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전체 선택해제
총 174건 검색
본문검색 결과만 보기
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Sequence Analysis of Canine LINE-1 Elements and p53 Gene in Canine Transmissible Venereal Tumor
Young-Ki Choi and Chul-Joong Kim 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 6 285-292 (8 pages)
(ORFs), ORF1 and ORF2. We analysed the ORF2 located in the 5' region to the first exon of oncogene c-myc in canine transmissible venereal tumor (TVT) cell. We also showed the transcription activation was induced by this TVT-LINE sequence using CAT assay. To identify the mutation of tumor suppressor gene, sequence analysis of p53 from TVT cell was performed. We identified the point mutation of 964 nucleotide (T-C) resulting in the change of amino acid (Phe-Ser) of p53 tumor suppressor protein. -
Neural Substrates of Motor Imagery： Event-related Functional MRI Study
Seung-Schik Yoo, Byung Gil Choi, Kyu-In Chung, Chang-Uk Lee 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 2001, 제 40권 제 6호 25 1247-1256 (10 pages)
연구목적： 본 연구의 목적은 가상운동 과정시 대뇌 어느 부위가 활성화되는지를 알아보기 위하여 사건-관련 기능적 자기 공명영상을 통해 평가하였다. 방 법： 9명의 오른손잡이 정상인들에게 뇌 전 영역을 포괄한 일련의 T2강조 자기공명 영상을 얻기 위해 1.5 Tesla 자 기공명 영상장치를 사용하였다. 음성 자극 신호에 따라 오른손을 쥐는 상상을 하게 한 후, 그 결과 발생하는 가상 운동과 연관된 혈중 산화 수준-의존성 신호 변화들을 측정하였다. 결 과： 측정된 자료를 group 분석한 결과 내측 상부 전두회, 설상엽, 도, 중 /... -
Complete Genome Sequence Analysis of Two Divergent Groups of Sweet potato chlorotic fleck virus Isolates Collected from Korea
Hae-Ryun Kwak, Jaedeok Kim, Mikyeong Kim, Jang-Kyun Seo, Jeong-Soo Kim, Hong-Soo Choi 한국식물병리학회 The Plant Pathology Journal 7 Pages
한국식물병리학회 The Plant Pathology Journal 2018, 34권 5호 11 451-457 (7 pages)
of about 73%. For the first time, we determined the complete genome sequence for the Group II SPCFV isolates. The amino acid sequence identity in coat proteins (CP) between the two groups was over 90%, whereas the amino acid sequence identity in other proteins was less than 80%. In addition, SPCFV Korean isolates had a low amino acid sequence identity (61% CPs and 47% in the nucleotide- binding protein [NaBp] region) to that of Melon yellowing-associated virus (MYaV), a typical Carlavirus. -
Population Analysis of Iranian Potato virus Y Isolates Using Complete Genome Sequence
한국식물병리학회 The Plant Pathology Journal 14 Pages
한국식물병리학회 The Plant Pathology Journal 2016, 32권 1호 5 33-46 (14 pages)
In this study, the full-length nucleotide sequences of four Iranian PVY isolates belonging to PVYN strain were determined. The genome of Iranian PVY isolates were 9,703–9,707 nucleotides long encoding all potyviral cistrons including P1, HC-Pro, P3, 6K1, CI, 6K2, VPg, NIa-Pro, NIb and CP with coding regions of 825, 1,395, 1,095, 156, 1,902, 156, 564, 732, 1,557 and 801 nucleotides in length, respectively. The length of pipo, embedded in the P3 cistron, was 231 nucleotides. Phylogenetic... -
The Sequence of Sequential Investment and Its Competitive Effect
Hyung Rok Yim 인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 9 Pages
인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 2017, 제 7권 제 7호 67 727-735 (9 pages)
sequential investment strategy has the sequence of investments and thus time value is inevitably considered in order to analyze the effect of the sequential investment on firm performance. In the paper, the sequential investment strategy of Korean firms in China is analyzed. Due to their geographical closeness, Korean firms’ direct investments to China is an eye-catching strategic behavior. A theoretic model is proposed to tackle the effect of Korean firms’ Chinese sequential investments. The... -
The effects of stacking sequence on the penetration-resistant behaviors of T800 carbon fiber composite plates under low-velocity impact loading
