Increased splenic uptake of radiocolloid is a helpful sign in the scintigraphic diagnosis of diffuse hepatocellular diseases, but any attempt has been made to quantify this physiologic phenomenon. The purpose of the study is to evaluate a simple computer quantitation of S/L ratio and determine normal range and S/L ratios for various hepatic diseases. Authors analized S/L ratios of 1984 cases of liver scintigraphy from July 1984 to May 1985. The results are as follows; 1. The age distribution of normal and various hepatic diseases was most frequent in 30 to 40 decade. 2. The classification of studied groups were normal subjects(80 cases), hepatitis(30 cases), liver cirrhosis(59 cases), hepatoma(8 cases), metastasis(10 cases), and miscellaneous diseases(7 cases). 3. The simple computer quantitation method exhibits small interobserver variation. (r=0.92, p<0.01) 4. The mean S/L ratio in normal group was determined 0.34 (S.D=0.12) with a its range from 0.10 to 0.58(0.34$pm$2 S.D). T e mean S/L ratios in various hepatic diseases were as follows; 0.52(S.D=0.18) in hepatitis, 1.10(S.D=0.43) in cirrhosis, 0.77(S.D=0.38) in hepatoma, 0.47(S.D=0.21) in metastasis, and 0.43(S.D=0.17) in miscellaneous diseases. 5. The elevated S/L ratios rather than noraml values were found in hepatitis(30%), cirrhosis(51%), hepatoma(63%), and metastasis(20%). 6. The sensitivity of single scintigraphic diagnosis of liver cirrhosis was 63%, but the sensitivity was improved to 90% when combined with S/L ratio. 7. The simple computer quantitation of the S/L raio is a valid and useful method in the interpretation of liver scintigraphy and also may increase the sensitivity in the diagnosis of liver cirrhosis and hepatoma combined with cirrhosis.