This study was undertaker to observe the longitudinal change by orthodontic treatment for early Class III malocclusion in primary and mixed dentition. Cephalometric roentgenograms of 8 children with Class III malocclusion obtained during activator therapy were measured and compared with those obtained before activator therapy. The following results were observed. During treatment with activator; 1. The maxilla became retrueded in A,C,E, and K and protruded in F, G, H, and J. 2. The mandible became retruded in A,C,E, and F and F and protruded in H and J. No difference was observed in G and K. 3. Gonial angle became reduced in A,C,E,F, and K and increased in H. No difference was observed in G and J. 4. The steepness of mandibular plane became reduced in C,E,F,G,H, and J and increased in A. No difference was observed in K. 5. The inclination of upper incisor became more labially in A,C,E,G,H,J, and K. No difference was observed in F. 6. The inclination of lower incisor became more lingually in all cases.