ORAL CHOLECYSTOGRAPHY is one of the most widely used diagnostic procedure. Yet in a considerable number of the patients, the gallbladder may not be visualized or is only very faintly opacified with contrast medium. the schedule of the administration of the contrast medium typically starts from 9 PM after elimination of fat meal from the meals prior to the administration. This time-honered schedule of administration has been in use without appropriate understanding of the mechanisms of the intestinal absorption, conjugation in the liver and excretion into the biliary system of contrast material. It is, however, now very clear that the contrast medium must first be absorbed from the intestinal tract. The present study has been carried out to test the effect of fractionated administration of Telepaque on visualization of the gallbladder and on the incidence of the finding of conjugated contrast materials within the colon. Two hundred unselected consecutive patients were subjected to oral cholecystography employing conventional and fractionated administration of Telepaque, respectively. The new method consisted of aking one tablet of Telepaque every hour starting at 3 PM the day before the examination, instead of taking the tablet every 5 min. starting at 9 PM. Radiographs taken in the next morning were evaluated according to the grading method employed by Koehler and Kyaw. It is graded from 0 to 4＋, 0 being non-visualization and 4＋ being excellent visualization (Table 3). The present study revealed that there was a significant increase in the number of the radiographs with good diagnostic quality when the fractionated method was used. It is also clear that more patients showed conjugated contrast medium when the fractionated method is used. This enhanced conjugation of contrast medium is utilized to increase the visibility of biliary tree by tomography when the gallbladder is not opacified.