The ultrasound-guided fine needle aspirations were performed in order to diagnose a suspected neoplastic or infectious disease in 52 patients with focal liver disease. Of these, neoplastic lesions were suspected in 31 patients and infectious lesions in 21 patients ultrasonically and/or clinically. The overall accuracy for both suspected malignant and infectious disease was 79%(41/52). The primary indication for fine needle aspiration was to document the presense of malignancy and to aboid a diagnostic laparotomy, and to drain hepatic abscesses. Consequently we were convinced that the ultrasound-gruided percutaneous find needle aspiration biopsy in the focal liver disease is the best method for a conclusive diagnosis.