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본문검색 결과만 보기
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Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances the anti-cancer effect of cisplatin therapy
HyunseongKim, GihyunLee, Sung-HwaSohn, ChanjuLee, JungWonKwak, HyunsuBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.3 5 261-268 (8 pages)
Foxp3+ CD25+CD4+ regulatory T (Treg) cells are crucial for the maintenance of immunological self-tolerance and are abundant in tumors. Most of these cells are chemo-attracted to tumor tissues and suppress anti-tumor responses inside the tumor. Currently, several cancer immunotherapies targeting Treg cells are being clinically tested. Cisplatin is one of the most potent chemotherapy drugs widely used for cancer treatment. While cisplatin is a powerful drug for the treatment of multiple cancers,... -
Gecko Proteins Exert Anti-Tumor Effect against Cervical Cancer Cells Via PI3-Kinase/Akt Pathway
Ae-JinJeong, Chung-NamChung, Hye-JinKim, KilSooBae, SongChoi, WooJinJun, SangInShim, Tae-HongKang, Sun-HeeLeem, JinWoongChung 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 12 361-365 (5 pages)
exerted anti-tumor activities on HeLa cells, suggesting the involvement of PI3-kinase/Akt pathway in GP-induced cell death of the cancer cells. Indeed, the cytotoxic effect of GP against HeLa cells was inhibited by overexpression of constituvely active form of Akt in HeLa cells. The candidates of the functional proteins in GP were analyzed by Mass-spectrum. Taken together, our results suggest that GP elicits anti-tumor activity against HeLa cells by inhibition of PI3-kinase/Akt pathway. -
Anti-ischemic Effect of Polygala Tenuifolia in Isolated Rat Heart
Chang-WonKang, Jong-HoonKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 7 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 3 89-95 (7 pages)
group was significantly recovered 60 min after reperfusion compared to the control group (systolic aortic pressure: 83.3% vs. 64.9%, aortic flow volume: 69.5% vs. 48.7%, coronary flow volume: 77.7% vs. 58.4%, and cardiac output: 71.6% vs. 51.2%, p＜0.01). As for the underlying mechanism, PT significantly prevented intracellular calcium increase which was induced by isoproterenol (p＜0.01), suggesting that the anti-ischemic effect of PT is mediated by inhibition of intracellular calcium increase. -
The Effect of Samul-tanggahyangbuja on Anti-Depressive Behavior and Immunity
장윤정, 김송백, 최창민, 서윤정, 조한백, Jang. Yoon-Jeong, Kim. Song-Baek, Choi. Chang-Min, Seo. Yun-Jung, Cho. Han-Baek 대한한방부인과학회 大韓漢方婦人科學會誌 16 Pages
대한한방부인과학회 大韓漢方婦人科學會誌 2013, Vol.26 No.4 14-29 (16 pages)
및 anti-inflammatory cytokine인 IL-4에 미치는 영향을 연구하고자 하였다. 방 법: 난소적출 흰쥐에 2주간 반복적인 스트레스를 주고 동시에 SGH(200 and 400 mg/kg/day)를 경구 투여한 후 행동검사인 Elevated Plus Maze(EPM)를 통한 우울행동과 혈청 estradiol, IL-4의 변화를 측정하였고, 또한 뇌 내 Locus coeruleus(LC)와 Paraventricular Nucleus(PVN)에서 IL-4의 변화를 측정하였다. 결 과: 1. EPM에서 SGH 400 mg 투여군은 대조군에 비해서 open arms에 머무는 시간이 현저히 증가하였고, closed arms에 머무는 시간이 현저히... -
Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model
Seo. Jong-Bae, Jeong. Jae-Yeon, Park. Jae-Young, Jun. Eun-Mi, Lee. Sang-Ik, Choe. Sung-Sik, Park. Do-Yang, Choi. Eun-Wook, Seen. Dong-Se 한국응용약물학회 Biomolecules & therapeutics 9 Pages
한국응용약물학회 Biomolecules & therapeutics 2012, Vol.20 No.1 104-112 (9 pages)
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Anti-inflammatory effects of low-level laser in burn wound models in rats
Eun-Jeong Kim, Se-Hun Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 4호 3 170-175 (6 pages)
Objective: The anti-inflammatory effects of low-level laser in burn wound model in rats were investigated. Design: Randomized controlled trial. Methods: The rats were assigned to three experimental groups. Group I received second-degree burn wounds; Group II received dressing film and low-level laser (1.2 J/cm2) treatment after a burn wound; Group III received dressing film and low-level laser (2.3 J/cm2) treatment after a burn wound. After inducing a deep second-degree burn wound, the wound was... -
Lycopene Inhibits Nicotine-induced Embryo Anomalies Via Antioxidative, Anti-apoptotic, and Anti-inflammatory Activities
Seul Gi Park, Chunmei Lin, Sl Bi Chu, Jung Min Yon, Lee Wha Gwon, Beom Jun Lee, Young Won Yun, Sang Yoon Nam 대한수의학회 대한수의학회 학술대회발표집 1 Pages
대한수의학회 대한수의학회 학술대회발표집 춘계학술심포지움 117 199-199 (1 pages)
