Over a period of recent 12 months, 41 patients who had localized pumonary lesions, but were not diagnosed pathologically through bronchoscopy, transbronchial biospy, sputum examinationa and cervical lymph node biopsy, underwent percutaneous needle aspiration and biopsy with a diagnostic accuracy of 83% concerning malignancy vs. benignity and 78% considering the specific cell type as well. Six patients developed small asymptomatic pneumothorax and the other three developed small amount of hemoptysis : One of them required treatment. There were 21 malignancies and 14 benign lesions. Three cases were misinterpreted and five were inconclusive on cytology, maybe due to inadequate material. No material was aspirated in one case due to hardness of the mass, which, later, confirmed chondrosarcoma on surgery. The method, problems and complications are discussed. Nowadays, the percutaneous needle aspiration and biospy appears to be the procedure of choice in pulmonary coin lesions especially when they are smaller, more peripheral, and whenever metastatic neoplasm is suspected.