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전체 선택해제
총 143건 검색
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Postischemic Treatment with Aminoguanidine Inhibits Peroxynitrite Production in the Peroxynitrite Production in the Rat Hippocampus Following Transient Forebrain Ischemia
Yun-SikChoi, Yeo-HongYoon, JuEunLee, Kyung-OkCho, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 1 1-5 (5 pages)
a marker of peroxynitrite production. Posttreatment of aminoguanidine (200 mg/kg) significantly attenuated the neuronal death in the hippocampal CA1 area 3 days, but not 7 days, after ischemia-reperfusion. 3-Nitrotyrosine immunoreactivity was enhanced in the hippocampal CA1 area 3 days after reperfusion, which was prevented by the treatment of aminoguanidine (100 mg/kg and 200 mg/kg). Our findings showed that (1) the generation of peroxynitrite in the hippocampal CA1 area 3 days after... -
Increase of Peroxynitrite Production in the Rat Brain Following Transient Forebrain Ischemia
HeeJoonKimSeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.3 2 205-212 (8 pages)
enhanced during reperfusion, the cytotoxic oxidant peroxynitrite could be formed, but it is not known if this occurs following global forebrain ischemia-reperfusion. We examined whether peroxynitrite generation is increased in the vulnerable regions after forebrain ischemia- reperfusion. Transient forebrain ischemia was produced in the conscious rat by four-vessel occlusion. Rats were subjected to 10 or 15 min of forebrain ischemia. Immunohistochemical method was used to detect 3-nitrotyrosine,... -
염생식물 갯질경이의 Peroxynitrite 소거 활성
이정임, 공창숙, 정명은, 홍주완, 노일, 서영완, Lee. Jung-Im, Kong. Chang-Suk, Jung. Myoung-Eun, Hong. Joo-Wan, Noh. Il, Seo. Young-Wan 한국해양연구원 Ocean and polar research 7 Pages
한국해양연구원 Ocean and polar research 2011, Vol.33 No.2 185-191 (7 pages)
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어수리 어린 잎으로부터 Peroxynitrite 소거활성을 나타내는 플라보노이드 성분의 분리 및 함량분석
박희준, 누그로호 아궁, 정보람, 원유화, 정연주, 김원배, 최재수, Park. Hee-Juhn, Nugroho. Agung, Jung. Bo-Ram, Won. Yu-Hwa, Jung. Youn-Ju, Kim. Won-Bae, Choi. Jae-Sue 한국자원식물학회 韓國資源植物學會誌 6 Pages
한국자원식물학회 韓國資源植物學會誌 2010, Vol.23 No.5 393-398 (6 pages)
식용으로 사용되는 산채의 일종인 어수리의 지상부로부터 peroxynitrite 소거활성을 나타내는 성분을 분리한 결과 플라보노이드 성분인 hyperoside와 astragalin이 분리되었다. 특히, 높은 활성을 보였던 hyperoside는 이 식물재료 중 함량도 높아 어수리 잎은 peroxynitrite 과잉생산시 유발될 수 있는 당뇨병, 비만, 고지혈증, 심장질환 등의 예방과 치료에 유익한 식품이라 할 수 있을 것이다. -
약용식물의 Peroxynitrite와 Hydroxyl radical 소거 활성
민오진, 김민석, 곽병희, 류동영, Min. Oh-Jin, Kim. Min-Suk, Kwak. Byung-Hee, Rhyu. Dong-Young 한국자원식물학회 韓國資源植物學會誌 6 Pages
한국자원식물학회 韓國資源植物學會誌 2008, Vol.21 No.4 254-259 (6 pages)
약용식물 9종의 물 추출물에 대한 항산화 효과를 탐색하기 위해 in vitro 조건에서 강력한 산화력과 독성을 갖는 $ONOO^-$와 ${cdot}$OH radical의 소거효과를 측정하였다. 그 결과, 감잎, 구기자, 꾸지뽕나무, 담쟁이덩굴, 마디풀, 비파나무, 으름덩굴, 참취 추출물은 10${mu}g/ml$ 농도에서 50% 이상의$ONOO^$ 소거효과를 나타냈다. 이러한 $ONOO^-$ 소거효과는 양성 대조물인 penicillamine(94.08${pm}$3.04)에 비해 낮았지만 비파나무 물 추출물(89.87${pm}$4.57)이 다른 시료에 비해 가장 강력한 $ONOO^-$ 소거효과를 나타냈다.... -
국화과 17종 식물 30% 에탄올 추출물의 페놀성 화합물 분석 및 Peroxynitrite 소거효과
김명회, 누그로호 아궁, 임상철, 문혜은, 최재수, 박희준, Kim. Myung-Hoe, Nugroho. Agung, Lim. Sang-Cheol, Moon. Hye-Eun, Choi. Jae-Sue, Park. Hee-Juhn 한국생약학회 생약학회지 6 Pages
한국생약학회 생약학회지 2011, Vol.42 No.2 149-154 (6 pages)
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한국 산채류 8종 추출물의 폴리페놀 함량분석 및 Peroxynitrite 소거효과
누그로호 아궁, 김명회, 이진하, 김종대, 이강노, 최재수, 유영민, 박희준, Nugroho. Agung, Kim. Myung-Hoe, Lee. Jin-Ha, Kim. Jong-Dai, Lee. Kang-Ro, Choi. Jae-Sue, Yoo. Yeon 한국생약학회 생약학회지 8 Pages
한국생약학회 생약학회지 2011, Vol.42 No.1 38-45 (8 pages)
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상추 7 품종의 Quinic Acid 유도체 분석 및 Peroxynitrite 소거효과
누그로호 아궁, 장석우, 김원배, 이강노, 최재수, 박희준, Nugroho. Agung, Jang. Suk-Woo, Kim. Won-Bae, Lee. Kang-Ro, Choi. Jae-Sue, Park. Hee-Juhn 한국생약학회 생약학회지 6 Pages
한국생약학회 생약학회지 2009, Vol.40 No.4 376-381 (6 pages)
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병풍쌈 추출물의 Caffeoylquinic Acid 성분 분석과 Peroxynitrite 소거효과
