The author has studied the histochemical changes on rat submaxillary gland histological changes on rat periodontium after administration of isoproterenol. The results are as follows: 1) After administration of isoproterenol, the rat submaxillary glands weight of the first and second group were increased two times compared with control group. 2) The acinar cells of rat submaxillary gland were shown the hypertrophy and enlargement. 3) The PAS staining reaction of the acinar cells of rat submaxillary gland were shown the strong positive reaction. 4) The blood vessels of rat periodontium were dilated and alveolar bone resorption was occurred.