X선의 생물체에 대한 효과는 뢴트겐이 X-선을 발견한 이래 산발적으로 보고되어 왔으나 원폭의 인류사용을 계기로 하여 급격히 진행되어 왔다. 여러 가지 동물을 사용하여 수많은 연구가 계속되어 왔으나 그 중에서도 혈액상에 관한 변화는 근래에까지도 계속되고 있다. 저자들은 잡종 백서를 사용하여 방사선에 가장 감수성이 예민한 부위인 전복부에 고식적인 분할조사를 실시하여 체중과 혈액상의 변화를 분석하였고 이 결과를 토대로 하여 화학요법등과의 병합 치료에서 혈액상의 변화를 비교할 수 있는 기본자료로 이용하고자 한다.
Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ray. Various experimental animals were tried for radiobiological studies. 72hybrid mice with conventional faction $(15 imes/week)$, large abdominal field $12 imes3cm$, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about $29.7\%$ in male; $30.4\%$ in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to $40-50\%$ of pretreatment values by only 1000rad irradiation. Change of differential count was interesting; : lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed + - +++, showing no correlation with dosage. Application of our study in clinical combination therapy (radiation + chemotherapy) was discussed.
