This study was conducted to examine the best population density and agronomic characteristics affected by different row-widths and planting-spaces within row in safflower. As both row-width and spacing were narrowed, plant height and height to first branch were increased, and the number of branch per plant showed decrease. Plant height showed negative correlation with row-width, height to first branch showed negative correlation with row-width x spacing, and number of branch per plant had positive correlation with row width, and row-width x spacing but negative correlation with plant height. Yield was affected by spacing and row-width x spacing. In spacing, 5cm plot performed the best yield, and 30 x 5cm population density was the best cultural method to increase safflower yield. Yield had negative correlation with spacing and row-width x spacing, but positive correlation with height to first branch.