박희준, 누그로호 아궁, 이진하, 김종대, 김원배, 이강노, 최재수, Park. Hee-Juhn, Nugroho. Agung, Lee. Jin-Ha, Kim. Jong-Dae, Kim. Won-Bae, Lee. Kang-Ro, Choi. Jae-Sue 한국생약학회 생약학회지 5 Pages
한국생약학회 생약학회지 2009, Vol.40 No.4 365-369 (5 pages)
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High-Performance Liquid Chromatographic Quantification and Validation of Luteolin Glycosides from Sonchus brachyotus and Their Peroxynitrite-Scavenging Activity
Nugroho. Agung, Kim. Myung-Hoe, Lee. Chan-Mi, Choi. Jae-Sue, Lee. Sang-Hyun, Park. Hee-Juhn 한국생약학회 Natural product sciences 8 Pages
한국생약학회 Natural product sciences 2012, Vol.18 No.1 39-46 (8 pages)
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염생식물로부터 Peroxynitrite와 DPPH 라디칼 소거 활성 검색
서영완, 이희정, 김유아, 안종웅, 이범종, 문성기 한국생물공학회 한국생물공학회지 5 Pages
한국생물공학회 한국생물공학회지 2004, Vol.19 No.1 57-61 (5 pages)
(Aster spathulifolius), 범행초 (Tetragonia tetragonoides)의 MeOH 추출물과 CH$_2$Cl$_2$ 추출물에서 각각 peroxynitrite의 소거효과가 관찰되었다. 그 중에서도 해당화 MeOH 추출물의 DPPH 래디칼 소거효과는 100 $mu extrm{g}$/$mell$ (f.c.) 농도에서 87.51%로 나타났고, peroxynitrite 소거효과는 5 $mu extrm{g}$/$mell$ 농도에서 표품의 ONOO를 첨가했을 때 97.03%와 SIN-1을 첨가했을 때 98.48%로서 가장 강력한 항산화활성을 가지는 것으로 나타났다. 해당화의 peroxynitrite의 효과는 대조군으로 사용된 penicillamine보다도... -
4-Hydroxynonenal Induces Endothelial Cell Apoptosis via ROS and Peroxynitrite Generation
정상운, 이수복, 이지영, 호세인 모하메드 악바르, 김동환, 장정윤, 윤정현, 정해영, 김남득, Chung. Sang-Woon, Yee. Su-Bog, Lee. Ji-Young, Hossain. Mohammad Akbar, Kim. Dong-Hwan, Y 한국생명과학회 생명과학회지 8 Pages
한국생명과학회 생명과학회지 2011, Vol.21 No.7 961-968 (8 pages)
실험을 통해 확인이 되었다. 또한 이 사실을 단백질의 변화를 통하여 확인을 할 수가 있었다. HNE를 24시간 처리한 세포에서 poly(ADP-ribose) polymerase 단백질 분절이 매개되었고 Bax의 발현량이 증가하였다. 또한 세포내의 활성 산소종들을 발생시켰다. 이에 생성된 활성 산소종과 peroxynitrite가 세포사와 관련이 있는가를 밝히기 위하여 이들의 포식자들인 N-acetylcysteine과 penicillamine을 본 연구에서 사용하였다. 이들 포식자들에 의해 HNE에 의해 유도되는 세포사가 억제가 되었기에 산화적 활성화가 HNE에 의해 유도된... -
Peroxynitrite에 의한 사람 신경세포종 SH-SY5Y의 glutathione 감소와 apoptosis
김명선, 이강민, 박래길 한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 7 Pages
한국독성학회 Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 2000, Vol.16 No.2 133-139 (7 pages)
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Simultaneous analysis and peroxynitrite-scavenging activity of galloylated flavonoid glycosides and ellagic acid in Euphorbia supina
Nugroho. Agung, Rhim. Tae-Jin, Choi. Moo-Young, Choi. Jae Sue, Kim. Youn-Chul, Kim. Min-Sun, Park. Hee-Juhn 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 9 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2014, Vol.37 No.7 890-898 (9 pages)
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Isolation and Quantitative Analysis of Peroxynitrite Scavengers from Artemisia princeps var. orientalis
Nugroho. Agung, Lee. Kang-Ro, Alam. Md. Badrul, Choi. Jae-Sue, Park. Hee-Juhn 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2010, Vol.33 No.5 703-708 (6 pages)
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Adenosine and Purine Nucleosides Prevent the Disruption of Mitochondrial Transmembrane Potential by Peroxynitrite in Rat Primary Astrocytes
Choi. Ji-Woong, Yoo. Byung-Kwon, Ryu. Mi-Kyoung, Choi. Min-Sik, Park. Gyu-Hwan, Ko. Kwang-Ho 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2005, Vol.28 No.7 810-815 (6 pages)
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Comparison of Spectrophotometric, HPLC and Chemiluminescence Methods for 3-Nitrotyrosine and Peroxynitrite Interaction
Turan. Nilufer Nermin, Ark. Mustafa, Demiryurek. Abdullah Tuncay 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2005, Vol.28 No.3 358-363 (6 pages)
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PKC Downstream of PI3-Kinase Regulates Peroxynitrite Formation for Nrf2-Mediated GSTA2 Induction
Kim. Sang-Geon, Kim. Sun-Ok 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 6 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2004, Vol.27 No.7 757-762 (6 pages)
