Fourteen patients with typhoid fever were studied by scanning and clearance-rate measurements of subcritical dose colloidal radiogold($^{198}Au$). Mild to moderate enlargement of the liver and spleen was noted in 78.6 and 64.3 per cent of patients, respectively; and splenic and spinal bone-marrow uptake was seen in 78.6 and 57.1 per cent of cases, respectively. Typically, these scan changes occurred concomitantly (57.1%) and are considered to represent increased phagocytic activity of the RE cells which is characteristic of typhoid fever. The half clearance-time was significantly shortened during the first 10-day period of the illness indicating an increas in the hepatic blood in the early phase of typhoid infection. Hepatomegaly, splenomegaly and extrahepatic uptakes along with an accelerated (or later a normal) clearance time are characteristic of typhoid fever.