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581.

Matrix Metalloproteinase Inhibitors Attenuate Neuroinflammation Following Focal Cerebral Ischemia in Mice

CheolHongPark, TaeKyeongShin, HoYounLee, SoJungKim, WonSukLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.2 7 115-121 (7 pages)

CheolHongPark, TaeKyeongShin, HoYounLee, SoJungKim, WonSukLee 저
...
- 3,000원
The aim of this study was to investigate whether matrix metalloproteinase (MMP) inhibitors attenuate neuroinflammation in an ischemic brain following photothrombotic cortical ischemia in mice. Male C57BL/6 mice were anesthetized, and Rose Bengal was systemically administered. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold white light. MMP inhibitors, such as doxycycline, minocycline, and batimastat, significantly reduced...
582.

Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain

YoungJinKang, MinKyuPark, HyunSukLee, HyoungChulChoi, KwangYounLee, HyeJungKim, HanGeukSeo, JaeHeunLee, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2008, Vol.12 No.5 9 275-280 (6 pages)

YoungJinKang, MinKyuPark, HyunSukLee, HyoungChulChoi, KwangYounLee, HyeJungKim, HanGeukSeo, JaeHeunLee, KiChurlChang 저
...
- 3,000원
most significant protection against focal ischemia was obtained in rats with 8 h reperfusion after PC. Administration of indomethacin (10 mg/kg, oral) or rofecoxib (5 mg/kg, oral) 48 h prior to PC counteracted the effect of PC. Immunohistochemical analysis showed that COX-2 and HO-1 protein were induced in PC-treated rat brain, which was significantly inhibited by rofecoxib. Taken together, we concluded that the kinetic changes of COX-2 expression during the reperfusion period after PC might be...
583.

The Role of Janus Kinase in Superoxide-mediated Proliferation of Diabetic Vascular Smooth Muscle Cells

JiYoungLee, JiYoungPark, ChiDaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.1 5 31-36 (6 pages)

JiYoungLee, JiYoungPark, ChiDaeKim 저
...
- 3,000원
To elucidate a potential molecular link between diabetes and atherosclerosis, we investigated the role of Janus tyrosine kinase (JAK) for NAD(P)H oxidase-derived superoxide generation in the enhanced proliferative capacity of vascular smooth muscle cells (VSMC) of Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model of type 2 diabetes. An enhanced proliferative response to 10% fetal bovine serum (FBS) and superoxide generation with an increased NAD(P)H oxidase activity were observed in...
584.

Inhibition of Inducible Nitric Oxide Synthase Expression by YS 49, a Synthetic Isoquinoline Alkaloid, in ROS 17/2.8 Cells Activated with TNF-α, IFN-γ and LPS

YoungJinKang, SunYoungKang, YoungSooLee, MinKyuPark, HyeJungKim, HanGeukSeo, JaeHeunLee, HyeSookYun-Choi, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.5 6 273-280 (8 pages)

YoungJinKang, SunYoungKang, YoungSooLee, MinKyuPark, HyeJungKim, HanGeukSeo, JaeHeunLee, HyeSookYun-Choi, KiChurlChang 저
...
- 3,000원
by Northern and Western blot analysis, respectively. The underlying mechanism by which YS 49 suppressed iNOS expression was not to affect iNOS mRNA stability but to inhibit activation and translocation of NF-κB by preventing the degradation of its inhibitory protein IκBα. As expected, YS 49 prevented NO-induced apoptotic cell death by sodium nitroprusside. Taken together, it is concluded that YS 49 inhibits iNOS expression by interfering with degradation of phosphorylated inhibitory κBα...
585.

Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced

ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2004, Vol.8 No.1 7 43-50 (8 pages)

ByungKwonOh, HyoungKiKim, SooRanChoi, JinHoSong, EonSubPark, Byung 저
...
- 3,000원
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against PMNs. Therefore, we hypothesized that amrinone could attenuate PMNs-induced cardiac dysfunction by suppression of reactive oxygen species (ROS) produced fby PMNs. In the present study, we examined the effects of amrinone on isolated ischemic (20 min) and reperfused...
586.