Furqan Ahmad, Jung-Wuk Hong, Heung Soap Choi, Soo-Jin Park, Myung Kyun Park 한국탄소학회 Carbon Letters 9 Pages
한국탄소학회 Carbon Letters 2015, Vol.16 No.2 6 107-115 (9 pages)
Impact damages induced by a low-velocity impact load on carbon fiber reinforced polymer (CFRP) composite plates fabricated with various stacking sequences were studied experimentally. The impact responses of the CFRP composite plates were significantly affected by the laminate stacking sequences. Three types of specimens, specifically quasi-isotropic, unidirectional, and cross-ply, were tested by a constant impact carrying the same impact energy level. An impact load of 3.44 kg, corresponding to... -
On the Case Alternation in -ko siphta Constructions
Sim Chang-Yong, Lee Jai-Hee 경인교육대학교 교육연구원 The Journal of Education 21 Pages
경인교육대학교 교육연구원 The Journal of Education 2019, Vol.2 No.1 4 37-57 (21 pages)
Languages like Korean allow internal arguments to bear accusative case morphology or nominative case morphology in desiderative constructions such as –ko siphta. Since the event-time of V–ko and that of siphta are different, the current research claims that –ko siphta is bi-clausal. Idiomatic expressions provide supporting evidence for the bi-clausal status. Nominative-accusative case morphology alternation is accounted for by positing an NP at the edge of a clause, while a... -
명화감상을 통한 이야기 만들기가 유아의 상상적 내러티브에 미치는 영향
김미영(Kim Mi-young) 한국교원대학교 유아교육연구소 한국유아교육연구 27 Pages
한국교원대학교 유아교육연구소 한국유아교육연구 2008, 제 10권 제 1호 7 195-221 (27 pages)
본 연구는 명화감상을 통한 이야기 만들기가 유아의 상상적 내러티브의 구조에서 어떠한 영향을 미치는지 그 효과를 알아보고자 하는데 연구의 목적이 있다. 연구대상은 만 5세 유아 40명(실험집단: 20명, 통제집단: 20명)이며 실험집단은 2006년 10월 9일부터 2006년 12월 29일까지 총 12주간에 걸쳐 명화를 감상하고 이야기를 만들어보는 과정(12회)을 실시하였으며 통제집단은 자유선택활동 시간에 생활주제에 따른 언어활동만 실시하였다. 명화감상을 통한 이야기 만들기의 절차는 명화 탐색하기, 명화에 대한 느낌 이야기하기,... -
Genetic characteristics of canine parvovirus2 (CPV2) in Korea
Boyoun Moon, Seong Hee Kim, Yeon Hee Kim, ByongJae So, Kyoung Ki Lee 대한수의학회 대한수의학회 학술대회발표집 2 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 126 274-275 (2 pages)
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Estimation of bacterial population in bovine colostrum
Young Min Son, Kwang Ho Choi, Jin Sung Seo, Kichan Lee, Mi Hye Hwang, Byeong Yeal Jung 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 추계학술심포지움 125 274-274 (1 pages)
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Production of transgenic pigs using a pGFAP-CreERT2/EGFP LoxP inducible system for central nervous system disease models
Seon-Ung Hwang, Kiyoung Eun, Junchul David Yoon, Hyunggee Kim, Sang-Hwan Hyun 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 13 434-445 (12 pages)
Transgenic (TG) pigs are important in biomedical research and are used in disease modeling, pharmaceutical toxicity testing, and regenerative medicine. In this study, we constructed two vector systems by using the promoter of the pig glial fibrillary acidic protein (pGFAP) gene, which is an astrocyte cell marker. We established donor TG fibroblasts with pGFAP-CreERT2/LCMV-EGFPLoxP and evaluated the effect of the transgenes on TG-somatic cell nuclear transfer (SCNT) embryo development. Cleavage... -
A new recombined porcine reproductive and respiratory syndrome virus virulent strain in China
Jian-guo Dong, Lin-yang Yu, Pei-pei Wang, Le-yi Zhang, Yan-ling Liu, Peng-shuai Liang, Chang-xu Song 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 12 89-98 (10 pages)
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases worldwide. In the present study, a new virulent strain of PRRS virus (PRRSV), GDsg, was isolated in Guangdong province, China, and caused high fever, high morbidity, and high mortality in sows and piglets. The genome of this new strain was 15,413 nucleotides (nt) long, and comparative analysis revealed that GDsg shared 82.4% to 94% identity with type 2 PRRSV strains, but only 61.5% identity with type... -
