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781.

Mechanism of Pituitary Adenylate Cyclase-Activating Polypeptide- Induced Inhibition on Catecholamine Secretion Evoked by Cholinergic Stimulation and Membrane Depolarization in the Rat Adrenal Gland

Dong-YoonLim, Jeong-WonKang, Young-JoKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 12 339-350 (12 pages)

Dong-YoonLim, Jeong-WonKang, Young-JoKim 저
...
- 4,100원
The present study was attempted to examine the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on catecholamine (CA) secretion evoked by cholinergic stimulation, membrane depolarization and calcium mobilization from the isolated perfused rat adrenal gland. The perfusion of PACAP (10 nM) into an adrenal vein for 60 min produced a great inhibition in CA secretion evoked by ACh (5.32⁓10⁣3 M), high K⁢ (5.6⁓10⁣2 M), DMPP (10⁣4 M for 2 min),...
782.

Thyroid Hormone-Induced Alterations of Ryanodine and Dihydropyridine Receptor Protein Expression in Rat Heart

HaeWonKim, MiyoungPark, EunHeeLee, HyoungJinCho, HeeRanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.3 11 329-337 (9 pages)

HaeWonKim, MiyoungPark, EunHeeLee, HyoungJinCho, HeeRanLee 저
...
- 3,000원
Thyroid hormone-induced cellular dysfunctions may be associated with changes in the intracellular Ca2⁢ concentration. The ryanodine receptor, a Ca2⁢ release channel of the SR, is responsible for the rapid release of Ca2⁢ that activates cardiac muscle contraction. In the excitation-contaction coupling cascade, activation of ryanodine receptors is initiated by the activity of sarcolemmal Ca2⁢ channels, the dihydropyridine receptors. In hyperthyroidism left ventricular...
783.

Thyroid Hormone-Induced Alterations of Ca2+-ATPase and Phospholamban Protein Expression in Cardiac Sarcoplasmic Reticulum

HaeWonKim, KyungMinNoh, MiyoungPark, HeeRanLee, EunHeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 13 223-230 (8 pages)

HaeWonKim, KyungMinNoh, MiyoungPark, HeeRanLee, EunHeeLee 저
...
- 3,000원
Alterations of cardiovascular function associated with various thyroid states have been studied. In hyperthyroidism left ventricular contractility and relaxation velocity were increased, whereas these parameters were decreased in hypothyroidism. The mechanisms for these changes have been suggested to include alterations in the expression and/or activity levels of various proteins; α-myosin heavy chain, β- myosin heavy chain, β-receptors, the guanine nucleotide-binding regulatory protein, and...
784.

Effects of Ethanol on Na+-dependent Solute Uptake in Rabbit Renal Brush-Border Membrane Vesicles

YongKeunKim, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 9 191-198 (8 pages)

YongKeunKim, SunHeeKo, JaeSukWoo, JinSupJung, SangHoLee 저
...
- 3,000원
This study was undertaken to examine the effect of ethanol on Na⁢-dependent transport systems (glucose, phosphate, and dicarboxylate) in renal brush-border membrane vesicles (BBMV). Ethanol inhibited Na⁢- dependent uptakes of glucose, phosphate, and succinate in a dose-dependent manner, but not the uptakes of Na⁢-independent. The H⁢/TEA antiport was reduced by 8% ethanol. Kinetic analysis showed that ethanol caused a decrease in Vmax of three transport systems, leaving...
785.

Minimal Amount of Insulin Can Reverse Diabetic Heart Function Sarcoplasmic Reticulum Ca2+ Transport and Phospholamban Protein Expression

HaeWonKim, YongSunCho, YunSongLee, EunHeeLee, HeeRanLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 7 175-182 (8 pages)

HaeWonKim, YongSunCho, YunSongLee, EunHeeLee, HeeRanLee 저
...
- 3,000원
In the present study, the underlying mechanisms for diabetic functional derangement and insulin effect on diabetic cardiomyopathy were investigated with respect to sarcoplasmic reticulum (SR) Ca2⁢-ATPase and phospholamban at the transcriptional and translational levels. The maximal Ca2⁢ uptake and the affinity of Ca2⁢-ATPase for Ca2⁢ were decreased in streptozotocin-induced diabetic rat cardiac SR, however, even minimal amount of insulin could reverse both parameters....
786.

