The vaso-epididymography and vasoseminal vesiculography is the only diagnostic method for investigating the patency and abnormal lesion of male genital system radiologically. The author performed 53 cases of vaso-epididymography and vasoseminal vesiculography in Busan National University Hospital during the 8 years from 1973 to 1981. All patients complained of primary infertility more than a year and were confirmed azoospermia on semen examination, and 23 cases of them underwent testicular biopsy. The results are as follows: 1. The age distribution were mainly between 26 and 35 years old (83.0%). 2. The infertile duration were almost from 1 to 5 years (86.8%). 3. The past history associated with infertility was gonorrhea, tuberculosis and scrotal trauma. 4. Of the 23 cases confirmed by testicular biopsy, the pathologic findings were normal spermatogenesis in 12 cases (52.2%) and hypospermatogenesis or arrest type in 11 cases (47.8%). 5. Non-filling sites of contrast media on vaso-epididymography and vasoseminal vesiculography were epididymis (83.0%), ejaculatory duct (41.5%) and seminal vesicle (24.5%), were commonly bilateral (68.0%) and were more prevalent in the right side than left (1.2:1.0). 6. The abnormal findings of ejaculatory ducts, seminal vesicles, vas ampullas and vas deferens were mainly stricture or obstruction, obstruction or dilatation, beaded appearance or obstruction and obstruction respectively. 7. In the epididymis, there was almost obstructive lesion at the tail portion (83.0%).