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전체 선택해제
총 555건 검색
본문검색 결과만 보기
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ATP-Sensitive K+ Currents in Gastric Myocytes Isolated from Guinea-pig
JaeYeoulJun, CheolHoYeum, PyungJinYun, JongSeongPark, SungJoonKim, InsukSo, KiWhanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 11 85-93 (9 pages)
ATP-sensitive K+ channels (KATP) were not identified in gastric smooth muscle cells. However， in tension recording of intact gastric circular muscle， lemakalim of KATP channels opener in other tissues suppressed mechanical contractions and this effect was blocked by glibenclamide， a specific inhibitor of KATP channels. The aims of this study were to investigate whether KATP channels exist in gastric smooth muscle of guinea-pig and to know its physiological role. Whole cell K'+ curr‘ents... -
비-혈관평활근에서 새로운 K+ 동로 개방제인 SKP-450의 약리 학적 작용의 특성 -Levcromakalim의 작용과 비 교
홍기환, 박지영, 김현희, 유성은 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 17 759-767 (9 pages)
In Vitro Pharmacological Characteristics of SKP-450， A Novel K+ Channel Opener， in Non-Vascular Smooth Muscles in Comparison with Levcromakalim. Ki Whan HongI， Ji Young Park\ Hyun Hee Kim\ and Sung-Eun Y002 lDepartment of Pharmacology， College of Medicine， Pusan National University， Pusan， 602-739; and 2Korea Research Institute of Chemical Technology， Daejeon， Korea In the present study， we characterized the non-vascu1ar smooth musc1e relaxant effects of a novel benzoyran derivative，... -
고압산소 전처치의 섬근 항산화효소 활성 증가 및 허혈-재관류손상 보호 효과
오동진, 김영훈, 김찬형, 박종완, 김명석 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 16 749-758 (10 pages)
Pretreatment of Hyperbaric Oxygenation Increases the Activities of Myocardial Antioxidant Enzymes and Protects the Ischen뻐-Reperfusion Injury of the Heart. Dong Jin OhI， Young-hoon Kim， Chan-hyung Kim， Jong-wan Park， and Myung-suk Kim lDepartment of Intemal Medicine， Gangdong Sacred Heaπ Hospital， College of Medicine， Hallym University; Department of Phannacology， College of Medicine， Seoul N ational University， Seoul 110 -799， Korea -
흰쥐 대뇌피질 절편에서 허혈에 의한 Norepinephrine 유리에 있어서 Nitric Oxide의 영향 Role of Nitric Oxide in Ischemia-evoked Release of Norepinephrine from Rat Cortex Slices
김기원, 은영아, 김동찬, 조규박, Kee-WonKim, YoungAhEun, Dong-ChanKim, Kyu-ParkCho 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.6 8 673-679 (7 pages)
It has been generally accepted that glutamate mediates the ischemic brain damage, excitotoxicity, and induces release of neurotransmitters, including norepinephrine(NE), in ischemic milieu. In the present study, the role of nitric oxide(NO) in the ischemia-induced [3H]norepinephrine([3H]NE) release from cortex slices of the rat was examined. Ischemia, deprivation of oxygen and glucose from Mg2-free artificial cerebrospinal fluid, induced significant release of [3H]NE from cortex slices.... -
Role of Intracellular Taurine in Monensin-induced Na+, Ca++ Accumulation and Mechanical Dysfunction in Isolated Rat Hearts
Young-hoonKim, Jong-wanPark, Myung-sukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.5 9 537-546 (10 pages)
It has been postulated that the intracellular taurine is co-transported with Na down a concentration gradient and prevents the intracellular accumulation of sodium. It is therefore, expected that an elevated level of intracellular taurine prevents the sodium-promoted calcium influx to protect the cellular damages associated with sodium and calcium overload. In the present study, we evaluated the effects of intra- and extracellular taurine on the myocardial Na and Ca... -
Changes in Renal Brush-Border Sodium-Dependent Transport Systems in Gentamicin-Treated Rats
SoongYongSuhl, DoWhanAhn, KyoungRyongKim, JeeYeunKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 7 403-411 (9 pages)
To elucidate the mechanism of gentamicin induced renal dysfunction, renal functions and activities of various proximal tubular transport systems were studied in gentamicin-treated rats (Fisher 344). Gentamicin nephrotoxicity was induced by injecting gentamicin sulfate subcutaneously at a dose of 100 mg/kg·day for 7 days. The gentamicin injection resulted in a marked polyuria, hyposthenuria, proteinuria, glycosuria, aminoaciduria, phosphaturia, natriuresis, and kaliuresis, characteristics of... -
Effect of t-butylhydroperoxide on Na+-dependent Glutamate Uptake in Rabbit Brain Synaptosome
HyunJeLeeYongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 3 367-376 (10 pages)
The effect of an organic peroxide, t-butylhydroperoxide (t-BHP), on glutamate uptake was studied in synaptosomes prepared from cerebral cortex. t-BHP inhibited the Na+-dependent glutamate uptake with no change in the Na+-independent uptake. This effect of t-BHP was not altered by addition of Ca2+ channel blockers (verapamil, diltiazem and nifedipine) or PLA2 inhibitors (dibucaine, butacaine and quinacrine). However, the effect was prevented by iron chelators (deferoxamine and phenanthroline)... -
Platelet-Activating Factor Enhances Interleukin-1 Activity by Alveolar Macrophages Inhibition by PAF Specific Receptor Antagonists
JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 10 201-208 (8 pages)
It is becoming increasingly clear that the inflammatory reaction can be ascribed to a complex array of mediators generated and released from activated phagocytes. In this study, the effect of PAF on interleukin-1(IL-1) activity by rat alveolar macrophages(AM) was examined using thymocyte proliferation assay in the supernate of sample obtained after 24 hr culture. When AM were cultured with PAF alone, no change in IL-1 activity was observed. However, the combined addition of PAF and muramyl... -
Study on Ginseng Protopanaxadiol and Protopanaxatriol Saponins- Induced Antinociception
Young-HeeShin, Seok-ChangKim, Ji-WonHan, Dae-HoonKim, Sang-SubHan, Dong-HoShin, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 4 143-149 (7 pages)
We studied the effects of ginseng protopanaxadiol (PD) and protopanaxatriol (PT) saponins on the analgesia using several pain tests such as writhing, formalin, and tail-flick test. Using mouse, pretreatment of PD or PT saponins (i.p.) induced inhibition of abdominal constrictions caused by 0.9% acetic acid administration(i.p.). The AD50 was around 27 (17-43) mg/kg for PD and 13.5 (3-61) mg/kg for PT saponins in writhing test. Both PD and PT saponins also showed the inhibition of bitings and...
