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시판의약품(市販醫藥品)의 미생물(微生物) 오염도(汚染度) 조사(調査) (제2보)(第2報) - 시판내복액제(市販內服液劑)의 세균오염도(細菌汚染度) -
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  • 시판의약품(市販醫藥品)의 미생물(微生物) 오염도(汚染度) 조사(調査) (제2보)(第2報) - 시판내복액제(市販內服液劑)의 세균오염도(細菌汚染度) -
저자명
박영주,김영일,Park. Young-Ju,Kim. Young-Il
간행물명
藥劑學會誌
권/호정보
1973년|3권 4호|pp.16-27 (12 pages)
발행정보
한국약제학회
파일정보
정기간행물|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

An investigation was carried out on a basis of the examination with a view to detecting the degree of microbial contamination for the 82 samples collected from the locally-sold liquid preparations. The results obtained are summarized as follows ; 1. Total viable Bacteria(TVB) per ml. in test sample shows min. 0 and Max. $8.0{ imes}10^5$. Among the test samples, 2 items of Herb medicines have shown the highest bacterial contamination degree. 2. The number of unsuitable products are 9(11.0%) of the 82 items tested. Comparing with the study of 1971 (18 or 23.4% of 77 items), this fact suggests that the more than 50% decreasing tendency has come from the technical preventive efforts on bacterial contamination. 3. E. coli, Staph. aureus, and Pseudomonas aeruginosa could not be detected with the test sample. 4. The number of confirmable mycotic contamination in the test samples has been revealed as 17 items (20.7%). 5. Chiefly, the causative organisms of the contamination are proved to be bacilli and fungi broadly distributed in nature. 6. Generally, the neutrality of the pH had greatly increased the number of products unsuitable on the specification of TVB. pH >7.0 No. of unsuitable items 0/4 (0.0%) pH 6.0-7.0 No. of unsuitable items 4/9 (44.4%) pH 4.0-6.0 No. of unsuitable items 5/45(11.1%) pH <4.0 No. of unsuitable items 0/24(0.0%) 7. The viability of general bacteria has shown a rather decreasing tendency in time.