentation in cardiac muscle fibers. After aspirin administration, myocardial... -
Proteomic analysis of chicken peripheral blood mononuclear cells after infection by Newcastle disease virus
Xiaoyu Deng, Yanlong Cong, Renfu Yin, Guilian Yang, Chan Ding, Shengqing Yu, Xiufan Liu, Chunfeng Wang, †, Zhuang Ding, 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 4호 7 511-517 (7 pages)
Characteristic clinical manifestations of Newcastle disease include leukopenia and immunosuppression. Peripheral blood mononuclear cells (PBMCs) are the main targets of Newcastle disease virus (NDV) infection. To survey changes in proteomic expression in chicken PBMCs following NDV infection, PBMC proteins from 30 chickens were separated using two- dimensional electrophoresis (2-DE) and subjected to mass spectrometry analysis. Quantitative intensity analysis showed that the expression of 78... -
Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos
Jongki Cho, Sungkeun Kang, Byeong Chun Lee* 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 2호 8 225-231 (7 pages)
of three specific genes (DNMT1, Hsp 70.1, and Mash2) related to early embryo development in transgenic SCNT embryos was compared between transgenic and non-transgenic SCNTs, parthenogenetic embryos, and in vitro fertilization (IVF) embryos. Transgenic SCNT embryos showed significantly lower rates of development to the blastocyst stage than non-transgenic ones. To investigate normal gene expression, RNA was extracted from ten blastocysts derived from parthenogenesis, IVF, non-transgenic, and... -
A simplified one-step nuclear transfer procedure alters the gene expression patterns and developmental potential of cloned porcine embryos
Sang Kyu Park, Sangho Roh*, Jong-Im Park* 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2014, 제 15권 제 1호 8 73-80 (8 pages)
developmentally important genes (OCT4, NANOG, EOMES, CDX2, GLUT-1, PolyA, and HSP70) were analyzed by real-time quantitative polymerase chain reaction. Both the developmental rate according to blastocyst stage as well as the expression levels CDX2, EOMES, and HSP70 were elevated with SONT compared to CTNT. The genes with elevated expression are known to influence trophectoderm formation and heat stress-induced arrest. These results showed that our SONT technique improved the development of SCNT... -
Hsp70 and HSF-1 expression is altered in the tissues of pigs transported for various periods of times
Miao Zhang, Zhenhua Yue, Zhijun Liu, Ali Islam, Buriro Rehana, Shu Tang, Endong Bao*, Jorg Hartung 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 3호 6 253-259 (7 pages)
The aim of this study was to assess changes of Hsp70 and HSF-1 protein and mRNA expression in stress-sensitive organs of pigs during transportation for various periods of time. Twenty pigs were randomly divided into four groups (0 h, 1 h, 2 h, and 4 h of transportation). A significant increased activity of AST and CK was observed after 1 h and 2 h of transportation. Histopathological changes in the heart, liver, and stomach indicated that these organs sustained different degrees of injury. Hsp70... -
Alpha basic crystallin expression in canine mammary tumors
Tolga Guvenc*, Mustafa Yavuz Gulbahar, Murat Yarim, Yonca Betil Kabak, Onder Karayigit, Mahmut Sozmen 대한수의학회 Journal of Veterinary Science 4 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 6 39-42 (4 pages)
The aim of this study was to evaluate prognostic and/or diagnostic factors of canine mammary tumors by immunohistochemically analyzing the expression of alpha basic crystallin (aB-c). For this, formalin-fixed, paraffin-embedded blocks of 51 naturally-occurring canine mammary tumors (11 benign and 40 malignant) were used. Tissue from eight normal canine mammary glands were served as a control. Immunohistochemically, in the control mammary tissues, a few luminal epithelial cells were aB-c positive... -
The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs
Mustafa Yavuz Gulbahar*, Yonca Betil Kabak, Mehmet Onder Karayigit, Murat Yarim, Tolga Guvenc, Unal Parlak 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 10 65-73 (9 pages)