Analysis of structure-function relationship in porcine rotavirus A enterotoxin gene
Sharad Saurabh, Shubhankar Sircar, Jobin J. Kattoor, Souvik Ghosh, Nobumichi Kobayashi, Krisztian Banyai, Obli R. VinodhKumar, U 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 1호 6 35-43 (9 pages)
and tertiary structure and the prediction of post-translational modifications of NSP4 from diarrheic and non-diarrheic piglets revealed no apparent differences. Sequence analysis indicated that nsp4 genes have a multi-phyletic evolutionary origin and exhibit species independent genetic diversity. The results emphasize the evolution of the E9 nsp4 genotype from the E1 genotype and suggest that the diarrhea-inducing capability of porcine RVs may not be exclusively linked to its enterotoxin gene. -
Alginate encapsulation preserves the quality and fertilizing ability of Mediterranean Italian water buffalo (Bubalus bubalis) and Holstein Friesian (Bos taurus) spermatozoa after cryopreservation
Sara Perteghella, Alessandro Gaviraghi, Silvia Cenadelli, Valeria Bornaghi, Andrea Galli, Barbara Crivelli, Barbara Vigani, Dani 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2017, 제 18권 제 1호 11 81-88 (8 pages)
The use of artificial insemination (AI) in buffalo (Bubalus bubalis) is limited by poor ovarian activity during the hot season, seasonal qualitative patterns in semen, low resistance of sperm cells in the female tract, difficulties in estrus detection, and variable estrus duration. Although AI procedures are commonly used in bovine, use of AI has been limited in buffalo. In the zootechnical field, different studies have been conducted to develop techniques for improvement of fertilizing ability... -
Uracil-DNA glycosylase-treated reverse transcription loop-mediated isothermal amplification for rapid detection of avian influenza virus preventing carry-over contamination
Eun-Mi Kim, Hyo-Sung Jeon, Ji-Jung Kim, Yeun-Kyung Shin, Youn-Jeong Lee, Sang-Geon Yeo, Choi-Kyu Park 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 3호 21 421-425 (5 pages)
Here, we describe a uracil-DNA glycosylase (UNG)-treated reverse transcription loop-mediated isothermal amplification (uRT-LAMP) for the visual detection of all subtypes of avian influenza A virus (AIV). The uRT-LAMP assay can prevent unwanted amplification by carryover contamination of the previously amplified DNA, although the detection limit of the uRT-LAMP assay is 10-fold lower than that of the RT-LAMP without a UNG treatment. To the best of our knowledge, this is the first successful... -
Establishment and characterization of an infectious cDNA clone of a classical swine fever virus LOM strain
Gil-Soon Park, Seong-In Lim, Seung-Ho Hong, Jae-Young Song* 대한수의학회 Journal of Veterinary Science 11 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 12 81-91 (11 pages)
isolated from Japan in 1956. Eight DNA fragments representing the genome of the CSFV strain LOM were obtained by RT-PCR. These were used to determine the complete nucleotide sequence and construct a full-length cDNA clone which was called Flc-LOM. Sequence analysis of the recombinant clone (Flc-LOM) revealed the presence of eight mutations, resulting in two amino acid substitutions, when compared to the parental sequence. RNA transcripts of both LOM and Flc-LOM were directly infectious in PK-15... -
Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development
Joong-Sun Kim, Juhwan Kim, Yujin Kim, Miyoung Yang, Hyosun Jang, Sungwoon Kang, Jong-Choon Kim, Sung-Ho Kim, Taekyun Shin*, Chan 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 1호 1 1-6 (6 pages)
Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development. The present study examined the temporal changes of nestin and GFAP protein levels in the postnatal development of the mouse hippocampus. Mouse hippocampi were sampled on postnatal day (PND) 1, 3, 6, 18, and 48. Western blot analysis showed that nestin expression was high at PND 1 and markedly decreased until PND 18.... -
A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans
Muthannan A. Ramakrishnan, Marie R. Gramer, Sagar M. Goyal, Srinand Sreevatsan* 대한수의학회 Journal of Veterinary Science 3 Pages
대한수의학회 Journal of Veterinary Science 2009, 제 10권 제 4호 12 349-351 (3 pages)
As the scientific community scrambles to define the ancestry and lineages of the eight segments of new pandemic H1N1 strain, we looked for unique genetic events in this virus's genome to explain the newly found enhanced virulence and transmissibility among humans. Genome annotations of this virus identified a stop mutation replacing serine at codon 12 (S12Stop) of the PB1-F2 protein, a virulence factor in influenza A viruses. Here, we discuss the significance of this finding and how it may... -
All blood, No stool: enterohemorrhagic Escherichia coli O157:H7 infection
Jang W. Yoon, Carolyn J. Hovde 대한수의학회 Journal of Veterinary Science 14 Pages
대한수의학회 Journal of Veterinary Science 2008, 제 9권 제 3호 1 219-232 (14 pages)
Enterohemorrhagic Escherichia coli serotype O157:H7 is a pathotype of diarrheagenic E. coli that produces one or more Shiga toxins, forms a characteristic histopathology described as attaching and effacing lesions, and possesses the large virulence plasmid pO157. The bacterium is recognized worldwide, especially in developed countries, as an emerging food-borne bacterial pathogen, which causes disease in humans and in some animals. Healthy cattle are the principal and natural reservoir of E.... -
Altered expression of thioredoxin reductase-1 in dysplastic bile ducts and cholangiocarcinoma in a hamster model
Byung-IL Yoon, Dae-Yong Kim, Ja-June Jang, Jeong-Hee Han 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2006, 제 7권 제 3호 1 211-216 (6 pages)
an important event in cholangiocarcinogenesis, especially at early stages including the cellular transformation of candidate bile ducts. Further studies are however required to determine whether TrxR may be a potential target molecule for chemoprevention against cholangiocarcinogenesis. In addition, the molecular mechanism as well as the importance of the loss of TrxR in the development of cholangiocarcinoma, following dysplastic transformation of bile duct cells, also remains to be clarified. -
Requirement of Metabolic Activation for Estrogenic Activity of Pueraria mirifica
Y.S. Lee, J.S. Park, S.D. Cho, J.K. Son, W. Cherdshewasart and K.S. Kang 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2002, 제 3권 제 4호 4 273-277 (5 pages)
A wide range of chemicals derived from plant and human-made xenobiotics are reported to have hormonal activities. The present study was performed to examine the estrogenic effect of Kwao Keur, Pueraria mirifica (PM), that has been used as a rejuvenating folk medicine in Thailand, using recombinant yeast, MCF-7 cell proliferation and HepG2 cell transient transfection assay. In recombinant yeast assay, 0.025, 0.25, 2.5, 25, 2.5 x 10(2), 2.5 x 10(3), 2.5 x 10(4) ng/ml concentrations of PM did not... -
Expression of caveolin-3 as positive intracellular signaling regulator on the development of hypertrophy in cardiac tissues
JooHeonKim, JinHan, YongKwonKim, YoungAeYang, YongGeunHong 대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 8 Pages
대한수의학회 Korean Journal of Veterinary Research(구 대한수의학회지) 2005, 제 45권 제 4호 12 537-544 (8 pages)
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풍납토성 축조연대의 고고과학적 연구
이성준(Sungjoon Lee), 김명진(Myungjin Kim), 나혜림(Hyerim Na) 한국고고학회 한국고고학보 30 Pages
한국고고학회 한국고고학보 2013, 제 88집 2 42-71 (30 pages)
