Bone scanning has changed the management of patients and has increased the understanding of number of diseases affecting the skeleton. Early diagnosis of benign and malignant bone disease has become possible many months before a standard x-ray or enzyme measurement confirms the pathologic process. Whole-body bone scanning is a non-invasive, safe, and easy procedure. 99mTc is the good for skeletal image. The relative cost of this is low, its availability is widespread, and it is obtainable in generator form, with a good shelf-life, thus being available whenever required. It also has an absence of a particle emission, decaying by a single gamma ray of reasonable energy (140 KeV) with a good physical half-life (6 hours). We have 36 cases of whole-body scanning with 99mTc-EHDP. the result are as follows: 1. In 36 cases, positive bone scanning and negative X-rays were found in 22.2% of the patients, and in positive x-rays bone scanning showed almost positive. 2. In 4 cases, bone sc nning showed increased uptake of radioactivity in primary bone tumor. 3. Also bone scanning showed increased uptake of radioactivity in amputative or operative site. 4. In 1 case of osteomyelitis, x-rays showed negative findings, but bone scanning showed increased uptake of radioactivity in site to suspect clinically. So bone scanning is very sensitive indicator of bone infections-the early detection of osteomyelitis and septic arthritis is fundamental in order to prevent demarge to the bones and joints.