HSP70) and alpha-basic-crystallin (α-BC) and their association with apoptosis and some related adaptor proteins in the pathogenesis of foot-and-mouth disease virus (FMDV)-induced myocarditis in lambs. HSP70 was generally overexpressed in the myocardial tissues and inflammatory cells of FMDV-induced myocarditis with differential accumulation and localization in same hearts when compared to non-foot-and-mouth disease control hearts. α-BC immunolabeling showed coarse aggregations in the Z line of... -
Extracellular acidity enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via DR5 in gastric cancer cells
Ran Hong, Song Iy Han 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2018, Vol.22 No.5 5 513-523 (11 pages)
The tumor microenvironment greatly influences cancer cell characteristics, and acidic extracellular pH has been implicated as an essential factor in tumor malignancy and the induction of drug resistance. Here, we examined the characteristics of gastric carcinoma (GC) cells under conditions of extracellular acidity and attempted to identify a means of enhancing treatment efficacy. Acidic conditions caused several changes in GC cells adversely affecting chemotherapeutic treatment. Extracellular... -
Induction of Heat Shock Proteins and Antioxidant Enzymes in 2,3,7,8-TCDD-Induced Hepatotoxicity in Rats
Hyun-SookKim, So-YoungPark, Ki-YeolYoo, SeungKwanLee, Woon-WonJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 14 469-476 (8 pages)
affect the expression of heat shock proteins and antioxidant enzymes using the real-time polymerase chain reaction (PCR) in rat. 2,3,7,8-TCDD increased heat shock protein (Hsp27, Ձ-B-crystallin, Mortalin, Hsp105, and Hsp90s) and antioxidant enzymes (SOD-3, GST and catalase) expression after a 1 day exposure in livers of rats, whereas heat shock protein (Ձ-B-crystallin, Hsp90, and GRP78) and antioxidant enzymes (SOD-1, SOD-3, catalase, GST, and GPXs) expression decreased on day 2 and... -
Proteomic Analysis of Differentially Expressed Proteins in Bovine Endometrium with Endometritis
ChangyongChoe, Jeong-WonPark, Eun-SukKim, Sung-GyuLee, Sun-YoungPark, Jeong-SoonLee, Myung-JeCho, KeeRyeonKang, JaeheeHan, DawonKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.4 2 205-212 (8 pages)
(HSP) 27, peroxiredoxin-6, luteinizing hormone receptor isoform 1, collectin-43 precursor, deoxyribonuclease-I (DNase-I), and MHC class I heavy chain (MHC-Ih) were up-regulated. In contrast, transferrin, interleukin-2 precursor, hemoglobin Ղ subunit, and potassium channel tetramerisation domain- containing 11 (KCTD11) were down-regulated in comparison to normal endometrium. The proteomic results were validated by semiquantitative-PCR and immunoblot analysis. The mRNA levels of desmin,... -
Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice
HyunJeongKim, Ji-InJung, YoungkyungKim, Jae-SeonLee, YoungWookYoon, JunesunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 7 157-161 (5 pages)
stress. Hsp70.1, a member of the hsp70 family is known to play an important role in cytoprotection from stressful insults. However, the functional role of Hsp70 in motor function after spinal cord injury (SCI) is still unclear. To study the role of hsp70.1 in motor recovery following SCI, we assessed locomotor function in hsp70.1 knockout (KO) mice and their wild-type (WT) mice via the Basso, Beattie and Bresnahan (BBB) locomotor rating scale, before and after spinal hemisection at T13 level. We... -
Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1α
Young-SukCho, Kyung-HoonLee, Jong-WanPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.2 5 91-97 (7 pages)
Epidermal keratinocytes overgrow in response to ultraviolet-B (UVB), which may be associated with skin photoaging and cancer development. Recently, we found that HIF-1Ձ controls the keratinocyte cell cycle and thereby contributes to epidermal homeostasis. A further study demonstrated that HIF-1Ձ is down-regulated by UVB and that this process is involved in UVB-induced skin hyperplasia. Therefore, we hypothesized that the forced expression of HIF-1Ձ in keratinocytes would... -
Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor
Ok-ByungChoi, Joo-HoonPark, YeJinLee, Chang-KwonLee, Kyung-JongWon, JunghwanKim, HwanMyungLee, BokyungKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 6 107-114 (8 pages)
(Hsp) 27 was significantly inhibited by the olibanum extract. The effects of PDGF-BB-induced extracellular signal-regulated kinase1/2 was not altered by the olibanum extract. Treatment with olibanum extract inhibited PDGF-BB-stimulated sprout out growth of aortic rings. These results suggest that the water extract of olibanum inhibits PDGF-BB-stimulated migration and proliferation in RASMCs as well as sprout out growth, which may be mediated by the inhibition of the p38 MAPK and Hsp27 pathways. -
Roles of ERK and NF-κB in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells
Seung-HunKang, Ji-HyukLee, Kyung-HaChoi, Byung-YongRhim, KoanhoiKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 7 171-176 (6 pages)
in AoSMCs. HSP22-induced IL-8 release was inhibited by U0126, but not by SB202190. A mutation in the IL-8 promoter region at the binding site of NF-ՊB, but not AP-1 or C/EBP, impaired promoter activation in response to HSP22. Delivery of IՊB, but not dominant negative c-Jun, lowered HSP22-induced IL-8 release from AoSMCs. These results suggest that HSP22 induces IL-8 in VSMCs via ERK1/2, and that transcription factor NF-kB may be required for the HSP22-induced IL-8 up-regulation. -
Relaxation Effect of Synthetic Ceramide Analogues in Cat Esophageal Smooth Muscle Cells
DooWonLee, SunYoungPark, JungSuRyu, SungHyoKim, ChaeUkIm, SuHangChoi, SeEunLee, SungKwonKo, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 2 137-142 (6 pages)
Ceramide has emerged as a novel second messenger for intracellular signalling. It is produced from sphingomyelin and is involved in the control of cell differntiation, proliferation, and apoptosis. C2- ceramide, short chain ceramide, plays a role in mediating contraction of cat esophageal smooth muscle cells. We examined the effect of synthesized ceramide analogues on the C2-ceramide and ACh-induced contraction in esophageal smooth muscle cells isolated with collagenase. CY3523, CY3525, or... -
Sweating by Exercise Controls Body Temperature through Increase of Interleukin-1beta
Jun-SangBae, Young-OhShin, Jeong-BeomLee, HyunSeok, Young-KiMin, Hun-MoYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.5 2 231-234 (4 pages)
This study was designed to investigate the expression and production of interleukin-1beta (IL-1β) in human peripheral blood of trained runners and untrained controls after temporary moderate intensity exercise. Male long-distance trained runners (TR) and untrained sedentary control subjects (SED) ran for 1 h at 70% of heart rate reserve (HRR). IL-1β gene and protein expressions were significantly higher in TR than those with SED at all 3 intervals examined independently. Significant increases... -
Cytotoxicological Effect of Tebufenozide, an Insect Growth Regulator (IGR): Stimulation of Filamentous Actin Reorganization and Enhancement of Hsp27 Expression in Drosophila Kc Cells
JeeNaHwang, Hwa-JinJung, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 4 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 10 351-354 (4 pages)
including aggregation and elongation of the cells. In order to understand the cellular mechanism underlying the response of Drosophila cells to tebufenozide, immunofluorescence microscopy was performed. We found that treatment of Kc cells with tebufenozide enhanced the reorganization of f-actin and stimulated the expression of hsp27. These data suggest a possible association of filamentous actin (f-actin) and hsp27 in the cytotoxicological mechanisms of growth regulators in Drosophila cells. -
Hyperthermia-induced Apoptosis is Independent upon DNA Strand Breaks in Human Lymphoid Cells
HwaJinJung, WonHyeKa, JeeNaHwang, YoungRokSeo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.6 9 345-350 (6 pages)
Heat shock (43oC for 60 minutes) is sufficient to induce apoptosis in a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human lymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a... -
