For the purpose of improving the fluidity of enteric-coated powders, various mineral silicates were added during spray drying process. Aqueous slurries of cimetidine, mineral silicates containing CMEC (carboxy methyl ethyl cellulose) were spray dried using a centrifugal wheel atomizer. The finely agglomerated powders obtained by this process were flowing as opposed to the original powders. The effect of four mineral silicates (colloidal silica, talc, bentonite, and kaolin) on the micromeritic properties and dissolution profiles of spray dried agglomerates were examined.