고고층서학적 정보는 유적의 형성 및 후퇴적과정을 이해하기 위한 고고자료의 시계열을 제공하고, 자연과학적 절대연대의 정밀도를 향상시키는 데 기여할 수 있다. 특히 고고학적 계기성을 사전확률모형으로 채택하는 베이지안 통계학은 고고자료의 시간적 순서(상대연대)를 자연과학적으로 뒤바꾸거나 타당성을 검토하는 것이 아니라, 고고자료와 공반된 연대자료를 토대로 물질문화의 변화폭보다 짧은 기간에 이루어진 인간행위의 시점을 검토하는 데 활용될 수 있다. 2011년 풍납토성 동성벽의 발굴조사에서는 해리스 매트릭스를... -
한성기 백제 도성의 개발방식 연구
이성준(Sungjoon Lee) 한국고고학회 한국고고학보 44 Pages
한국고고학회 한국고고학보 2017, 제 102집 2 48-91 (44 pages)
그동안 풍납토성에 대한 연구는 성벽의 축조시기와 백제토기의 형성시기를 규명하는 것에 집중되었다. 이것은 백제고고학에서 한성양식 토기복합체의 형성 및 확산, 대형분묘의 등장, 성곽의 출현 등을 연맹 왕국 형성과정에서 발현된 현상으로 인식해 온 것과 크게 무관하지 않다. 하지만 풍납토성 내부에서 진 행된 조사성과를 검토해 보면, 개별 유구의 운용과정을 검토할 수 있는 수준의 고고층서학적 정보가 예상보다 취약하며, 출토된 토기의 형식학적 특성에 의존하여 도출된 결과가 대부분이라는 사실을 알 수 있다. 따라서... -
A STUDY ON THE EXPRESSION OF TYPE I AND TYPE II COLLAGEN GENES AND PROTEINS IN THE DEVELOPING HUMAN MANDIBLE
Yoon-Ah Kook, Sang-Cheol Kim, Eun-Cheol Kim 대한치과교정학회 The Korean Journal of Orthodontics 9 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1995, 제 25권 제 6호 8 723-731 (9 pages)
Type I and type II collagens are considered the major collagens of bone and cartilage respectively. Monitoring the patterns of those gene and protein expressions during development will provide a basis for the understanding of the normal and abnormal growths. This study was undertaken to investigate the expression of collagen genes and proteins involved in the developing human mandible. Fifty embryos and fetuses were studied with Alcian blue-PAS, Masson´s Trichrome, reverse transcription... -
A study on chondrogenic potential in mandibular and limb bud mesenchymal cells of human embryos : A possible role of protein kinase C
Yoon-Ah Kook, Eun-Cheol Kim, Sang-Cheol Kim 대한치과교정학회 The Korean Journal of Orthodontics 10 Pages
대한치과교정학회 The Korean Journal of Orthodontics 1996, 제 26권 제 6호 3 667-676 (10 pages)
We have examined the in vitro stage-related chondrogenic potential of human mandibular and limb bud mesenchyme cells using micromass culture, Our results indicate that limb bud mesenchyme cells as early as stage 16 by Carnegie system (37 days), well before the initiation of in vivo chondrogenesis, have chondrogenic potential which is expressed in micromass culture, These results are correlated with stage-related chondrogenic potential of human limb bud in vivo as a result of Alcian blue... -
음악교육과 아동 지능 발달에 관한 문헌 연구
조은(Eun Cho) 한국음악교육학회 음악교육연구 25 Pages
한국음악교육학회 음악교육연구 2014, 제 43권 제 2호 4 67-91 (25 pages)
‘모차르트 효과’가 대중의 주목을 받던 1990년 초 이후 음악교육이 아동 발달에 주는 음악 외적 효과, 특히 지능 발달에 주는 긍정적인 영향은 많은 대중의 관심을 끌어왔다. 하지만 이에 관한 다양한 속설들이 과장, 왜곡되어 퍼져나가면서 음악교육의 목적과 가치에 대한 오해를 야기하게 되었다. 이에 본 연구는 음악교육이 주는 다양한 음악 외적 효과, 특히 지능 발달에 관해 2000년 이후 국제 학술지에 발표된 문헌들을 체계적으로 고찰하여 이에 관해 보고된 연구 결과들을 정리하고 학계의 연구 동향을 소개하고자 한다. 많은... -
이차구개 형태분화의 내적 조절유전자 규명
이재국, 장은하, 임양희, 김기병, 고승오, 조의식, 신효근 대한구순구개열학회 대한구순구개열학회지 16 Pages
대한구순구개열학회 대한구순구개열학회지 2007, 제 10권 1호 1 1-16 (16 pages)
이차구개는 발생과정에서 구개선반의 형성과 성장, 거상과 융합의 과정을 통해 형성된다. 이와 같은 이차구개의 형성과정은 미세한 분자유전학적 신호전달기전에 의해 조절되는 것으로 알려져 있어서, 신호전달과정에 관여하는 유전인자의 발현이상이 되면 정상적인 이차구개가 형성되지 못하고 구개파열이라는 선천성 기형이 발생된다. 구개파열의 유발인자들에 대한 많은 연구에도 불구하고 현재까지 정상적인 이차구개의 형성을 조절하는 분자유전학적 기전에 대해서는 명확히 알려져 있지 않다. 따라서 본 연구에서는 이차구개의... -
Intracellular calcium-dependent regulation of the sperm-specific calcium-activated potassium channel, hSlo3, by the BKCa activator LDD175
TharakaDarshanaWijerathne, JihyunKim, DongkiYang, KyuPilLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.2 12 241-249 (9 pages)
Plasma membrane hyperpolarization associated with activation of Ca2+-activated K+ channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary γ2- subunit, LRRC52 (leucine-rich-repeat–containing 52), is known to mediate the pHsensitive, sperm-specific K+ current KSper in mice, the molecular identity of this channel in human sperm remains controversial. In this study, we tested the classical BKCa activators,... -
The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line