Upregulation of Heat Shock Proteins in the Kidney in Hypertension
GeonLee, YoonWhaOh, JongUnLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.3 5 147-152 (6 pages)
the expression of HSP70, HSP32 and HSP25 was increased in the clipped kidney at both weeks 1 and 4. However, in the contralateral kidney, their expression was not significantly altered at week 1, but increased at week 4. In DOCA-salt hypertension, the expression of HSP remained unaltered in the remnant kidney at week 1, but significantly increased at week 4. These results indicate that HSP are differentially regulated in the kidney according to the duration and the model of hypertension. -
Cooperation of Gβ and Gαq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)
UyDongSohnTaiSangLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 9 349-355 (7 pages)
We previously shown that LES contraction depends on M3 receptors linked to PTX insensitive Gq protein and activation of PLC. This results in production of IP3, which mediates calcium release, and contraction through a CaM dependent pathway. In the esophagus ACh activates M2 receptors linked to PTX sensitive Gi3 protein, resulting in activation of PLD, presumably, production of DAG. We investigated the role of PLC isozymes which can be activated by Gq or Gβ protein on ACh-induced contraction in... -
Pulse Exposure to Ethanol Augments Vascular Contractility Through Stress Response
Eun-KyoungYangInKyeomKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 7 47-53 (7 pages)
contractility. After end of exposure to 1, 2.5 and 5% ethanol for 45 min, rat aortic strips were subjected to contractile responses, immunoblot for Hsp70 and the measurement of levels of myosin light chain phosphorylation. Exposure to 5% ethanol not only augmented contractions to KCl or phenylephrine, but also increased expression of Hsp70 and the levels of myosin light chain phosphorylation. There were no significant differences in contractions produced by 1μmol/L phorbol 12,13-dibutyrate, a... -
Effect of Heat Shock Protein 72 on the Generation of Reperfusion Arrhythmias
MoonJunChang, HeungSikNa, HyunJungNam, KyungSikPyun, SeungKilHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.4 7 319-324 (6 pages)
assessed whether HSP-producing substances, amphetamine and ketamine, afforded protection against reperfusion-induced ventricular fibrillation (VF) and these protective effect remained after the inhibition of HSP72 production by quercetin, a mitochondrial ATPase inhibitor. Adult mongreal male cats (n=60, 2.5∼4 kg) were used in this study. Experimental animals were divided into five groups; control group (n=15), amphetamine ('A', n=11) group, ketamine ('K', n=9) group, amphetamine-ketamine ('AK',... -
Hypothermic Preconditioning Lowers the Incidence of Hypothermic Arrest in Neonatal Rat
SungSookPark, HeungSikNa, HyunJungNam, SeungKilHong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 14 231-236 (6 pages)
This study was performed to examine 1) Whether hypothermic cardiac arrest produces myocardial HSP72 expression; 2) And if, whether it serves to protect the heart against the subsequent hypothermic arrest. In the present study, neonatal rats were placed in an icebath to induce hypothermia. To determine whether hypothermic cardiac arrest produces myocardial HSP72, experimental animals were subjected to 10-min hypothermic insult before the extraction of the heart. The intervals between the insult... -
고양이 허파에서 산소재유엽 손상을 결정하는 저산소증의 정도
남현정, 김유경, 나흥식, 홍승길 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 19 775-781 (7 pages)
136 -705， Korea A1though reoxygenation is the best way to salvage hypoxic tissues， reduced oxygen species (ROS) generated during reoxygenation are known to cause further tissue injuries and the induction of heat shock proteins (HSPs). The present study was undertaken to determine any causal relatiOI빼ip between t址severity of hypoxia and the opposite outcomes， either beneficial or detrimental， of the subsequent reoxygenation by measuring the HSP72. To this aim， one group (6 male cats， 2.5