Molecular Analysis of AQP2 Promoter. I. cAMP-dependent Regulation of Mouse AQP2 Gene

MiYoungPark, YongHwanLee, HaeRahnBae, RyangHwaLee, SangHoLee, JinSupJung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 5 157-164 (8 pages)

MiYoungPark, YongHwanLee, HaeRahnBae, RyangHwaLee, SangHoLee, JinSupJung 저
...
- 3,000원
To determine molecular mechanisms of Aquaporin-CD (AQP2) gene regulation, the promoter region of the AQP2 gene was examined by transiently transfecting a promoter-luciferase reporter fusion gene into mouse renal collecting duct cell lines such as mIMCD-3, mIMCD-K2, and M-1 cells, and NIH3T3 mouse embryo fibroblast cells. PCR-Southern analysis reveals that mIMCD-3 and mIMCD-K2 cells express AQP2, but M-1 and NIH3T3 cells do not, and that the treatment with cpt-cAMP (400μM) or forskolin/...
787.

Properties of Spontaneous Activity in Gastric Smooth Muscle

H.Suzuki, Y.Yamamoto, G.D.S.Hirst 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.2 1 119-125 (7 pages)

H.Suzuki, Y.Yamamoto, G.D.S.Hirst 저
...
- 3,000원
Mammalian gastric smooth muscles generate spontaneous rhythmic contractions which are associated with slow oscillatory potentials (slow waves) and spike potentials. Spike potentials are blocked by organic Ca2⁢-antagonists, indicating that these result from the activation of L-type Ca2⁢-channel. However, the cellular mechanisms underlying the generation of slow wave remain unclear. Slow waves are insensitive to Ca2⁢-antagonists but are blocked by metabolic inhibitors or low...
788.

Role of Phospholipase A2 in Hypoxia-Induced Renal Cell Injury

WonRakChoi, SunHeeKo, SuInCho, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 12 93-100 (8 pages)

WonRakChoi, SunHeeKo, SuInCho, JaeSukWoo, JinSupJung, SangHoLee, YongKeunKim 저
...
- 3,000원
The present study was designed to assess the roles of PLA2 activation and arachidonic acid (AA) metabolites in hypoxia-induced renal cell injury. Hypoxia increased LDH release in a dose-dependent manner in rabbit renal cortical slices, and this increase was significant after 20-min hypoxia. The hypoxia-induced LDH release was prevented by amino acids, glycine and alanine, and extracellular acidosis (pH 6.0). Buffering intracellular Ca2⁢ by a chelator, but not omission of Ca2⁢ in the...
789.

Activation of SAPK and Increase in Bak Levels during Ceramide and Indomethacin-Induced Apoptosis in HT29 Cells

JuHoKim, SaeOckOh, SungSookJun, JinSupJung, JaeSukWoo, YongKeunKim, SangHoLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 10 75-82 (8 pages)

JuHoKim, SaeOckOh, SungSookJun, JinSupJung, JaeSukWoo, YongKeunKim, SangHoLee 저
...
- 3,000원
It has been reported that activation of sphingomyelin pathway and nonsteroidal anti-inflammatory drugs (NSAIDS) inhibit the promotion of colon carcinoma. Ceramide, a metabolite of sphingomyelin, and indomethacin were shown to induce apoptosis in colon carcinoma cells. However, the mechanisms of ceramide- and indomethacin-induced apoptosis in the colon carcinoma cells are not clearly elucidated. Recent studys showed that indomethacin-induced apoptosis in colon cancer cells through the...
790.

Cholinergic Activity Related to Cardiovascular Regulation in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

Seok-YongLeeSang-BokLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages

대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 1999, Vol.3 No.1 4 29-34 (6 pages)

Seok-YongLeeSang-BokLee 저
...
- 3,000원
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to clarify the mechanisms of cholinergic hyperactivity in RVLM of the SHR, we studied the activities of enzymes that participate in the biosynthesis and degradation of acetylcholine (ACh) and the density of muscarinic receptors in RVLM of the 14- to...

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