A convenient high performance liquid chromatographic method for the quantitative determination and content uniformity of prednisolone in tablets is described. The prednisolone was chromatographed using a ${mu}-Bondapak;C_{18}$ column and the eluent 70% MeOH at a flow rate 1. 0ml/min. Diethylstilbestrol was used as an internal standard. The UV detector response at 254nm was linear over a range of $10{sim}60{mu}g/ml$ under conditions of the analysis. Reproducibility studies gave relative standard deviations of $0.3{sim}0.5%$.