The methanol extracts of five medicinal plant materials selected were tested for antihepatotoxic activity. Protective effects on the liver defect caused by $CCl_4$ can be proved by liver enzyme activities of serum GOT, GPT, LDH and ALP. The curative effects of these materials against $CCl_4-induced$ liver damage in albino rats were compared with those of control groups. It was shown that the extracts of Hepatica asiatica and Stellaria media showed antihepatotoxic effect on $CCl_4-induced$ liver damage; however, the extract of Gleditschia officinalis had no effect.