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Further Isolation of Antioxidative $(+)-1-Hydroxypinoresinol-1-O-{eta}-D-glucoside$ from the Rhizome of Salvia miltiorrhiza that Acts on Peroxynitrite, Total ROS and 1,1-Diphenyl-2-picrylhydrazyl Radical
Kang. Hye-Sook, Chung. Hae-Young, Byun. Dae-Seok, Choi. Jae-Sue 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 4 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2003, Vol.26 No.1 24-27 (4 pages)
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Further Isolation of Peroxynitrite and 1, 1-Diphenyl-2-picrylhy-drazyl Radical Scavenging Isorhamnetin 7-Ο-glucoside from the Leaves of Brassica juncea L.
Choi. Jae-Sue, Jung. Mee-Jung, Park. Hye-Jin, Chung. Hae-Young, Kang. Sam-Sik 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 3 Pages
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 2002, Vol.25 No.5 625-627 (3 pages)
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Alteration of discoidin domain receptor-2 expression: possible role in peroxynitrite-induced apoptosis in human cerebral vascular smooth muscle cells
Li. Lin, Yue. Zhiyong, Wan. Xiaojuan, Zhang. Guodong, Song. Shasha, Bai. Xiaohui, Jiao. Yulian, Ju. Yuanrong, Li. Jianfeng 대한독성유전단백체학회 Molecular & cellular toxicology 6 Pages
대한독성유전단백체학회 Molecular & cellular toxicology 2012, Vol.8 No.4 401-406 (6 pages)
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The effect of coenzyme Q10 on endothelial function in a young population
Jerrold Petrofsky, M. Laymona, H. Lee, E. Hernandez, D. Dequine, L. Thorsen, R. Lovell, J. Andrade 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2012, 제 1권 제 1호 2 6-12 (7 pages)
Objective: Coenzyme (CoQ10) is an enzymatic co factor used in normal cellular metabolism. Recent evidence shows that in people with heart disease it can reverse endothelial cell damage in the blood vessels. It is also a potent antioxidant. Design: One group pretest-posttest design. Methods: In the present study, endothelial function was evaluated using the response to occlusion and heat before and 2 weeks after administration of CoQ10, 300 mg/day. Thirty Eight subjects, who are physical therapy... -
Mitochondrial and DNA damage in bovine somatic cell nuclear transfer embryos
In-Sun Hwang, Hyo-Kyung Bae, Hee-Tae Cheong 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2013, 제 14권 제 3호 1 235-240 (6 pages)
The generation of reactive oxygen species (ROS) and subsequent mitochondrial and DNA damage in bovine somatic cell nuclear transfer (SCNT) embryos were examined. Bovine enucleated oocytes were electrofused with donor cells and then activated by a combination of Ca-ionophore and 6-dimethylaminopurine culture. The H2O2 and ·OH radical levels, mitochondrial morphology and membrane potential (ΔΨ), and DNA fragmentation of SCNT and in vitro fertilized (IVF) embryos at the zygote stage were... -
Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex
Ivana D. Stevanović*, Marina D. Jovanović, Ankica Jelenković, Miodrag Čolić, Ivana Stojanović, Mil 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 1호 3 15-22 (8 pages)
The present experiments were done to determine the effectiveness of a non-specific nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on oxidative stress parameters induced by aluminium chloride (AlCl3) intrahippocampal injections in Wistar rats. Animals were sacrificed 3 h and 30 d after treatments, heads were immediately frozen in liquid nitrogen and forebrain cortices were removed. Crude mitochondrial fraction preparations of forebrain cortices were used for the... -
Application of biotechnological tools for coccidia vaccine development
Wongi Min, Rami A. Dalloul, Hyun S. Lillehoj 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2004, 제 5권 제 4호 1 279-288 (10 pages)
