- 피임제(避妊劑) 제형(製型) 개발(開發)에 관(關)한 연구(硏究)(I)
- ㆍ 저자명
- 김성호,최준식,백채선,Kim. S.H.,Choi. J.S.,Baik. C.S.
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1981년|11권 3호|pp.14-20 (7 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
One of the major objectives in the developments of a progesterone I.U.D. is to prepare devices which release drug at a constant rate for extended periods. A constant release rate is achived by maintaining drug concentration at a constant valve via the introduction of rate limiting membrane to solute diffusion at the surface of the devices. In this study, progesterone dispersed at monolithic device were prepared from polyhydroxy ethyl methacrylate. Constant release rate were obtained with device which were soaked in on ethanol-hexan solution. The release rate was dependant upon the concentration of the ethanolic solution in the soaking solution. This devices offer significant potential for futher development of hydrogel in the intrauterine contraception device for controlled release of progesterone.