It has been known that alterations in blood pressure, heart rate and other systemic reactions can occur after introduction of contrast media into the vascular system. And the factors of these alterations are the sudden changes of the circulation blood volume, hypertonicity of the injected contrast media and adverse reactions to the contrast media. This prospective study included evaluations of the hemodynamic changes, adverse reactions and its relationship with sensitivity test and allergic history in 105 patients who had been performed angiocar-diography during the period of 1 year from October, 1981 to September, 1982. The results were as follows : 1. 14 out of 105 patient showed minor reactions to contrast media such as nausea, vomiting, coughing, etc. There is no close relationship between adverse reaction and sensitivity test or previous allergic history. 2. In the group of right sided angiocardiography, 47.6% of patient showed elevation of blood pressure after injection of contrast media. 38.1% of patient, however, showed lowered blood pressure. The chages of the pulse rate were quite similar to those of blood pressure ; increased in 47.7% and decreased in 40.9% of patient. 3. In the group of left sided angiocardiography, 61.6% of patient showed elevation of blood pressure immediately after injection of contrast media, and 17.5% of patient showed lowered blood pressure, 5 minutes after injection of contrast media, large group of patient showed normalized blood pressure. The pulse rate was also increased in the 66.3% of patient.