The effects between preexisting four types and one that author had designed of posterior palatal seal on the retention of denture base were compared and observed from six systemically healthy edentulous subjects. Using one without posterior palatal seal as the control, the retention of each type was measured and analyzed six times with cantilever type Load cell after adaptation of denture base, which were constructed with usual manner. The following results wear obtained. 1. Morphological and positional changes of posterior palatal seal effected on denture retention. 2. No specific type showed most desirable effect in every experimental subject. 3. Experimental subject I, II, VI showed higher retention on the control in every type. 4. In five types of posterior palatal seal, for subject III, VI F types and for subject II, V C types were most effective. 5. In each experimental subject F type showed higher retention than the control.