The NMR spectra of 2,4-disubstituted or 2,4,6-trisubstituted anisole derivative were examined to study the chemical shift of the ring proton signal. It was found that the chemical shift of the ring proton nearest to the 2-substituted group was influenced by the deshielding effect of the neighboring substituted groups in order of the Van der Waals radii of those groups. These observations were interpreted as a steric influence of 2-substituted group on the reactivity of the neighboring ring proton itself. The spectroscopical data were presented and the results were discussed with views of the above conceptions.