Author had experienced orthodontic cases that had been treated by the extraction of premolar at department of orthodontics, Tokyo Dental College. This report contains four cases which occlusion and profile were well improved by the orthodotic treatment. Four cases were all female. Two cases started orthodontic treatment at the age of puberty the other at adult. All the cases needed maximum anchorage. As a result, treatment were succeeded and profile was well advanced by growth and anchorage. In orthodontic treatment, the growth and anchorage are the KEY which lead to success. But the prediction of growth is very difficult.