Cryptococcosis is uncommon mycotic disease caused by Cryptococcus neoformans, with a special affinity for the respiratory and central nervous system. and less frequently affecting liver, spleen, skin lymph nodes and kidney. It was first described by Busse in 1894, and since then the occurrences had been world-widely reported with increasing incidence. The outcome of the disease may be fatal when the treatment is delayed. The main portal of entry is via the respiratory tract, and the pulmonary mainfestations are not specific but quite varying, that solitary or multiple pulmonary masses, nodular or reticular infiltrations, cavity formation, lymphadenopathy o rpleural effusion can be detected on the chest X-ray film simulating many other disease. Authors analyzed and evaluated 16 cases of confirmed cryptococcosis, and interesting clinical and radioligic features that definitely differed from mo t of the other reports were notable as follows : 1. The incidence of cryptococcosis ranks 3rd (4.3%) among deep mycoses, next to moniliasis and aspergillosis. 2. 15 of 16 patients are in the period of pediatric age under 16 years old of age. 3. There are no remarkable underlying diseases or predisposing factors encounteren in all of the 16 cases. 4.Besides the predominating meningeal irritating symptoms, the involvement of the reticuloendothelial system, i.e., lymph nodes, liver and spleen are notable. 5. Characteristic features of the pulmonary crytptococcosis are : a) 8 of 10 cases have marked hilar and paratracheal lymph nodes enlargement. b) None of the cases revealed solitary pulmonary mass, cavity formation or pleural effusion. c) The lung infiltrations are mainly reticular or coarse nodular pattern. d) The infiltrations are diffusely distributed on entire lung field, rather than the predilection for the lower lobe. 6. Similarly to most of the other reports, the central nervous system involvement are most frequent (12 of 16 cases). 7. The combined therapy with Amphotericin B and 5-FC was done in all patients and resulted good improvement in 13 of 16 cases.