Caffeic Acid Phenethyl Ester Inhibits the PKC-Induced IL-6 Gene Expression in the Synoviocytes of Rheumatoid Arthritis Patients

Gang-MinHur, Yin-BangHwang, Jae-HeunLee, So-HyunBae, Ji-SunPark, Choong-JaeLee, Jeong-HoSeok 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.6 11 363-368 (6 pages)

Gang-MinHur, Yin-BangHwang, Jae-HeunLee, So-HyunBae, Ji-SunPark, Choong-JaeLee, Jeong-HoSeok 저
...
- 3,000원
To gain insight on the role of pro-inflammatory cytokines in the pathogenesis and treatment of rheumatoid arthritis (RA), the phorbol 12-myristate 13-acetate (PMA)-induced IL-6 gene expression and the effect of caffeic acid phenethyl ester (CAPE) on the PMA-induced IL-6 gene expression were investigated in human fibroblast-like synoviocytes (FLSs). Synovial tissue samples were obtained from rheumatoid arthritis patients, and FLSs were isolated. The cells were stimulated with PMA (100 nM) for 6...
587.

Dietary Ascorbate Supplementation Reduces Oxidative Tissue Damage and Expression of iNOS in the Kidney of Streptozotocin Induced Diabetic Rats

MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2003, Vol.7 No.1 8 39-45 (7 pages)

MyungSeoupChoi, YoonYoungJang, WooSeungLee, JinHoSong, YongKyooShin 저
...
- 3,000원
Reactive oxygen species (ROS) have been suggested to be contributory factors in complications of diabetes mellitus. In the present study, we investigated the generation of superoxide, the lipid peroxide level measured as thiobarbituric acid reactive substances, the vasorelaxation of isolated thoracic aorta and the iNOS expression in kidney of streptozotocin induced diabetic rats. Sprague Dawley rats were divided into four groups: control, ascorbate (400 mg/kg rat weight daily in drinking water),...
588.

Enhanced Expression of Inducible Nitric Oxide Synthase May Be Responsible for Altered Vascular Reactivity in Streptozotocin-induced Diabetic Rats

JaeKwonJang, YoungJinKang, HanGeukSeo, SookJaeSeo, KiChurlChang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.4 2 375-382 (8 pages)

JaeKwonJang, YoungJinKang, HanGeukSeo, SookJaeSeo, KiChurlChang 저
...
- 3,000원
by using Griess reagent and Western analysis, respectively. Results indicated that STZ-treated rats increased the maximal contractile response of the aorta to phenylephrine (PE), and high K⁢, while the sensitivity remained unaltered. Endothelium-dependent relaxation, but not SNP-mediated relaxation, was reduced in STZ-treated rats. Plasma nitrite/nitrates are significantly increased in STZ-treated rats compared to controls. The malondialdehyde (MDA) contents of liver, serum, and aorta of...
589.

Role of Adenosine in the Activation of Myocardial Catalase Induced by Brief Regional Ischemia

Young-hoonKim, Chan-hyungKim, Gi-taeKim, HongChoi, Jong-wanPark, Myung-sukKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 7 53-57 (5 pages)

Young-hoonKim, Chan-hyungKim, Gi-taeKim, HongChoi, Jong-wanPark, Myung-sukKim 저
...
- 1,500원
The activities of myocardial antioxidant enzymes are known to increase in the hearts preconditioned with the brief episodes of ischemia. This study was undertaken to elucidate the possible involvement of adenosine in the stimulation of myocardial catalase induced by the brief regional ischemia in rabbit hearts. Coronary artery descending the middle anterior wall of left ventricle was occluded for 15 min, followed by 1 hr of reperfusion. Upon reperfusion after the brief ischemia, the activity of...
590.

정신분열병의 인지치료

정영철 대한신경정신의학회 신경정신의학 10 Pages

대한신경정신의학회 신경정신의학 1998, 제 37권 제 2호 2 215-224 (10 pages)

정영철 저
...
- 3,000원
지금까지의 정신증상 특히 망상과 환청에 대한 정신치료적 입장은 긍정도 부정도 아닌 중립적 태도로 충 분히 환자의 이야기를 들어주는 지지적 형태의 소극적 치료였다고 볼 수 있다. 그러나 인지치료는 직면이 아 닌 범위내에서 논리적이고 경험적 방법을 이용하여 적극적으로 증상의 공략을 추천하는 치료법인 것이다. 이 와같은 점에서 인지치료는 정신증상을 직접적으로 다루는 새로운 치료도구라는 의미가 있다. 또한 그 이론과 치료기법이 명료하고 손쉬워서 누구나 조금만 관심을 가지면 시행할 수 있는 강점도 가지고 있다....

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