Conventional esophagography with fluoroscopy is not so accurate in diagnosis of esophageal varices, and correct diagnosis can established only 15∼50% of cases. Although various approaches have been used to increase diagnositc accuracy, none of them has proved entirely satisfactory. This report represents our experience with the use of Pro-banthine, which has spasmolytic action on smooth muscle, in 20 patients in whom esophageal varices are stongly suggested clinically, but conventional esophagogram reveals no evidence of varices or only mild findings of varices. Repeated esophagogram after intramuscular injection of 30mg of Pro-banthine revealed findings of esophageal varices in 4 of the 10 patients whose conventional esophagogram revealed normal finding, and revealed more prominent findings of varices in other 1- patients whose conventional esophagogram revealed mild or suspicious findings of varices. We recommand Pro-banthine enhanced esophagogram to increase diagnostic acc racy when esophageal varices are suspected clinically.