Coccidiosis is a ubiquitous intestinal protozoan infection of poultry seriously impairing the growth and feed utilization of infected animals. Conventional disease control strategies have relied on prophylactic medication. Due to the continual emergence of drug resistant parasites in the field and increasing incidence of broiler condemnations due to coccidia, novel approaches are urgently needed to reduce economic losses. Understanding the basic biology of host-parasite interactions and... -
Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis
Seungjoon Kim, Changjong Moon, Myung Bok Wie, Hyungmin Kim, Naoyuki Tanuma, Yoh Matsumoto, Taekyun Shin 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2000, 제 1권 제 1호 2 11-17 (7 pages)
To elucidate the role of nitric oxide synthase (NOS) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), we analyzed the expression of constitutive neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS) in the spinal cords of rats with EAE. We further examined the structural interaction between apoptotic cells and spinal cord cells including neurons and astrocytes, which are potent cell types of nitric oxide (NO) production in the brain. Western blot analysis... -
Serum nitrotyrosine concentration in dogs with myxomatous mitral valve disease
Jun-seok Kim , Jun-seok Park , Hyung-jin Park , Kyoung-won Seo , Kun-ho Song 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 5 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2017, 제 57권 제 1호 3 17-21 (5 pages)
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지질 과산화에 대한 전통약용 식물의 항산화 효과
하대식, 김충희, 김곤섭, 김의경 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 10 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 3호 4 341-350 (10 pages)
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EFFECTS OF SODIUM NITROPRUSSIDE ON THE FORMATION AND ACTIVATION OF THE OSTEOCLAST IN CULTURE
Young-Jae Yoo, Jung-Kun Kim, Kyung-Suk Cha 대한치과교정학회 The Korean Journal of Orthodontics 10 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 6 705-714 (10 pages)
Due to the great deal of effort that has gone into the study of osteoclastic differentiation and activation over the last few decades, the mechanisms of these two events have been discovered gradually. Nitric oxide(NO-), which is produced from arginine by a nitric oxide synthase, opened up a new area of biological research. Recently, it has been reported that NO- is produced by osteoblasts stimulated by lipopolysaccharide and several other cytokines. In this study, the effect of sodium... -
한약을 결합한 감로수 절식요법이 여성의 체성분 변화에 미치는 영향: 증례보고
백선은, 박은지, 김혜원, 유정은 한방비만학회 대한한방비만학회지 7 Pages
한방비만학회 대한한방비만학회지 2018, 제 18권 제 2호 10 152-158 (7 pages)
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삼정환의 랫드를 이용한 90일 반복 경구투여 독성시험
김민지(Min-Jee Kim), 이명종(Myeong-Jong Lee), 김호준(Hojun Kim) 한방비만학회 대한한방비만학회지 14 Pages
한방비만학회 대한한방비만학회지 2018, 제 18권 제 1호 5 36-49 (14 pages)
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삼정환의 랫드를 이용한 단회 경구투여 독성시험
김민지(Min jee Kim), 이명종(Myeong jong Lee), 김호준(Ho jun Kim) 한방비만학회 대한한방비만학회지 5 Pages
한방비만학회 대한한방비만학회지 2017, 제 17권 제 2호 5 96-100 (5 pages)
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Antioxidant Effects of Pyrogallol in Neural Cells and Mice Brain
Jisub Moon, Heesun Gwak, Tae-Hee Lee, Eun Suk An, Yun-Bae Kim, Dongsun Park 한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 12 Pages
한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 2019, 제 9권 제 3호 2 113-124 (12 pages)
Polyphenols can easily react with reactive oxygen species (ROS) resulting in powerful antioxidant activity. Pyrogallol is a polyphenol found in a variety of fruits and vegetables. Therefore, plants containing pyrogallol can be used for their antioxidant, anti-bacterial, anti-fungal, anti-allergic, and anti-inflammatory properties. However, its effectiveness as an antioxidant is still a matter of debate because pyrogallol is also a superoxide anion generator and induces superoxide anion-mediated... -
Hydroquinone suppresses IFN-β expression by targeting AKT/IRF3 pathway
