Authors recommend ultrasound be used as a screening test in evaluation of suspected liver masses. Besides its speedness, wid availability, easy scheduling and lack of radiation hazard, ultrasound is higher in sensitivity, better in characterization of a lesion, and better in staging of a cancer than radionuclide scanning. Ultrasound could be used to delineate pedunculated hepatoma and anatomic variations, to differentiate intrahepatic from extrahepatic lesions, and to evaluate multiple organs simultaneously, while radionuclide scanning can not afford any benefit in these aspects. In addition, ultrasound could be used as a guide for diagnostic or therapeutic aspiration.