Triose reductone으로 수식된 guanine 유도체의 $lambda$ 및 calf thymus DNA에 대한 절단작용을 agarose electrophoresis로 검토하였다. Tricylcic type인 $N^2$-(2-hydroxypropenylidene) guanin과 open type인 $N^2$-(3-oxo-2-hydroxypropenyl) guanine은 $CuSO_4$ 존재하에서 DNA 절단작용을 가지고 있으며 후자가 더 강한 활성을 가지고 있다. 또한, 그 guanine 유도체들의 DNA에 대한 절단작용은 triose reductone 보다 약한 활성을 나타냈다.
Double strands breakage of guanine analogs modified by triose reductone on $lambda$ and calf thymus DNA was investigated by using agarose slab gel electrophoresis, $N^2$-(2-hydroxypropenylidene) guanine and $N^2$-(3-oxo-2-hydroxypropenyl) guanine, possessed, the DNA breaking activity in the presence of $CuSO_4$, and the latter was more active than the tricyclic type analog. The DNA breakability of the analogs was weaker than that of triose reductone.
