A Radiological analysis was made of 13 cases of confirmed acromegaly and gigantism. And observation was made in skeleton and soft tissue of patients at Yonsei University from 1968 to 1973. The results was following as; 1. Main clinical symptoms were headache (8/13) and visual disturbances (5/13) in acromegaly and gigantism. 2. Characteristic radiologic findings were analyzed in 13 cases. a. Plain skull show marked thickenning of skull vault, prominent frontal bossing, thickenning of external occipital protuberance, basal kyphosis increment and decreased facial angle. b. Facial bone show lower positioning of the symphysis of mandible and hyoid bone, curved hard palate, protrusion of tongue and flaring of the teeth. c. Acromegalic measurement of vertebra show increased height of body, interpedicular distance and marginal degenrative changes of vertebra. d. Increased size of hand length, P-M joint spaces of hand, increased tuft width and sesamoid index were shown. e. Marked thick nning of heal pad are also demonstrated. e. Marked thickenning of heel pad are also demonstrated. Details of analysis disclosed overlapping of signs of each indivisualized skeleton and soft tissue.