HanSangKim, Su-JinKim, JinhyungBae, YiyiWang, SunYoungPark, YoungSilMin, HyunDongJe, UyDongSohn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 5 595-603 (9 pages)
Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is known to be an important downstream kinase of p44/42 MAPK. We investigated the role of p90rsk on ethanol-induced cell proliferation of HepG2 cells. HepG2 cells were treated with 10~50 mM of ethanol with or without ERK and p90rsk inhibitors. Cell viability was measured by MTT assay. The... -
Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatin
Ji-YoungHong, KenjirouHara, Jun-WooKim, EisukeF.Sato, EunBoShim, Kwang-HyunCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 6 367-378 (12 pages)
Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a comprehensive approach to delineate the biological interactions of the molecules is required. However, quantitative modeling of the mitochondria-ROS generating pathway based on experiment and systemic analysis using the model have not been attempted so far. Thus, we conducted experiments... -
Myosin VI contributes to malignant proliferation of human glioma cells
RongXu, Xu-haoFang, PingZhong 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 1 139-145 (7 pages)
Previously characterized as a backward motor, myosin VI (MYO6), which belongs to myosin family, moves toward the minus end of the actin track, a direction opposite to all other known myosin members. Recent researches have illuminated the role of MYO6 in human cancers, particularly in prostate cancer. However, the role of MYO6 in glioma has not yet been determined. In this study, to explore the role of MYO6 in human glioma, lentivirus-delivered short hairpin RNA (shRNA) targeting MYO6 was... -
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-κB
YongKim, EunJeongJeong, In-SookHanLee, Mi-YeonKim, JaeYoulCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.1 12 91-99 (9 pages)
(E )-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported that some propenone-type compounds display anti-inflammatory activity, we investigated whether MPP could negatively modulate inflammatory responses. To do this, we employed lipopolysaccharide (LPS)-stimulated macrophage-like RAW264.7 cells... -
Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress
BoZhang, BingWang, ShuhuaCao, YongqiangWang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 3 491-497 (7 pages)
Traumatic brain injury (TBI) is a major cause of mortality and long-term disability, which can decrease quality of life. In spite of numerous studies suggesting that Epigallocatechin-3- gallate (EGCG) has been used as a therapeutic agent for a broad range of disorders, the effect of EGCG on TBI remains unknown. In this study, a weight drop model was established to evaluate the therapeutic potential of EGCG on TBI. Rats were administered with 100 mg/kg EGCG or PBS intraperitoneally. At different... -
Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation
GunKang, YuRanLee, HeeKyoungJoo, MyoungSooPark, Cuk-SeongKim, SungaChoi, ByeongHwaJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 10 467-472 (6 pages)
Histone deacetylase (HDAC) has been recognized as a potentially useful therapeutic target for car-diovascular disorders. However, the effect of the HDAC inhibitor, trichostatin A (TSA), on vasoreactivity and hypertension remains unknown. We performed aortic coarctation at the inter-renal level in rats in order to create a hypertensive rat model. Hypertension induced by abdominal aortic coarctation was significantly suppressed by chronic treatment with TSA (0.5 mg/kg/day for 7 days). Nicotinamide... -
The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling
SungRyulLee, SuJinNoh, JuliusRyanPronto, YuJeongJeong, HyoungKyuKim, InSungSong, ZhelongXu, HyogYoungKwon, SeChanKang, Eun-HwaSohn, KyungS 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 1 389-400 (12 pages)
