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351.

The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

JaeWonChoi, JongMinLee, YoungJunOh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2002, Vol.6 No.5 1 235-240 (6 pages)

JaeWonChoi, JongMinLee, YoungJunOh 저
...
- 3,000원
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25μM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation...
352.

Increased Expression of Nitric Oxide Synthases in Left and Right Ventricular Hypertrophy

JongUnLee, YoonWhaOh, SunmiKim, DaeGillKang, WonJungLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 9 65-70 (6 pages)

JongUnLee, YoonWhaOh, SunmiKim, DaeGillKang, WonJungLee 저
...
- 3,000원
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney, one clip (2K1C) hypertensive and treated with monocrotaline (MCT), respectively. Six weeks later, the hearts were taken and their ventricular tissue mRNA and protein expression of endothelial constitutive isoform of nitric oxide synthase (NOS) were determined by...
353.

Role of NF-κB Binding Sites in the Regulation of Inducible Nitric Oxide Synthase by Tyrosine Kinase

YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2001, Vol.5 No.1 8 55-63 (9 pages)

YoungSueRyu, JangHeeHong, JongHoLim, SoHyunBae, IhnSubAhn, JeongHoSeok, JaeHeunLee, GangMinHur 저
...
- 3,000원
In macrophages, lipopolysaccharide (LPS) alone or in combination with interferon-γ (IFN-γ) has been shown to release a nitric oxide (NO) through the increase of the transcription of the inducible nitric oxide synthase (iNOS) gene. To investigate the exact intracellular signaling pathway of the regulation of iNOS gene transcription by LPS plus IFN-γ, the effects of protein tyrosine kinase (PTK) inhibitor and protein kinase C (PKC) inhibitors on NO production, iNOS mRNA expression, nuclear...
354.

Role of Shc and Phosphoinositide 3-Kinase in Heregulin-Induced Mitogenic Signaling via ErbB3

MyongSooKimJohnG.Kol 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2000, Vol.4 No.6 9 497-506 (10 pages)

MyongSooKimJohnG.Kol 저
...
- 3,000원
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular effectors of the ErbB2/ErbB3 are mitogen-activated protein kinase (MAPK) and phosphoinositide (PI) 3-kinase. In the present study, we studied relative contributions of above two distinct signaling pathways to the heregulin-induced mitogenic response via...
355.

Molecular Analysis of AQP2 Promoter. I. cAMP-dependent Regulation of Mouse AQP2 Gene

MiYoungPark, YongHwanLee, HaeRahnBae, RyangHwaLee, SangHoLee, JinSupJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 5 157-164 (8 pages)

MiYoungPark, YongHwanLee, HaeRahnBae, RyangHwaLee, SangHoLee, JinSupJung 저
...
- 3,000원
To determine molecular mechanisms of Aquaporin-CD (AQP2) gene regulation, the promoter region of the AQP2 gene was examined by transiently transfecting a promoter-luciferase reporter fusion gene into mouse renal collecting duct cell lines such as mIMCD-3, mIMCD-K2, and M-1 cells, and NIH3T3 mouse embryo fibroblast cells. PCR-Southern analysis reveals that mIMCD-3 and mIMCD-K2 cells express AQP2, but M-1 and NIH3T3 cells do not, and that the treatment with cpt-cAMP (400μM) or forskolin/...
356.

Effects of Exogenous ATP on Calcium Mobilization and Cell Proliferation in C6 Glioma Cell

Eun-JungLee, SeokHoCha, WoonKyuLee, Kweon-HaengLee, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.4 3 419-425 (7 pages)

Eun-JungLee, SeokHoCha, WoonKyuLee, Kweon-HaengLee, Sang-BokLee 저
...
- 3,000원
To clarify the effect of extracellular ATP in cultured C6 glioma cells, ATP-induced cytosolic free calcium ([Ca2⁢]i) mobilization and cell proliferation were investigated. ATP-induced [Ca2⁢]i increased in a dose-dependent manner (10⁣7 M∼10⁣3 M). ATP-induced [Ca2⁢]i increases were slightly slowed in extracellular calcium-free conditions especially in sustained phase. ATP-induced [Ca2⁢]i increment was also inhibited by the pretreatment of U73122, a...
357.

Cromakalim Blocks Membrane Phosphoinositide Activated Signals in the Guinea Pig Lung Mast Cells Stimulated with Antigen-Antibody Reactions

JaiYoulRo, JiYoungKim, KyungHwanKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 14 251-260 (10 pages)

JaiYoulRo, JiYoungKim, KyungHwanKim 저
...
- 3,000원
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by inhibiting the initial increase of 1,2-diacylglycerol (DAG) produced by the activation of the other phospholipase system which is different from phosphatidylcholine-phospholipase D pathway. The aim of this study is to further examine the inhibitory mechanism of cromakalim...
358.

Inducible Nitric Oxide Synthase mRNA Expression and Nitric Oxide Production in Silica-Induced Acute Inflammatory Lung Injury

JiheeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.2 12 233-239 (7 pages)

JiheeLee 저
...
- 3,000원
Stimulated alveolar macrophages and neutrophils produce nitric oxide, a free radical by an inducible nitric oxide synthase(iNOS), which reacts with superoxide anion to form peroxynitrite, a more highly reactive toxic species. The objectives of the present study were to evaluate acute inflammatory lung injury and to determine iNOS mRNA induction and nitric oxide production by rat broncho-alveolar lavage cells following intratracheal treatment of silica. After 4 h exposure to silica, differential...
359.

Distributional Patterns of Phospholipase C Isozymes in Heart and Brain of Spontaneously Hypertensive and Normotensive Rats

Ji-WoongChoi, Young-JinCho, SeokHoCha, Kweon-HaengLee, Sang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.4 5 385-392 (8 pages)

Ji-WoongChoi, Young-JinCho, SeokHoCha, Kweon-HaengLee, Sang-BokLee 저
...
- 3,000원
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in the genetic hypertensive rats. As the first step of knowing the role of PLC on hypertension, we investigated the distribution of 6 PLC isozymes (PLC-β1, -β3, -β4, -γ1, -γ2 and -δ1) in the heart and brain, which are concerned with...
360.

백서 뇌 별아교세포에서 LipopolysaccharideI에 의한 Nitric Oxide 생성기전

소광, 박래길, 이상렬, 박민철 대한신경정신의학회 신경정신의학 13 Pages

대한신경정신의학회 신경정신의학 1999, 제 38권 제 4호 20 881-893 (13 pages)

소광, 박래길, 이상렬, 박민철 저
...
- 4,200원
연구목적： Nitric oxide(NO)는 뇌졸중 및 여러 가지 신경변성 질환의 병리생리에 중요한 역할을 한다. 본 연구는 백서 뇌로부터 분리한 별아교세포에서 세균내독소 lipopolysaccharide(LPS)에 의한 NO 생성과정이 MAP kinase cascades와 전사 활성인자 NF-kB에 의해 중재됨을 밝히고자 하는 것이다. 방 법： NO 생성은 Greese’s reagents와 Western blot analysis를 사용하여 측정하였고 Erk, JNK1, p38은 in vitro immunecomplex kinase assay로 측정했다. NF-kB의 전사적 활성은 electrophoretic mobility shift assay로 결정하였다....

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