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폐경기 비만의 임상적 의의에 대한 문헌적 고찰
양미성(Mi Sung Yang), 신미숙(Mi Suk Shin), 안혜림(Hye Lim An) 한방비만학회 대한한방비만학회지 13 Pages
한방비만학회 대한한방비만학회지 2008, 제 8권 제 2호 1 1-13 (13 pages)
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NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts
VuThiThu, HyoungKyuKim, LeThanhLong, ToThanhThuy, NguyenQuangHuy, SoonHaKim, NariKim, KyungSooKo, ByoungDooRhee, JinHan 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 10 305-314 (10 pages)
of this study was to further define the role and mechanism of action of NecroX-5 in regulating infl ammation and fi brosis responses in a model of hypoxia/reoxygenation (HR). We utilized HR-treated rat hearts and lipopolysaccharide (LPS)-treated H9C2 culture cells in the presence or absence of NecroX-5 (10 μmol/L) treatment as experimental models. Addition of NecroX-5 signifi cantly increased decorin (Dcn) expression levels in HR-treated hearts. In contrast, expression of transforming growth... -
The Efficacy of Shikonin on Cartilage Protection in a Mouse Model of Rheumatoid Arthritis
YoungOckKim, SeungJaeHong, Sung-VinYim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.4 1 199-204 (6 pages)
The potential therapeutic action of shikonin in an experimental model of rheumatoid arthritis (RA) was investigated. As a RA animal model, DBA/1J mice were immunized two times with type II collagen. After the second collagen immunization, mice were orally administered shikonin (2 mg/kg) once a day for 35 days, and the incidence, clinical score, bone mineral density (BMD), bone mineral content (BMC) and joint histopathology were evaluated. BMD in the proximal regions of the tibia largely... -
Effects of R. Glutinosa and E. Senticosus on Postmenopausal Osteoporosis
SooYeonOh, DipendraKumarAryal, Yoon-GyoonKim, , Hyung-GunKim, 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 7 121-127 (7 pages)
In this study, we investigated the therapeutic effects of a novel formulation of low-dose calcium and vitamin D3, blended with Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max (RE), in postmenopausal women. The controls were given either a placebo or high dose calcium and vitamin D3 (CaD). Bone mineral density (BMD) in the L2-3 lumber spines and femur regions was assessed, and serum osteocalcin, bone-specific alkaline phosphatase (BALP), and cross-linked N-telopeptide... -
Effects of Dexamethasone and DHEA on the Changes of Glutamate and Polyamine Uptake in Rat Astrocytes by Lipopolysaccharide and Antimycin A
Sang-HyunChoi, BumLee, Kyung-HoShin, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 3 137-146 (10 pages)
Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of dexamethasone and DHEA on the regulatory role of astrocytes in conditions of increased extracellular concentrations of glutamate or polyamines. 1. [3H]Glutamate uptake: LPS and antimycin A decreased Vmax, but both drugs had little effect on... -
Effects of Dexamethasone and DHEA on the Responses of Rat Cerebral Cortical Astrocytes to Lipopolysaccharide and Antimycin A
Sang-HyunChoi, Hyung-GunKim, Chang-KeunKim, Nan-HyangPark, Dong-HeeChoi, In-SopShim, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 2 127-135 (9 pages)
of a study on the effects of dexamethasone and dehydroepiandrosterone (DHEA) on the biological roles of astrocytes in brain injury, this study evaluated the effects of dexamethasone and DHEA on the responses of primary cultured rat cortical astrocytes to lipopolysaccharide (LPS) and antimycin A. Dexamethasone decreased spontaneous release of LDH from astrocytes, and the dexamethasone effect was inhibited by DHEA. However, the inhibitory effect of DHEA on the dexamethasone-induced decrease of LDH... -
Lipocortin 1 Mediates the Suppressive Effects of Dexamethasone on ConA-induced Proliferative Response and Nitric Oxide Production in Rat Splenic Leukocytes
YeonJinJang, HyoungsupPark, SoonAKang, SusJungYang, DoeSunNa 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 12 91-96 (6 pages)
Lipocortin 1 has been proposed as a putative mediator of anti-inflammatory actions of glucocorticoids. We investigated the role of lipocortin 1 in the effect of dexamethasone using rat splenic leukocytes. Concanavalin A(ConA; 1 ㄍg/ml) increased the leukocyte proliferation and nitric oxide(NO) generation, which were measured as [3H]-thymidine uptake by the cells and nitrite accumulation in the culture media, respectively. Dexamethasone suppressed ConA-induced cell proliferation, in a... -
주요 우울 장애 환자의 면역기능에 관한 연구
김용희, 이재광, 박두병 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1997, 제 36권 제 3호 5 457-465 (9 pages)
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흰쥐에서 반복적 스트레스가 신경활성 스테로이드의 GABAA 수용체 조절작용에 미치는 영향
장봉석, 이종범, 박형배, 하정희, 송창진 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1999, 제 38권 제 3호 20 656-663 (8 pages)
연구목적： 신경활성 스테로이드는 대뇌피질 세포막의 GABAA 수용체 복합체에서 GABAA 수용체 효현제 양상으로 작용하여 [3H]flunitrazepam이 GABAA 수용체에 결합하는 항진 작용이 관찰되었으나, 반복적으로 신경활성 스테로이드를 처치한 세포에서는 이러한 신경활성 스테로이드의 [3H]flunitrazepam 결합 항진효과가 소실 되었다는 보고가 있었다. 이에 본 연구에서는 반복적인 스트레스에 부하된 흰쥐를 사용하여 신경활성 스테로 이드의 GABAA 수용체에 대한 배위자(ligand)의 결합반응 양상을 정상 실험동물과 비교, 관찰하여... -
정신분열병 환자에서 리스페리돈의 투여에 따른 혈청 코티졸과 임상증상의 변화
김광수, 성양숙, 채정호, 박원명, 이정태, 전태연 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 2호 11 381-389 (9 pages)
연구목적： 세로토닌 5HT2 수용체의 자극이 코티졸 분비를 증가시킨다는 점에서, 강력한 5HT2길항제인 risperidone은 정신분열병에서 보이는 시상하부-뇌하수체-부신축의 과활성화에 대하여 영향을 미칠 것이라고 생 각되었다. 저자들은 세로토닌 5HT2 길항제인 risperidone에 의한 코티졸의 양적변화를 통하여 신경생리학 적인 변화를 추적하고 나아가 정신분열병의 병태생리에서 세로토닌과 코티졸의 병리학적 역할에 대하여 알 아보고자 하였다. 방 법： 본 연구는 가톨릭대학교 성모병원 신경정신과에 입원했던 DSM-Ⅳ 진단기준에...