Zinc has been considered as a vital constituent of proteins, including enzymes. Mobile reactive zinc (Zn2+) is the key form of zinc involved in signal transductions, which are mainly driven by its binding to proteins or the release of zinc from proteins, possibly via a redox switch. There has been growing evidence of zinc’s critical role in cell signaling, due to its flexible coordination geometry and rapid shifts in protein conformation to perform biological reactions. The importance and... -
Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms
JoungHoonAhn, MinHyeKim, HyungJooKwon, SooYoungChoi, HyeokYilKwon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.1 7 43-50 (8 pages)
Palmitic acid (PAM), one of the most common saturated fatty acid (SFA) in animals and plants, has been shown to induce apoptosis in exocrine pancreatic AR42J cells. In this study, we investigated cellular mechanisms underlying protective effects of oleic acid (OLA) against the lipotoxic actions of PAM in AR42J cells. Exposure of cells to long-chain SFA induced apoptotic cell death determined by MTT cell viability assay and Hoechst staining. Co-treatment of OLA with PAM markedly protected cells... -
cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus
SangBaeYoo, SeoulLee, JooYoungLee, Bom-TaeckKim, Jong-HoLee, JeongWonJahng 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 7 333-337 (5 pages)
Gene expression of neuronal nitric oxide synthase (nNOS) changes in the hypothalamic paraventricular nucleus (PVN) depending on feeding conditions, which is decreased during food deprivation and restored by refeeding, and phosphorylated cAMP response element binding protein (pCREB) was suggested to play a role in its regulation. This study was conducted to examine if the fasting-induced down-regulation of the PVN-nNOS expression is restored by activation of cAMP-dependent protein kinase A... -
Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
Jung-HeeLee, Hyang-MinCheong, Mi-YoungKang, Sang-YoungKim, YoonsungKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.5 2 343-348 (6 pages)
53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage response proteins, including Ճ-H2AX, MDC1, and BRCA1. The recruitment of 53BP1 requires a tandem Tudor fold which associates with methylated histones H3 and H4. It has already been determined that the majority of DNA damage response proteins are phosphorylated by ATM and/or ATR after DNA... -
Expression of Endothelin-1 and Its Receptors in Cisplatin-Induced Acute Renal Failure in Mice
SeokwooLee, DowhanAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.4 4 149-154 (6 pages)
Endothelin-1 (ET-1) is unequivocally elevated in the kidney with ischemic acute renal failure (ARF), whereas ET receptors (ETAR and ETBR) are variably expressed. Although renal functional and structural changes are similar between ischemic and nephrotoxic ARF, there are few reports on the alteration in the ET system in nephrotoxic ARF. This study was, therefore, undertaken to investigate changes in renal expression of ET-1 and its receptors in nephrotoxic ARF induced by cisplatin. Mice were... -
Effects of TGF-β;1 Ribbon Antisense on CCl4-induced Liver Fibrosis
Kyung-OhDoh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.1 1 1-6 (6 pages)
Ribbon-type antisense oligonucleotide to TGF-<FONT FACE="HJ중명조">Ղ1 (TGF-<FONT FACE="HJ중명조">Ղ1 RiAS) was designed and tested to prevent or resolve the fibrotic changes induced by CCl4 injection. When Hepa1c1c7 cells were transfected with TGF-<FONT FACE="HJ중명조">Ղ1 RiAS, the level of TGF-<FONT FACE="HJ중명조">Ղ1 mRNA was effectively reduced. TGF-<FONT FACE="HJ중명조">Ղ1 RiAS, mismatched RiAS, and normal saline were each injected... -
