This experiment is to search what some chemicals polluting water have an effect on the Rana nigromaculata Hallowell, in the survival rate and the metamorphosis speed from a tadpole to a young frog. 1. The fatal thickness by some agricultural chemicals and copper sulfate is different from one another. The fatal rate in the contrast group is 15 percent, and particulary Dithane M-45 is the most among the all reagents. 2. The effect on the anamorphosis is very severe. In the case of contrast group, it appears to stage 25, but it is not to appear at the group used agricultural chemicals. 3. The less the thickness of that is, the less the influence of the survival rate and the metamorphosis speed. 4. The density of the agricultural chemical is in inverse proportion to the survival rate and the metamorphosis speed, and the other side, the fatal rate is proportion.