While the appearance of new textiles and processing materials results in the improvement in quality of clothes and its luxury, a question about the irritation of clothes on the human body must be raised. In Japan and many countries in Europe, they are searching for a countermeasure against the bad influence of clothes on the human body for the purpose of protecting consumers. In our country, a little bit of study about the skin irritatio has been carried out. In this thesis, the literature on the kinds of the irritation of clothes on the human body was studied and analysed. And then I arranged it from the view-point of clothing hygienics. For example, we should observe the legal regulations and the administrative control in the process of production and distributive management of clothes for our safety. Therefore the authorities concerned must have preparations for the safety and this monograph is going to give information for it.