YongKim, HanGyungKim, SangYunHan, DeokJeong, WooSeokYang, Jung-IlKim, JiHyeKim, Young-SuYi, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 9 547-554 (8 pages)
Previous studies have demonstrated the role of hydroquinone (HQ), a hydroxylated benzene metabolite, in modulating various immune responses; however,its role in macrophage-mediated inflammatory responses is not fully understood. In this study, the role of HQ in inflammatory responses and the underlying molecular mechanism were explored in macrophages. HQ down-regulated the expression of interferon (IFN)-β mRNA in LPS-stimulated RAW264.7 cells without any cytotoxicity and suppressed interferon... -
Reactive oxygen species increase neuronal excitability via activation of nonspecific cation channel in rat medullary dorsal horn neurons
HaeInLee, ByungRimPark, SangWooChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 2 371-376 (6 pages)
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region. Recent studies indicate that reactive oxygen species (ROS) is involved in persistent pain, primarily through spinal mechanisms. In this study, we aimed to investigate the role of xanthine/xanthine oxidase (X/XO) system, a known generator of superoxide anion (O2·-), on... -
JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38
Young-SuYi, Mi-YeonKim, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.3 9 345-352 (8 pages)
Since previous studies have reported that hydroquinone (HQ) exerted immunosuppressive and anti-inflammatory activity, various HQ derivatives have been synthesized and their biological activities investigated. In this study, we explored the anti-inflammatory activity of JS-III-49, a novel HQ derivative, in macrophagemediated inflammatory responses. JS-III-49 suppressed the production of the inflammatory mediators nitric oxide (NO) and prostaglandin E2 (PGE2) and downregulated the mRNA expression... -
Hydrogen peroxide attenuates refilling of intracellular calcium store in mouse pancreatic acinar cells
MiNaYoon, DongKwanKim, SeHoonKim, HyungSeoPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 11 233-239 (7 pages)
Intracellular calcium (Ca2+) oscillation is an initial event in digestive enzyme secretion of pancreatic acinar cells. Reactive oxygen species are known to be associated with a variety of oxidative stress-induced cellular disorders including pancreatitis. In this study, we investigated the effect of hydrogen peroxide (H2O2) on intracellular Ca2+ accumulation in mouse pancreatic acinar cells. Perfusion of H2O2 at 300 μM resulted in additional elevation of intracellular Ca2+ levels and... -
Effects of high glucose with or without other metabolic substrates on alpha-adrenergic contractions in rat mesenteric and femoral arteries
RanyVorn, HaeYoungYoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 11 91-97 (7 pages)
Hyperglycemia is associated with an increased risk of cardiovascular diseases. It has been demonstrated that chronic exposure to high glucose impaired endothelial functions. However, specific effects of short-term exposure to high glucose on vascular reactivity are controversial. Moreover, the combined effects of other metabolic substrates such as free fatty acids (FFA) on vascular reactivity remain poorly understood. Here we investigate the effects of short-term exposure to high glucose with or... -
Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice
MinhCongNguyen, SungwooRyoo 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 10 83-90 (8 pages)
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the activity of endothelial nitric oxide synthase (eNOS) and limits NO generation. Hence, arginase inhibition is suggested to be vasoprotective in aging. In this study, we examined the effects of intravenous injection of Piceatannol, an arginase inhibitor, on aged mice. Our results show that Piceatannol...
