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Pitavastatin Regulates Ang II Induced Proliferation and Migration via IGFBP-5 in VSMC
YuMiHa, Ju-OckNam, YoungJinKang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.6 4 499-506 (8 pages)
Angiotensin II (Ang II), a key mediator of hypertensive, causes structural changes in the arteries (vascular remodeling), which involve alterations in cell growth, vascular smooth muscle cell (VSMC) hypertrophy. Ang II promotes fibrotic factor like IGFBP5, which mediates the profibrotic effects of Ang II in the heart and kidneys, lung and so on. The purpose of this study was to identify the signaling pathway of IGFBP5 on cell proliferation and migration of Ang II-stimulated VSMC. We have been... -
Role of T-type Ca2＋ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle
Si-EunLee, Duck-SunAhn, Young-HoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.3 15 241-249 (9 pages)
Although extracellular Ca2＋ entry through the voltage-dependent Ca2＋ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2＋ channels has yet to be fully identified. The aim of this study was to investigate the role of the T-type Ca2＋ channel in the spontaneous phasic contractions of the rat myometrium. Spontaneous phasic contractions and [Ca2＋]i were measured simultaneously in the longitudinal strips of female... -
Anti-ischemic Effect of Polygala Tenuifolia in Isolated Rat Heart
Chang-WonKang, Jong-HoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 3 89-95 (7 pages)
Polygala tenuifolia (PT) is one of the most well-known traditional herbal medicines in Korea which is commonly used for the treatment of cardiovascular symptoms. The anti-ischemic effects of PT in isolated rat heart was investigated by analyzing changes in blood pressure, aortic flow, coronary flow, and cardiac output. And, its underlying mechanism was examined by quantitating intracellular calcium content in rat neonatal cardiomyocytes. Rats were divided into two groups: an ischemia-induced... -
기니픽 심장과 심근 세포에서 α1-Adrenergic 자극에 의한 Mg2+ 유리조절 Regulation of Mg2+ Release in Guinea Pig Heart and Isolated Ventricular Myocytes by Ձ1-Adrenergic Stimulation
강형섭, 장성은, 김진상, Hyung-SubKang, Sung-EunChang, Jin-SangKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 14 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 13 717-730 (14 pages)
Mg2 is the fourth most abundant cation in cellular organisms. Although the biological chemistry and the physiological roles of the magnesium ion were well known, the regulation of intracellular Mg2 in mammalian cells is not fully understood. More recently, however, the mechanism of Mg2 mobilization by hormonal stimulation has been investigated in hearts and in myocytes. In this work we have investigated the regulation mechanism responsible for the Mg2 mobilization... -
Procainamide와 그 대사산물(N-acetylprocainamide)의 약동학적 분석에 관한 연구
장인진(In-Jin Chang), 신재국(Jae-Gook Shin), 신상구(Sang-Goo Shin), 박찬웅(Chan-Woong Park), 임정규(Jung-Kyoo Lim) 대한약리학회 대한약리학잡지 8 Pages
대한약리학회 대한약리학잡지 1989, 제 25권 제 1호 12 101-108 (8 pages)
Procainamide를 투여후 이 약물 및 활성형 대사산물인 N-acetylprocainamide (NAPA)의 약동학적 성상을 알아보기 위해 숫컷 성견 5마리에 procainamide 및 NAPA를 교차 투여하여 얻은 혈장농도 data를 2-compartmental model에 의해 약동학적 분석을 시행하여 다음과 같은 결과를 얻었다. 1. 10mg/kg의 procainamide를 1회 15분간 정주후 혈장 procainamide 농도변화는 명백한 분포기와 소실기를 보였으며 생성된 NAPA의 혈장농도는 시간경과에 따라 최고혈장농도는 0.124μg/ml 이하이었으며 정주 직후 조직분포에 따른 혈장농도의... -
심방세동 환자 대상 주요 연구주제 및 관련 측정도구 분석 : 국내 간호학 분야 논문을 중심으로 (2000-2017)
손연정, 백경화 인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 14 Pages
인문사회과학기술융합학회 예술인문사회융합멀티미디어논문지 2017, 제 7권 제 10호 61 669-682 (14 pages)
본 연구는 심방세동 환자 대상으로 실시된 국내 간호학분야 논문의 주요 연구주제 및 관련 측정도구를 분석하여, 향후 심방세동 관련 국내 간호연구의 방향제시 및 새로운 간호중재 개발 을 위한 기초자료를 제공하고자 실시되었다. 연구방법: 본 연구의 자료조사 기간은 2000년 1월부터 2017년 6월까지였으며, 국내 3개 데이터베이스에서 ‘심방세동’, ‘환자’, ‘간호’로 주요 키워드를 선정, 조합하여 분석한 결과 최종 11편의 논문이 선정되었다. 연구결과: 분석대상 11편 논문은 학술지 논문 7편, 석·박사학위논문 4편이었다.... -
DOCA-Salt를 이용한 SHR의 복합질환 모델 구축
이한기, 노민희, 박수경, 홍용근 한국보건기초의학회 한국보건기초의학회지 6 Pages
한국보건기초의학회 한국보건기초의학회지 2008, Vol.1 No.1 1 1-6 (6 pages)
There are two types of hypertension such as primary or essential hypertension (90%) and the secondary makes up the rest. Even though, many intracellular signaling molecules may contribute to the cardiac hypertrophy as primarily or secondary regulatory molecule in spontaneously hypertensive rat (SHR), it remains unknown whether establishment of complex hypertensive animal model using deoxycorticosterone acetate (DOCA) in SHR is possible or not. Thus, the present study aimed to evaluate effect of...
