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Effects of Dexamethasone and DHEA on the Changes of Glutamate and Polyamine Uptake in Rat Astrocytes by Lipopolysaccharide and Antimycin A
Sang-HyunChoi, BumLee, Kyung-HoShin, Bon-HongMin, Yeon-SookChun, Boe-GwunChun 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 3 137-146 (10 pages)
Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of dexamethasone and DHEA on the regulatory role of astrocytes in conditions of increased extracellular concentrations of glutamate or polyamines. 1. [3H]Glutamate uptake: LPS and antimycin A decreased Vmax, but both drugs had little effect on... -
Depression of Ca2+ Influx in Complement C5a-stimulated Neutrophils by Calmodulin Inhibitors
DongSukHam, HyunHoKim, EunSookHan, ChungSooLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 14 109-117 (9 pages)
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Discrepancy between in vitro and in vivo Effect of Gαs Gene Mutation on the mRNA Expression of TRH Receptor
SeungjoonPark, InmyungYang, SungvinYim, JoohoChung, JeechangJung, KyechangKo, YoungseolKim, YoungkilChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1998, Vol.2 No.1 13 101-108 (8 pages)
strong and prolonged contraction in trachealis musc1e strip. Strong tonic contraction by P AF was attenuated -
Study on Ginseng Protopanaxadiol and Protopanaxatriol Saponins- Induced Antinociception
Young-HeeShin, Seok-ChangKim, Ji-WonHan, Dae-HoonKim, Sang-SubHan, Dong-HoShin, Seung-YeolNah 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 4 143-149 (7 pages)
We studied the effects of ginseng protopanaxadiol (PD) and protopanaxatriol (PT) saponins on the analgesia using several pain tests such as writhing, formalin, and tail-flick test. Using mouse, pretreatment of PD or PT saponins (i.p.) induced inhibition of abdominal constrictions caused by 0.9% acetic acid administration(i.p.). The AD50 was around 27 (17-43) mg/kg for PD and 13.5 (3-61) mg/kg for PT saponins in writhing test. Both PD and PT saponins also showed the inhibition of bitings and... -
Lithium-induced Increase of Synaptosomal Uptake of Norepinephrine in Rat Brain
Young-WukCho, Seung-HoHan, Chang-JuKim, Byung-IlMin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.2 2 127-133 (7 pages)
Lithium remains the most widely used therapeutic agent for bipolar affective disorder, particularly mania. Although many investigators have studied the effects of lithium on abnormalities in monoamine neurotransmitter as a pathophysiological basis of affective disorder, the action mechanism of lithium ion remains still unknown. To explore the action mechanism of lithium in the brain, we examined the effects of lithium on the extrasynaptosomal concentrations of catecholamines and their... -
Effect of Cisplatin on Sodium-Dependent Hexose Transport in LLC-PK1 Renal Epithelial Cells
SukKyuLee, JeeYeunKim, TaiHyunYu, KyoungRyongKim, KwangHyukKim, YangSaengPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1997, Vol.1 No.1 5 35-43 (9 pages)
200 ㄍM. In cisplatin-treated cells, the Na+-dependent AMG uptake was drastically inhibited with no change in the Na+-independent uptake. Kinetic analysis indicated that Vmax was suppressed, but Km was not altered. The Na+-dependent phlorizin binding was also decreased in cisplatin-treated cells. However, the AMG efflux from preloaded cells was not apparently retarded by cisplatin treatment. These data indicate that the cisplatin treatment impairs Na+-hexose cotransporters in LLC-PK1 cells... -
정신병에서 Risperidone 사용으로 인해 유발된 조증
정동선, 한상우, 한선호 대한신경정신의학회 신경정신의학 6 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 2호 20 394-399 (6 pages)
Risperidone은 강력한 도파민(D2)과 세로토닌(5-HT2) 수용체 길항작용을 지니는 새로운 계열의 비전형 항정신병 약물중 하나이다. 최근 몇 년간에 걸쳐 분열정동형장애나 정신분열병을 치료하는 과정에서 risperidone으로 인해 유발된 조 증증상에 관한 여러 보고가 있어왔다. 우리는 2명의 정신분열병 환자와 1명의 amphetamine 정신병 환자에 서 risperidone으로 인해 유발된 조증 3례를 보고하고자 한다. 이런 현상은 risperidone이 다른 항정신병 약물과는 구별되는 강력한 후 시냅스 5-HT2 수용체 길항 작 용 때문인 것으로... -
우울증상을 수반한 폐경후 여성에서 항우울제와 Estraderm TTS의 병합치료 효과에 대한 연구
송현철, 조숙행 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 1995, 제 34권 제 3호 8 690-699 (10 pages)
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생쥐의 강제수영시 부동자세시간과 통각예민도 간의 상관관계
김길중, 박제민, 김명정 대한신경정신의학회 신경정신의학 8 Pages
대한신경정신의학회 신경정신의학 1991, 제 30권 제 4호 6 686-693 (8 pages)
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향정신성 약물의 Phospholipase C와 Protein Kinase C 효소활성에 미치는 영향 - 항정신병 약물을 중심으로 一
최 영, 이기영, 이형영 대한신경정신의학회 신경정신의학 9 Pages
대한신경정신의학회 신경정신의학 1992, 제 31권 제 5호 2 837-845 (9 pages)


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