There are two types of hypertension such as primary or essential hypertension (90%) and the secondary makes up the rest. Even though, many intracellular signaling molecules may contribute to the cardiac hypertrophy as primarily or secondary regulatory molecule in spontaneously hypertensive rat (SHR), it remains unknown whether establishment of complex hypertensive animal model using deoxycorticosterone acetate (DOCA) in SHR is possible or not. Thus, the present study aimed to evaluate effect of the additional induction of hypertension using DOCA-salt in SHR. Strikingly, profound raised blood pressure were revealed in DOCA-WKY rat (71.5% vs. WKY) and DOCA-SHR (63.7% vs. SHR). Interestingly, the body weight as parameter following physiological growth were significantly decreased in DOCA-WKY rats (7.3% vs. WKY) as well as DOCA-SHR (6.9% vs. SHR). These results suggest that DOCA-SHR animal model might be available for investigation of incidental mechanisms between cardiogenic hereditary hypertension and secondary metabolic hypertension.