Gene Expression Profile in Microglia following Ischemia- Reperfusion Injury
JuHyeonOh, HyungSooHan, JaeSikPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2006, Vol.10 No.4 2 173-180 (8 pages)
Microglial activation is thought to play a role in the pathogenesis of many brain disorders. Therefore, understanding the response of microglia to noxious stimuli may provide insights into their role in disorders such as stroke and neurodegeneration. Many genes involved in this response have been identified individually, but not systematically. In this regards, the microarray system permitted to screen a large number of genes in biological or pathological processes. Therefore, we used microarray... -
Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced
ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 7 43-50 (8 pages)
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against PMNs. Therefore, we hypothesized that amrinone could attenuate PMNs-induced cardiac dysfunction by suppression of reactive oxygen species (ROS) produced fby PMNs. In the present study, we examined the effects of amrinone on isolated ischemic (20 min) and reperfused... -
Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
ISo, , IAshmole, HSoh, CSPark, PJSpencer, MLeyl, PRStanfield, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.3 3 131-142 (12 pages)
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or His). Such channels are highly selective for K+, but show inward rectification that is a shallow function of voltage compared with that found in wild type. This inward rectification occurs with a reduced affinity for spermine and persists in the absence of polyamines. Though the unitary current-voltage relation... -
Involvement of NAD(P)H Oxidase in a Potential Link between Diabetes and Vascular Smooth Muscle Cell Proliferation
HyeYoungJeong, MiRanYun, ChiDaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 9 103-109 (7 pages)
The cellular mechanisms that contribute to the acceleration of atherosclerosis in diabetes are poorly understood. Therefore, the potential mechanisms involved in the diabetes-dependent increase in vascular smooth muscle cell (VSMC) proliferation was investigated. Using primary culture of VSMC from streptozotocin-induced diabetic rat aorta, cell proliferation assay showed two-fold increase in cell number accompanied with enhanced superoxide generation compared to normal VSMC, 2 days after... -
Inhibition of NF-κB Activation Increases Oxygen-Glucose Deprivation-Induced Cerebral Endothelial Cell Death
JinuLee, ChulHoonKim, KyuDaeShim, YoungSooAhn 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.2 3 65-71 (7 pages)
Increasing evidences suggest that ischemia-induced vascular damage is an integral step in the cascade of the cellular and molecular events initiated by cerebral ischemia. In the present study, employing a mouse brain endothelioma-derived cell line, bEnd.3, and oxygen-glucose deprivation (OGD) as an in vitro stroke model, the role of nuclear factor kappa B (NF-κB) activation during ischemic injury was investigated. OGD was found to activate NF-κB and to induce bEnd.3 cell death in a... -
Functional Abnormalities of HERG Mutations in Long QT Syndrome 2 (LQT2)
MasayasuHIRAOKA 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.5 1 367-371 (5 pages)
The chromosome 7-linked long QT syndrome (LQT2) is caused by mutations in the human ether-a- go-go-related gene (HERG) that encodes the rapidly activating delayed rectifier K+ current, IKr, in cardiac myocytes. Different types of mutations have been identified in various locations of HERG channel. One of the mechanisms for the loss of normal channel function is due to membrane trafficking of channel protein. The decreased channel function in some deletion mutants appears to be due to loss of...
